Corneal Infiltration and CMV Retinitis in a Patient with AIDS

Hayashi, Kozaburo; Omoto, Tatsuya; Kosaki, Ryo; Higaki, Shiro; Shimomura, Yoshikazu

doi:10.1097/00003226-199807000-00016

Cited by 13 publications

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“…Corneal involvement in such cases is not uncommon. A number of reports have documented the presence of corneal deposits in HIV patients with CMV retinitis [1][2][3] or in patients with systemic CMV infection. [3][4][5] The deposits in these cases have been variably-pigmented (ranging from white to yellow and brown), were located predominantly in the peripheral cornea, 4 and have been invariably confined to the level of Descemet's membrane 4 or corneal endothelium, 1 with the exception of peripheral stromal involvement in one case.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5] The deposits in these cases have been variably-pigmented (ranging from white to yellow and brown), were located predominantly in the peripheral cornea, 4 and have been invariably confined to the level of Descemet's membrane 4 or corneal endothelium, 1 with the exception of peripheral stromal involvement in one case. 2 Rare epithelial and stromal manifestations of CMV infection have been reported, 5,6 with patients presenting a range of symptoms and exhibiting corneal findings of stromal scarring, edema, and enlarged, infected epithelial cells and stromal keratocytes, with a progressive worsening of the condition.…”

Section: Introductionmentioning

confidence: 99%

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Transient Anterior Corneal Deposits in a Human Immunodeficiency Virus-Positive Patient

Peebo

Lagali

2010

Cornea

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Results:The patient had a history of mycobacterium avium infection and was suspected to have recovery uveitis from a cytomegalovirus infection. Small, rounded, light brown-coloured deposits were distributed across the anterior cornea from limbus to limbus, bilaterally. In-vivo confocal microscopy revealed the deposits to be confined to the basal epithelium and Bowman's layer, while the posterior stroma, Descemet's membrane, and the endothelium appeared normal. Systemic steroid treatment was administered and two weeks later, the deposits had vanished on slit lamp examination, while remnants were observed at the microscopic level. Conclusions:The deposits were unusual for their anterior corneal location and pan-corneal distribution. The response to systemic steroid treatment remains unexplained and illustrates 2 the complexity of the underlying conditions, their treatment, and the associated pathways of ocular manifestation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Transient Anterior Corneal Deposits in a Human Immunodeficiency Virus-Positive Patient

Peebo

Lagali

2010

Cornea

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“…To date, only 7 cases with CMV involvement of corneal stroma have been reported in the literature (Table 1). [4][5][6][7][8][9] Although CMV retinitis primarily affects immunocompromised individuals, CMV anterior uveitis and endotheliitis are typically seen in immunocompetent hosts for reasons that are not clearly understood. 1 However, 2 previous case reports of CMV stromal keratitis occurred in patients with an immunocompromised status.…”

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Stromal Keratitis Associated With CMV Anterior Uveitis

Pisitpayat,

Mentreddy,

Pekmezci

et al. 2024

Cornea

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Purpose: Human cytomegalovirus (CMV) has commonly been reported as a cause of anterior uveitis and corneal endotheliitis. Unlike its other herpetic family members, herpes simplex virus and varicella zoster virus, involvement of the corneal stroma in CMV is uncommon. In this case series, we describe patients with CMV stromal keratitis. Methods: This was a retrospective chart review of patients seen at a tertiary referral center from 1999 to 2023 with stromal keratitis who tested positive for CMV by directed polymerase chain reaction of aqueous fluid or corneal tissue. Results: This series describes 5 patients, 4 of whom presented with anterior uveitis and stromal keratitis and were confirmed to be positive for CMV through the polymerase chain reaction of aqueous fluid. The fifth patient experienced recurrent corneal graft failures, with the most recent failed graft being positive for CMV based on immunohistochemical stains of the corneal stroma. The average age of patients was 62 years (range 36–80 years). Only 1 patient (20%) exhibited elevated intraocular pressure with stellate keratic precipitates at the initial presentation, whereas 3 other patients (60%) had a known history of glaucoma. Conclusions: Uveitis specialists are well aware of CMV as a cause of recurrent, hypertensive anterior uveitis but should also consider CMV in cases featuring stromal keratitis. The corneal endothelium may serve as a reservoir for both anterior uveitis and development of corneal stromal inflammation as demonstrated by the immunohistopathology exhibited in 1 case.

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Medical Standards for Eye Banking

Glasser¹

2011

Cornea

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Corneal Infiltration and CMV Retinitis in a Patient with AIDS

Abstract: This is the first report of the corneal infiltration seen in an AIDS patient with CMV retinitis. Etiological significance of the finding is discussed.

Cited by 13 publications

References 0 publications

Transient Anterior Corneal Deposits in a Human Immunodeficiency Virus-Positive Patient

Transient Anterior Corneal Deposits in a Human Immunodeficiency Virus-Positive Patient

Stromal Keratitis Associated With CMV Anterior Uveitis

Medical Standards for Eye Banking

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