Corneal Infections by Rhodotorula

Francois, J; Rijsselaere, M

doi:10.1159/000308833

Cited by 5 publications

(4 citation statements)

References 3 publications

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“…Rosa et al (19) reviewed the charts of 125 patients with fungal keratitis in South Florida for a period of 10 years (1982)(1983)(1984)(1985)(1986)(1987)(1988)(1989)(1990)(1991)(1992) and observed that the Candida genus accounted for 12% (16 cases) of all infections. Regarding species, C. albicans corresponded to 25% (20) . Wakisaka et al, after analyzing the cultures of corneal ulcers in 263 patients, from (6) .…”

Section: Discussionmentioning

confidence: 99%

Antifungal susceptibility testing of yeast isolated from corneal infections

Mascaro¹,

Hofling-Lima²,

Gompertz³

et al. 2003

Arq. Bras. Oftalmol.

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Antifungal susceptibility testing of yeast isolated from corneal infections INTRODUTIONFungi are opportunistic agents which rarely infect healthy corneas of immunocompetent individuals. Systemic and local underlying diseases may render the corneal tissues susceptible to infections with these organisms (1) . Trauma, specially related to organic materials, topical use of steroids and antibiotics (2)(3) , contact lens wear, surgical procedures, contamination of eye solutions, inappropriate maintenance of contact lenses (4) , systemic infections as well as any disease associated with immunodeficiency are considered risk factors for fungal eye infections (5) . In Brazil, the incidence of fungal eye infections ranges from 3.8 to 10%, depending on the site of the infection, the diagnostic tools available for fungal infections in the medical center and the seasons related to the studied period (6)(7)(8)(9) . The occurrence of keratomycosis is of great importance, not only because of diagnostic problems but also due to the severity of clinical manifestations and poor outcome despite antifungal treatment. The severity and progression of the fungal infection usually depend on the existence of Purpose: To report the antifungal susceptibility profile of yeast isolates obtained from cases of keratitis. Methods: Susceptibility testing of 15 yeast strains isolated from corneal infections to amphotericin B, fluconazole, itraconazole and ketoconazole was performed using the NCCLS broth microdilution assay. Results: Most episodes of eye infections were caused by Candida albicans. The antifungal drugs tested showed the following minimal inhibitory concentration values against yeast isolates: 0.125-0.5 µg/ml for amphotericin B; 0.125->64.0 µg/ml for fluconazole; 0.015-1.0 µg/ml for itraconazole and 0.015-0.125 µg/ml for ketoconazole. Despite the fact that all Candida isolates were judged to be susceptible to azoles, one isolate showed a minimal inhibitory concentration value significantly higher than a 90% minimal inhibitory concentration of all tested isolates. Rhodotorula rubra was resistant to fluconazole and itraconazole. Conclusions: Despite the fact that most yeast isolates from corneal infections are usually susceptible to amphotericin B and azoles, they exhibit a wide range of minimal inhibitory concentration values for antifungal drugs. The identification of strains at species level and their susceptibility pattern to antifungal drugs should be considered before determining the concentration to be used in topical antifungal formulations in order to optimize therapeutic response in eye infections.ABSTRACT

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Section: Discussionmentioning

confidence: 99%

Antifungal susceptibility testing of yeast isolated from corneal infections

Mascaro¹,

Hofling-Lima²,

Gompertz³

et al. 2003

Arq. Bras. Oftalmol.

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“…Until date, keratitis (6 cases) is reportedly more frequent than endophthalmitis (3 cases). [2345678910] or dacryocystitis. [11] Immunosuppression and indwelling catheters have been the most common risk factor for systemic and ocular infections.…”

Section: Discussionmentioning

confidence: 99%

“…This species has been the most common organism identified in keratitis (3 cases) in previous reports. [234] Additionally, there is one report of isolation of Rhodotorula glutinis [5] and two reports where the specific organism was not identified. [78]…”

Section: Discussionmentioning

confidence: 99%

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Rhodotorula mucilaginosa Keratitis: A rare fungus from Eastern India

Saha

Sengupta

Chatterjee

et al. 2014

Indian J Ophthalmol

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Rhodotorula mucilaginosa rarely cause keratitis in immunocompromised individuals. A 30 year old male with history of minor trauma presented with cotton wool like stromal infiltration and hypopyon in left eye. Microbiological examination of corneal scraping showed fungal hyphae and yeast cells in direct smear. Molecular identification of the organism was performed which showed 100% homology with Rhodotorula mucilaginosa. Management of these cases is difficult often necessitating surgical procedures. However further reports are necessary to understand the disease and establish a treatment protocol.

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