Corneal Factors Associated with the Amount of Visual Field Damage in Eyes with Newly Diagnosed, Untreated, Open-angle Glaucoma

Bolívar, Gema; Sánchez-Barahona, Cristina; Ketabi, Samira; Kozobolis, Vassilios; Teus, Miguel A.

doi:10.1007/s40123-021-00375-w

Cited by 4 publications

(7 citation statements)

References 17 publications

(24 reference statements)

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“…IOP lowering medications, particularly the prostaglandin analogues, have been shown to influence corneal biomechanics significantly. 17 – 19 Our results were in agreement with the study from Bolivar et al, 40 which found that the initial Corvis ST biomechanical parameters (DA, AT1, AV1, AT2, AV2, HC time, HC PD, HC radius) had no significant correlation with MD in treatment naïve POAG eyes.…”

Section: Discussionsupporting

confidence: 90%

“…Several previous studies reported the lack of association between IOP and MD in untreated POAG patients as well. 40 , 45 Also, there was a study that observed that age was not correlated with glaucoma severity in POAG patients. 15 The lack of association between IOP and age with glaucoma severity in our study may be explained by the cross-sectional design and small sample size.…”

Section: Discussionmentioning

confidence: 99%

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Association Between Ocular Biomechanics Measured With Corvis ST and Glaucoma Severity in Patients With Untreated Primary Open Angle Glaucoma

Chen

Sun

2022

Trans. Vis. Sci. Tech.

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Purpose To compare the ocular biomechanical differences between normal controls and patients with untreated primary open angle glaucoma, including normal-tension glaucoma (NTG) and high-tension glaucoma (HTG), and to investigate the association between ocular biomechanics and glaucoma severity in each group. Methods One hundred fifty-three eyes of 153 subjects, including 51 controls, 47 NTG, and 55 HTG cases, were enrolled in this cross-sectional study. Each participant underwent biomechanical measurements by using the Corneal Visualization Scheimpflug Technology. Glaucoma severity was evaluated by mean deviation (MD), pattern standard deviation (PSD), ganglion cell complex (GCC), and retinal nerve fiber layer (RNFL) thickness. Results Deformation amplitude ( P = 0.001) significantly increased, whereas first applanation time ( P < 0.0001), highest concavity time ( P = 0.001), stiffness parameter at first applanation ( P = 0.009), and time of whole eye movement (WEM, P = 0.008) decreased significantly in NTG eyes compared with controls. Besides, NTG had the highest first applanation velocity than controls ( P < 0.0001) and HTG ( P = 0.044). Shorter time of WEM was independently correlated with worse MD ( P = 0.02) and higher values of PSD ( P = 0.03) in NTG. Axial length was positively related to PSD ( P = 0.02) and negatively related to GCC ( P < 0.0001) and RNFL ( P < 0.0001) thickness in HTG. Conclusions NTG corneas are more deformable than healthy ones and HTG. Time of WEM, which relates to orbital compliance, is significantly associated with glaucomatous visual field defect in NTG, whereas axial length is correlated with glaucoma severity in HTG. Translational Relevance Ocular biomechanics may partly account for the differences of pathogenic mechanisms between NTG and HTG.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Association Between Ocular Biomechanics Measured With Corvis ST and Glaucoma Severity in Patients With Untreated Primary Open Angle Glaucoma

Chen

Sun

2022

Trans. Vis. Sci. Tech.

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“…However, no significant difference was observed in CH between the control and treatment-naïve POAG groups, with the AUC value as low as 0.59. Few studies have investigated CH in treatment-naïve glaucomatous eyes, some of which were lower than that in the current treatment-naïve POAG eyes (9.71 mmHg) 52,53 . A prospective study by Susanna et al indicated that CH is a risk factor for the development of glaucoma even when a multivariable model to adjust for the treatment was used 10 .…”

Section: Discussionmentioning

confidence: 60%

“…A prospective study by Susanna et al indicated that CH is a risk factor for the development of glaucoma even when a multivariable model to adjust for the treatment was used 10 . Boliver et al 52 found that CH (8.9 mmHg in average) was associated with the amount of VF damage in treatment-naïve OAG eyes. Prata et al 53 found an association between CH (8.1 mmHg in average) and optic nerve head morphology in untreated newly diagnosed patients with POAG.…”

Section: Discussionmentioning

confidence: 99%

Comparison of two analyzer measurements focusing on material stiffness among normal, treatment-naïve, and treated glaucoma eyes

Aoki

Asaoka

Fujino

et al. 2023

Sci Rep

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To investigate differences in biomechanical properties focusing on stiffness parameters between normal, treatment-naïve primary open-angle glaucoma (POAG), and treated POAG eyes. Retrospective case–control study, This study included 46 treatment-naïve POAG eyes, 46 POAG eyes treated with prostaglandin analogues, and 49 normal eyes used as controls; matched in terms of age and axial length. Corneal hysteresis (CH) and corneal resistance factor (CRF) were measured using an ocular response analyzer (ORA). Fifteen biomechanical parameters were measured with the Corneal Visualization Scheimpflug Technology (Corvis ST), including biomechanical glaucoma factor (BGF) and two stiffness parameters of ‘SP A1’ and ‘stress–strain index (SSI)’, which were compared among the three groups. Additionally, the area under the curve (AUC) values of the receiver-operating curve to discriminate control and treatment-naïve POAG eyes were calculated for BGF and CH. Treatment-naïve POAG eyes had higher ‘SSI’ than normal eyes even after controlling for IOP (p < 0.05, Tukey-Cramer test). Treated POAG eyes had significantly lower CRF, and higher BGF than treatment-naïve POAG eyes. There were also significant differences in CH or SP A1 among the three groups. BGF and CH had similar AUC values (0.61 and 0.59). Treatment-naïve POAG eyes had stiffer corneas compared to normal eyes, which seemed to result from the material/structure of the cornea rather than higher intraocular pressure. Antiglaucoma topical medication alters biomechanical properties measured with Corvis ST. These results are important for understanding the pathogenesis and improving the management of POAG.

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“…10 Boliver et al found that CH was associated with the amount of VF damage in treatment-naïve OAG eyes. 49 Prata et al found an association between CH and optic nerve head morphology in untreated newly diagnosed patients with POAG. 50 The entire reason for the contradictory results is unknown; however, it could be attributed to the difference in IOP levels.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Two Analyzer Measurements Focusing on Material Stiffness Among Normal, Treatment-naïve, and Treated Glaucoma Eyes

Aoki

Asaoka

Fujino

et al. 2022

Preprint

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Purpose: To investigate differences in biomechanical properties focusing on stiffness parameters between normal, treatment-naïve primary open-angle glaucoma (POAG), and treated POAG eyes.Design: Retrospective case-control studyMethods: This study included 46 treatment-naïve POAG eyes, 46 POAG eyes treated with prostaglandin analogues, and 49 normal eyes used as controls; matched in terms of age and axial length. Corneal hysteresis (CH) and corneal resistance factor (CRF) were measured using an ocular response analyzer (ORA). Fifteen biomechanical parameters were obtained with the Corneal Visualization Scheimpflug Technology (Corvis ST), including biomechanical glaucoma factor (BGF) and two stiffness parameters of ‘SP A1’ and ‘stress-strain index (SSI)’, which were compared among the three groups. Additionally, the area under the curve (AUC) values of the receiver-operating curve, to discriminate control and treatment-naïve POAG eyes were calculated and compared between CH and BGF.Results: Treatment-naïve POAG eyes had higher ‘SSI’ than normal eyes even after controlling for IOP (p<0.05, Tukey-Cramer test). Treated POAG eyes had significantly lower CRF, and higher BGF than treatment-naïve POAG eyes. There were insignificant differences in CH or SP A1 among the three groups. BGF and CH had no significantly different AUC values to discriminate between control and treatment-naïve POAG eyes (0.61 and 0.59).Conclusions: Treatment-naïve POAG eyes had stiffer corneas compared to normal eyes, which seemed to result from the material of the cornea rather than higher intraocular pressure. Antiglaucoma topical medication alters biomechanical properties measured with Corvis ST. These results are important for understanding the pathogenesis and improving the management of POAG.

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Corneal Factors Associated with the Amount of Visual Field Damage in Eyes with Newly Diagnosed, Untreated, Open-angle Glaucoma

Cited by 4 publications

References 17 publications

Association Between Ocular Biomechanics Measured With Corvis ST and Glaucoma Severity in Patients With Untreated Primary Open Angle Glaucoma

Association Between Ocular Biomechanics Measured With Corvis ST and Glaucoma Severity in Patients With Untreated Primary Open Angle Glaucoma

Comparison of two analyzer measurements focusing on material stiffness among normal, treatment-naïve, and treated glaucoma eyes

Comparison of Two Analyzer Measurements Focusing on Material Stiffness Among Normal, Treatment-naïve, and Treated Glaucoma Eyes

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