Corneal Erosions, Bacterial Contamination of Contact Lenses, and Microbial Keratitis

Abstract

The coincidence of corneal erosions during lens wear with gram-negative bacterial contamination of lenses may account for the relative incidence of MK during lens wear with different lens materials and modes of use.

Mechanical Complications Induced by Silicone Hydrogel Contact Lenses

“…24,72,73,87 The incidences of SEALs, corneal erosion, and CEFs are greater with EW/CW than with DW, but wearing modality does not seem to influence the incidences of mucin balls and CLPC. 26,37,71,86 Finally, the frequency of mucin balls, CLPC, CEFs, and meibomian gland dropout increases with duration of lens wear. 4,14,79,86,119 Despite the wealth of published information related to SiHy CLs, much more needs to be elucidated about their effects on lid wiper and meibomian gland anatomical and physiologic changes.…”

“…Compared with conventional hydrogel lenses, first-generation SiHy CLs are associated with greater severity of mucin balls and higher incidence of corneal erosion. 4,37 However, the lower-modulus second-generation SiHy lenses are associated with decreased occurrence of SEALs, CLPC, and CEFs. 24,72,73,87 The incidences of SEALs, corneal erosion, and CEFs are greater with EW/CW than with DW, but wearing modality does not seem to influence the incidences of mucin balls and CLPC.…”

“…31 Because of its quick resolution time and symptom-based diagnosis, CL-induced corneal erosion incidence rates have not been widely published, but they have been reported with gas-permeable (GP), conventional hydrogel, and SiHy lenses. 20,24,31,[36][37][38] A retrospective study published in 2010 serves as the most comprehensive report of incidence rates for various combinations of lens materials and wearing modalities. 37 The incidence of corneal erosion is greater with EW (0.60%-2.60% of visits) than with DW (0.01%-0.05% of visits) and greater with first-generation SiHy CLs (0.95%-1.68% of visits) than with conventional hydrogel lenses (0.05%-0.35% of visits).…”

Contact Lens Fitting and Long-Term Management for the Boston Keratoprosthesis

“…[16][17][18][19][20][21][22] Use of silicone hydrogel materials may increase oxygen to limbal structures, but this alone is not likely to eliminate the problems of lens fit and bioburden, which also plays a major role in corneal inflammation. [16][17][18][19][20][21][22] Use of silicone hydrogel materials may increase oxygen to limbal structures, but this alone is not likely to eliminate the problems of lens fit and bioburden, which also plays a major role in corneal inflammation.…”

Hydrogel Contact Lenses Surface Roughness and Bacterial Adhesion

“…Further, the new modalities of wear, such as daily disposable (DD) hydrogel CL, avoid the need for regular cleaning and storage, which are known to be an important cause of microbial contamination (Laughlin-Borlace et al, 1998). However, several studies have surprisingly shown that users of DD and silicone hydrogel CL do not show a reduced risk of MK Stapleton et al, 2008;Willcox et al, 2010). In effect, in the paper by Dart et al, differences in soft CL design and/or the composing polymer rather than the mode of wear were found to determine susceptibility to MK .…”