Corneal Epithelial Thinning Profile Induced by Long-Term Wear of Hydrogel Lenses

González, José Emilio Pardo; Méijome, José Manuel González; Jalbert, Isabelle; Sweeney, Deborah F.; Erickson, Paul

doi:10.1097/00003226-200305000-00005

Cited by 76 publications

(69 citation statements)

References 24 publications

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“…3,[6][7][8] Additionally, previously reported values on the OCT machine were similar, 9,10 like our study. However, until recently there were no reported differences between central and peripheral epithelial thicknesses.…”

Section: Epithelial Thicknesssupporting

confidence: 86%

Wide Corneal Epithelial Mapping Using an Optical Coherence Tomography

Hashmani¹,

Hashmani²,

Saad

2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To map the corneal epithelium using a map measuring 9 mm in diameter and view the effects of age, sex, and axial length. Additionally, we wanted to demonstrate the reproducibility of this technique. METHODS.We calculated the epithelial thickness in 220 individuals using an SD-OCT machine with the newly released commercially available algorithm. We included normal eyes with refractive errors between þ5 and À6 diopters (D). We excluded patients with an intraocular pressure of >22 mm Hg, history of cataract, previous ocular surgery, or disease and those with corneal pathology. Additionally, we excluded patients with evidence of systemic disease or pregnancy. Lastly, reproducibility was measured in 50 individuals. RESULTS.We found the center of the corneal epithelium to be thicker than the peripheral in all zones except the nasal (P ¼ 0.124). The superior quadrant was found to be the thinnest while the inferior was the thickest. Males had a thicker epithelium in all locations except the superior outer section (P ¼ 0.123). Three zones had a weak correlation with age: outer superior (P ¼ 0.039, R ¼ À0.152); outer temporal (P ¼ 0.042, R ¼ À0.150); and outer superior temporal (P ¼ 0.011, R ¼ À0.187). There was no significant relationship with the axial length. We found good to excellent reproducibility when using this technique in the central as well as the peripheral cornea.CONCLUSIONS. We provide a comprehensive study in healthy, normal eyes using a novel algorithm to map the corneal epithelium with a wide diameter. This study can be used as a reference for future research.

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Section: Epithelial Thicknesssupporting

confidence: 86%

Wide Corneal Epithelial Mapping Using an Optical Coherence Tomography

Hashmani¹,

Hashmani²,

Saad

2018

Invest. Ophthalmol. Vis. Sci.

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“…The epithelial thickness results for the low Dk group replicate previous findings. 3,5 Conversely, Patel et al could not demonstrate central epithelial thinning in long-term wearers of daily wear soft and rigid low Dk lenses. 6 Their study protocol included a minimal delay of 12-24 h between lens removal and confocal microscopy examination.…”

Section: Discussionmentioning

confidence: 94%

“…Soft lenses alter the epithelium in a myriad of ways. These include central [1][2][3][4][5] and peripheral 3,6 epithelial thinning, basal cell fragility, 7 reduced surface cell shedding, 1,2,8 and cell death, 1,9,10 reduced mitosis, 11 a lower number of epithelial cell layers, 4,7 and reduced oxygen uptake. 5 Increases in surface cell size, 1,2,8,[12][13][14][15] bacterial adhesion, 1,2,8 epithelial permeability, 16 and the number of microcysts 5,17 have also been observed.…”

Section: Introductionmentioning

confidence: 99%

The effect of long-term wear of soft lenses of low and high oxygen transmissibility on the corneal epithelium

Jalbert

Sweeney

Stapleton

2008

Eye

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Purpose To measure the effects of long-term wear of soft lenses of low and high oxygen transmissibility (Dk) on basal epithelial appearance and epithelial thickness. Methods Sixty-three subjects were enroled in a cross-sectional study. Seventeen high Dk lens wearers and 24 low Dk lens wearers who had worn lenses on an extended wear basis for more than 3 years (range: 3-22) were compared to a group of 22 age-matched subjects who had never worn contact lenses. Cell regularity and the intensity of light backscattered by the basal epithelium were assessed using confocal microscopy. Epithelial thickness was measured at the centre and at four peripheral locations using modified optical pachometry. Results Epithelial basal cells appeared less regular in low Dk lens wearers than high Dk wearers or controls (Mann-Whitney U-test, P ¼ 0.001). The intensity of backscattered light did not differ across groups (Kruskal-Wallis test, P ¼ 0.37). Low Dk wearers had the thinnest epithelium (46 (10) mm), followed by high Dk wearers (54 (14) mm) and controls (58 (9) mm; ANOVA, Pp0.006). Topographical position did not affect epithelial thickness (ANOVA, P ¼ 0.10). Conclusions Visible alterations to the basal epithelial cells can only be detected in longterm extended wearers of low Dk soft lenses. Extended wear of high Dk soft lenses results in topographically uniform epithelial thinning that is significantly less than the thinning seen with low Dk lenses. Confirmation of these findings using groups with evenly matched duration of lens wear is required.

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“…Adequate oxygen is a necessary factor in the highly regulated process of corneal epithelial renewal. [10] Pérez et al [12] postulated that low oxygen levels suppress the aerobic epithelial metabolism which in turn affects cell renewal.…”

Section: Discussionmentioning

confidence: 99%

Histomorphological changes in the cornea of the rat following monocular eyelid closure

Aseta¹,

Mwachaka²,

Odula³

et al. 2016

Anatomy

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Objectives:The aim of this study was to describe structural changes in the cornea of the rat after monocular eyelid closure.Methods: Twenty-six Rattus norvegicus male rats aged three months were used. The rats were randomly assigned into baseline (2), experimental (16) and control (8) groups. Unilateral eyelid closure was performed on the experimental animals by suture tarsorrhaphy. At experiment days 5, 10, 15 and 20, four rats from the experimental group and two rats from the control group were euthanized, their eyeballs harvested, and routine processing was done for paraffin embedding, sectioning and Masson's trichrome staining. The photomicrographs were taken using a digital photomicroscope.Results: In the closed eyes, there was a time-dependent reduction in the stratification of the corneal epithelium with subsequent disintegration, and an increase in distribution of stromal keratocytes while the corneal endothelial cells showed slight enlargement from squamous shape. The contralateral and control eyes did not exhibit any significant changes through the experimental period. Conclusion:Monocular eyelid closure causes structural changes in the corneal epithelium, stroma and endothelium of the tarsorrhaphy eye. Therefore, tarsorrhaphy should not be prolonged due to risk of corneal diseases and diminution of vision as a result of the structural changes.

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Corneal Epithelial Thinning Profile Induced by Long-Term Wear of Hydrogel Lenses

Abstract: This study establishes that the epithelial thinning associated with hydrogel lens wear is topographically uniform. It also confirms that this effect is inversely related to lens oxygen transmissibility but does not appear to increase with longer duration of wear.

Cited by 76 publications

References 24 publications

Wide Corneal Epithelial Mapping Using an Optical Coherence Tomography

Wide Corneal Epithelial Mapping Using an Optical Coherence Tomography

The effect of long-term wear of soft lenses of low and high oxygen transmissibility on the corneal epithelium

Histomorphological changes in the cornea of the rat following monocular eyelid closure

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