Corneal endothelial changes after posterior chamber intraocular lens implantation in patients with or without diabetes mellitus.

Furuse, Nanako; Hayasaka, Seiji; Yamamoto, Yukio; Setogawa, Tomoichi

doi:10.1136/bjo.74.5.258

Cited by 17 publications

(7 citation statements)

References 12 publications

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“…However, our calculations didn't show any significant difference in ECD between diabetic and control groups. This is coincide with results published by Furuse et al who could not demonstrate the significant changes in mean density of corneal endothelial cells in diabetic subjects of type 2 diabetes mellitus [25].…”

Section: Discussionsupporting

confidence: 93%

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Corneal Measurements in patients with Diabetes Mellitus

Huseynova¹,

Galbinur²,

Abdullayev³

et al. 2016

Azerbaijan Med Assoc J

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Purpose: To estimate the corneal measurements using Scheimpflug camera in patients with diabetes mellitus.Methods: Twenty five diabetic patients were prospectively recruited. Two groups were stratified, diabetic group and control group. Central corneal thickness (CCT), keratometry values (Kmean and Kmax), corneal volume (CV), anterior chamber depth (ACD), anterior chamber volume (ACV), Qvalue, frontal and back elevation, and the parameters of corneal variance indices, including minimum radius (Rmin) were measured using Pentacam Scheimpflug camera. Endothelial cell density (ECD) was also recorded. Findings were evaluated and compared between the 2 groups.Results: Two groups were found to have different Kmax (P = 0.03, one-tailed) and Rmin (P = 0.04, one-tailed) parameters. There was no statistical significant difference between the 2 groups in CCT, Kmean, CV, ACD, ACV, frontal/back elevation, Qvalue, ECD, and parameters of corneal variance indices.Conclusions: Diabetes mellitus affects keratometry and radius values of the human cornea based on the corneal measurements from Scheimpflug camera.

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Section: Discussionsupporting

confidence: 93%

“…Corneal changes are diagnosed in about 70% of adult patients with diabetes (24,25). The purpose of this study was to estimate the effect of DM on the corneal measurements.…”

Section: Discussionmentioning

confidence: 99%

Corneal Measurements in patients with Diabetes Mellitus

Huseynova¹,

Galbinur²,

Abdullayev³

et al. 2016

Azerbaijan Med Assoc J

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“…They concluded that neither type 1 diabetes patients nor type 2 diabetes patients differed from their controls in ECD but type 1 diabetes patients had thicker corneas. Furthermore, Furuse et al [27] did not demonstrate significant changes in mean ECD in diabetic subjects, but they only examined patients with type 2 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Corneal Endothelial Morphology in Children with Type 1 Diabetes

Anbar

Ammar

Mahmoud

2016

Journal of Diabetes Research

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Aim. To investigate corneal endothelial cell morphological in children with type 1 diabetes and to determine the systemic and local factors that contribute to these changes. Methods. One hundred sixty eyes of 80 children with type 1 diabetes and 80 eyes of 40 normal children as a control during the period from July 2015 to February 2016 underwent full clinical and ophthalmologic examination. We measured the central corneal thickness (CCT), endothelial cell density (ECD), ploymegathism, and pleomorphism using a noncontact specular microscope. Results. The mean age of the diabetic children was 8.22 ± 3.11 years. The mean duration of type 1 diabetes was 3.51 ± 2.23 years. The mean CCT was significantly higher: 537 ± 33.41 microns (right eye), in the diabetic group compared to the control group. The mean ECD in patients with type 1 diabetes was 3149.84 ± 343.75 cells/mm2 (right eye), and it was significantly lower than in the control group. Furthermore, pleomorphism was significantly lower 48.73 ± 5.43% (right eye), in the diabetic group compared to the control group. The mean polymegathism was significantly higher 37.96 ± 5.61% (right eye), in the diabetic group compared to the control group. All of these changes are significantly correlated only with the duration of diabetes. Conclusions. Diabetic children have thicker corneas, lower ECD, an increased polymegathism, and a decreased pleomorphism. The duration of diabetes is the factor that affects all of these changes. To what extent these changes affect visional function on long term needs to be investigated in further studies.

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“…We have to remember that our diabetic and non-diabetic subjects were young: the mean age in diabetic group was 15.34 ± 3.06 years versus 14.58 ± 2.01 years in control group. Different observations were done by Furuse et al, who did not demonstrate significant changes in mean density of corneal endothelium cells in diabetic subjects, but they only examined patients with type 2 diabetes [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Corneal Endothelium in Children and Adolescents with Type 1 Diabetes Mellitus

Urban

Raczyńska

Bakunowicz-Łazarczyk

et al. 2013

Mediators of Inflammation

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Purpose. To evaluate the systemic and local factors that contribute to the damage of endothelial cells in diabetic patients and to compare the endothelial structure of the cornea in diabetic and nondiabetic patients. Materials and Methods. The endothelial cell density (ECD) and central corneal thickness (CCT) were investigated in 123 eyes of type 1 diabetic patients and in 124 eyes of nondiabetic patients. The mean diabetic patients age was 15.34 ± 3.06 years versus 14.58 ± 2.01 years in the control group. The mean duration of diabetes was 8.02 ± 3.9 years. The corneal endothelium was imaged by the Topcon SP-2000P. Results. The mean ECD in diabetic eyes was 2435.55 ± 443.43 cells/mm2 and was significantly lower than in control group (2970.75 ± 270.1 cells/mm2). The mean CCT was 0.55 ± 0.03 mm in diabetic group versus 0.53 ± 0.033 mm in control group. ECD and CCT significantly correlated only with duration of diabetes. There was no correlation between ECD and CCT and patient age, sex, HbA1C level, and plasma creatinine level. Conclusions. ECD is decreased and CCT is increased in children and adolescents with diabetes mellitus. Duration of diabetes is the factor that affects ECD and CCT.

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Corneal endothelial changes after posterior chamber intraocular lens implantation in patients with or without diabetes mellitus.

Cited by 17 publications

References 12 publications

Corneal Measurements in patients with Diabetes Mellitus

Corneal Measurements in patients with Diabetes Mellitus

Corneal Endothelial Morphology in Children with Type 1 Diabetes

Evaluation of Corneal Endothelium in Children and Adolescents with Type 1 Diabetes Mellitus

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