Corneal Measurements in patients with Diabetes Mellitus

Huseynova, Tukezban; Galbinur, Tural; Abdullayev, Anar; Rahimzade, A.

doi:10.5455/amaj.2016.02.019

Cited by 3 publications

(10 citation statements)

References 25 publications

(37 reference statements)

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“…This study showed that CCT and corneal radius of curvature were similar in both group [33] . Other studies also reported that CCT, corneal curvature, and corneal asphericity in both types of diabetes were not different from the non-diabetic group [13,[34][35] . Inconsistent with our results, studies have shown that in diabetic patients the cornea is thicker than the non-diabetic group [14,[36][37] .…”

Section: Resultsmentioning

confidence: 80%

“…According to a study, anterior segment parameters like ACD, corneal volume (CV), K mean, CCT, and corneal asphericity except smallest radius of curvature in entire field measurement (Rmin) were similar between the non-diabetic and diabetic groups. Diabetic patients had higher keratometric findings than the non-diabetic group [13] . Although several studies stated that diabetic patients have thicker cornea than non-diabetic subjects [14,[18][19] , some studies did not report any difference between the two groups [13,20] .…”

Section: Introductionmentioning

confidence: 71%

“…Diabetic patients had higher keratometric findings than the non-diabetic group [13] . Although several studies stated that diabetic patients have thicker cornea than non-diabetic subjects [14,[18][19] , some studies did not report any difference between the two groups [13,20] . There are also contradictory results about hyperglycemia-related changes of corneal densitometry, asphericity, and keratometry [13,[21][22] .…”

Section: Introductionmentioning

confidence: 71%

“…In addition, intraocular pressure (IOP) measurement which is the only causal and treatable risk factor for glaucoma also affected by corneal characteristics especially central corneal thickness (CCT) [12] . Several studies showed that some changes happen in the anterior segment of the eye following DM [13][14][15][16][17] . Han et al [15] compared the corneal nerve and ocular surface changes between healthy normal individuals and patients with type 2 DM in different stages of DR.…”

Section: Introductionmentioning

confidence: 99%

“…Although several studies stated that diabetic patients have thicker cornea than non-diabetic subjects [14,[18][19] , some studies did not report any difference between the two groups [13,20] . There are also contradictory results about hyperglycemia-related changes of corneal densitometry, asphericity, and keratometry [13,[21][22] . In addition to the contradictory results of the studies and limited sample size, previous studies evaluated limited corneal parameters.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of anterior segment parameters of the eye between type 2 diabetic with and without diabetic retinopathy and non-diabetic

Narooie-Noori¹,

Mirzajani²,

Jafarzadehpur³

et al. 2023

Int J Ophthalmol

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AIM: To compare anterior segment parameters between two groups of type 2 diabetic with and without diabetic retinopathy (DR) and non-diabetic elderly subjects based on hemoglobin A1c (HbA1c) levels and status of DR. METHODS: This study was conducted on 997 residents aged 60y or over in Tehran, Iran. Diabetic group had HbA1c level ≥6.4% with no other systemic problems. The non-diabetic participants had normal eye findings and no systemic diseases. K1, K2, mean K, Q-value, anterior, central, posterior, and total corneal densitometric findings, anterior chamber volume (ACV), anterior chamber depth (ACD), corneal volume (CV), and pachymetry were measured by Pentacam AXL. RESULTS: A total of 678 non-diabetic (39% male) and 319 diabetic (35% male) subjects with mean age of 66.31±5.23 and 67.22±4.96y were examined, respectively. No statistically significant difference was found in anterior segment parameters between non-diabetic and diabetic groups (all P>0.05). However, middle, posterior, and total corneal densitometric values were statistically different between two groups after controlling the effects of confounders (P=0.014, 0.007, and 0.042, respectively). Corneal densitometric values in all layers, ACD, and ACV were different between diabetic subjects with and without DR (all P<0.05). In the diabetic group, only corneal densitometric values had a negative relationship with fasting blood sugar (P<0.001). ACD and ACV had a negative correlation with HbA1c levels (all P<0.05, r=-0.129 and -0.146, respectively). However, the relationships were not observed after controlling the confounders (P=0.938, 0.466, respectively). CONCLUSION: Considering the higher densitometric values of the cornea and lower ACD and ACV in diabetic subjects with DR, it is suggested that the examiners should perform comprehensive retinal examinations when faced with such conditions.

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Section: Resultsmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Comparison of anterior segment parameters of the eye between type 2 diabetic with and without diabetic retinopathy and non-diabetic

Narooie-Noori¹,

Mirzajani²,

Jafarzadehpur³

et al. 2023

Int J Ophthalmol

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Corneal topographic indices of scheimpflug camera in type 2 diabetic and non-diabetic elderly populations

Hashemi,

Khabazkhoob,

Narooei

et al. 2023

BMC Ophthalmol

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Purpose The present study was conducted to determine the corneal topographic indices of Scheimpflug camera in type 2 diabetes patients without diabetic retinopathy (DR), DR and non-diabetic elderly populations. Methods A total of 1105 participants were selected using random cluster sampling from Tehran, Iran and categorized into three groups including type 2 diabetes patients without diabetic retinopathy (DR), DR and non-diabetic. The diabetic group had HbA1c levels ≥ 6.4% with no other systemic problems. The non-diabetic participants had normal eye findings and no systemic diseases. The pachymetric progression index (PPI) values were measured using the Pentacam AXL. Results A total of 1105 participants including 429 diabetes patients (38.46% male) and 676 non-diabetic (38.76% male) subjects entered the study. Only PPIavg and PPImax were higher in the diabetics versus non-diabetics (P = 0.019 and 0.010, respectively). There was a significant difference in PPImax between the three groups (P = 0.036). There were significant differences only in index of vertical asymmetry (IVA), central keratoconus index (CKI), PPI average, and PPI max between different stages of diabetic retinopathy (DR) (P = 0.045, 0.005, 0.002, and 0.004, respectively). There was a significant difference in index of Surface Variance (ISV), index of vertical asymmetry (IVA), PPIavg, and PPImax between diabetes patients with and without DR (P = 0.016, 0.022, < 0.001, and < 0.001, respectively). Conclusion According to the results, diabetes and DR change several topographic indices. In addition, the HbA1c level may affect pachymetric progression index max. Therefore, special attention should be paid to these patients for different treatment strategies.

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Identification of genes in a genomic DNA sequence

Mammadova,

Huseynova

2023

InterConf+

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Today, newer pyrosequencing methods have drastically cut the cost of sequencing and may eventually allow every person the possibility of personalized genome information. Being able to read how our genes are expressed offers the promise of advanced medical treatments, but it will certainly require considerable work to generate, understand, organize, and apply this massive amount of data to human disease. This study describes the results of the CFTR, MEFV, GALT, PAH, BCKDHB and DBT genes analysis of Azerbaijanian patients. The molecular diagnostics methods using specific primers to identify CFTR, MEFV, GALT, PAH, BCKDHB and DBT genes many mutations. A total 15 different mutations (R261Q, V245V, P281L, R241C, L385L, V399V, E280K, R261X, A434D, R176X, Ex6-96A> G, R241C, R243Q, R252Q, Y356X) and 2 different polymorphisms (Q232Q,V245V) were detected of the PAH gene. 4 different mutations (P325L, H132Q, Q334K, N314D ) were detected of the GALT gene, 6 different mutations (Phe508del, Phe508del/5T, R117H/R334W, R553X and 965 (T-C)) were found in the CFTR gene, polymorphisms (D102D, G138G, A165A, R202Q, R314R, G474G, G476G, D510D) were detected of the MEFV gene, 2 different mutations were found of the BCKDHB gene and one mutation detected of the DBT gene in patients from Azerbaijani population. To prophylaxis the phenylketonuria, galactosemia, maple syrup urine disease, cystic fibrosis disease and Fammilian Mediterranian Fever it is recommended to screen genetically newborns, to consult medical-genetically risky families, and to carry out prenatal diagnostics during pregnancies for those families.

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Corneal Measurements in patients with Diabetes Mellitus

Cited by 3 publications

References 25 publications

Comparison of anterior segment parameters of the eye between type 2 diabetic with and without diabetic retinopathy and non-diabetic

Comparison of anterior segment parameters of the eye between type 2 diabetic with and without diabetic retinopathy and non-diabetic

Corneal topographic indices of scheimpflug camera in type 2 diabetic and non-diabetic elderly populations

Identification of genes in a genomic DNA sequence

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