Corneal endothelial cell density in healthy Caucasian population

Çevik, Mediha Tok; Çevik, Sadık Görkem; Duman, Rahmi; Perente, İrfan

doi:10.1016/j.sjopt.2016.10.003

Cited by 35 publications

(33 citation statements)

References 19 publications

(27 reference statements)

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“…Phacoemulsification is one of the most widely used surgical procedures for removal of cataract 9,10 . The corneal endothelium is known to undergo damage during phacoemulsification due to incision, use of ultrasonic energy, irrigation solutions, visco-elastics, etc 11 .…”

Section: Introductionmentioning

confidence: 99%

Change in Central corneal thickness after Phacoemulsification

Wali¹,

Surhio²,

Talpur³

et al. 2020

pak J Ophthalmol

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Purpose: To determine changes in central corneal thickness after phacoemulsification at first post-operative day, one week and one month. Study Design: Descriptive Observational study. Place and Duration of Study: Sindh Institute of Ophthalmology and Visual Sciences, Hyderabad. From June 2018 to March 2019. Material and Methods: Ninety-two patients with ages between 35 and 72 years presenting with senile and pre-senile cataract were selected by non-probability convenience sampling. Patients with previous ocular surgery, ocular trauma, Glaucoma, Uveitis, Contact lens wear and long-term use of ocular medication were excluded. The patients were subdivided into three groups depending on variability in their corneal thickness. Patients with preoperative central corneal thickness (CCT) from 480 to 529µm were placed in group 1 (Thin), group 2 included patients with CCT ranging between 530 and 569µm (Moderate), patients with CCT from 570-640µm were placed in group 3 (Thick). Preoperative CCT was measured before extraction of cataract via phacoemulsification and then repeated on first post-operative day and then on one week and one month. Results: Preoperative mean central corneal thickness increased by 10.2% on first post-operative day. It reduced to 3.1% on seventh post-operative day. It further reduced to 0.7% on 30th post-operative day. Central corneal thickness reduced to mean value of 548.8µm on 30th post-operative day, which was statistically non-significant as compared with preoperative mean value (544.96µm). Conclusion: There was no statistically significant change in CCT one month after phacoemulsification when compared with the pre-operative CCT.

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Section: Introductionmentioning

confidence: 99%

Change in Central corneal thickness after Phacoemulsification

Wali¹,

Surhio²,

Talpur³

et al. 2020

pak J Ophthalmol

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“…Обсуждение В настоящее время в клинической практике используют несколько разновидностей бесконтактных эндотелиальных микроскопов различных производителей, позволяющих проводить точную и безопасную для пациента оценку состояния эндотелиального слоя роговицы. Каждый из этих приборов имеет свои технологические особенности, программное обеспечение и способность работать в автоматическом и/или полуавтоматическом режимах, что в конечном счёте отражается в цифровых величинах результатов исследований, а также в их повторяемости [23][24][25][26][27]. В нашем исследовании морфологию роговичного эндотелия оценивали при помощи бесконтактного эндотелиального микроскопа (ЭМ) ЕМ 935 (Haag Streit, Швейцария) в полуавтоматическом режиме.…”

Section: результаты исследованияunclassified

“…Однако не было выявлено корреляционных взаимоотношений между возрастом и полимегатизмом, а также возрастом и гексагональностью роговичного эндотелия [23]. По данным разных исследователей, средняя плотность эндотелия роговицы у здоровых представителей европейской популяции в возрасте старше 50 лет составляет 2200-2600 кл/мм 2 [23,24,26,30]. Кроме того, в популяции старше 70 лет увеличивается риск уменьшения ПЭ до 2000 кл/мм 2 .…”

Section: результаты исследованияunclassified

“…Гексагональные клетки, тесно связанные между собой и образующие своеобразную сеть, обеспечивают устойчивость и постоянство эндотелиального слоя при растяжении, особенно при снижении ПЭ, а также создают барьер для прохождения водянистой влаги со стороны передней камеры, поддерживая тем самым строму в состоянии относительной дегидратации и обеспечивая точность прохождения света сквозь слои роговицы [38]. Считается, что в здоровой роговице взрослого человека его содержание должно быть не менее 60 % [23,24,26].…”

Section: результаты исследованияunclassified

“…C возрастом отмечается физиологическое незначительное увеличение коэффициента вариации клеток. При этом уровень полимегатизма в норме не должен превышать 30 % [23,24,26]. Следовательно, с учётом данных о снижении ПЭ у пациентов с наличием ПЭГ и ПОУГ мы можем ожидать у них повышения уровня полимегатизма.…”

Section: результаты исследованияunclassified

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Morphological features of the corneal endothelium in patients with pseudoexfoliative glaucoma

Beletskaya

Станиславовна²,

Astakhov

et al. 2018

Ophthalmology Reports

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Purpose. To study the main morphological features of the corneal endothelium in patients with pseudoexfoliative glaucoma (PEG). Methods. We included 193 subjects aged from 55 to 75 years. The main study group (PEG) included 96 patients (192 eyes), the primary open angle glaucoma (POAG) group included 36 patients (72 eyes) with POAG, the PEX group included 31 patients (62 eyes) with pseudoexfoliation syndrome without glaucoma. The control group consisted of 30 healthy subjects (60 eyes). Main corneal endothelium parameters were evaluated using a non-contact endothelial microscope EM-935 (Haag Streit, Switzerland). Data were analyzed by STATISTICA 9 software for Windows. Results. The patients with PEG had lower endothelial cell density (ECD) in comparison to the control group (p < 0.01), and PEX group (p < 0.05). The polymegatism level in patients with PEG and POAG was higher than in the control group (p < 0.001, and p < 0.01, correspondingly). In patients with moderate and advanced PEG, the ECD was significantly lower (p < 0.01), and the polymegatism level was significantly higher (p < 0.01) than the same parameters in patients with early PEG. The lowest ECD and the highest polymegatism percentage were observed in PEG patients with more pronounced PEX manifestations, p < 0.05. No effect of IOP-lowering eye drops on the corneal endothelium parameters was revealed, p < 0.05. Conclusions. Significant morphological changes of the corneal endothelium (decreased endothelial cell density, increased polymegatism percentage) were revealed in patients with PEG. It was established that the severity of these changes is associated with the PEG and PEX severity. No effect of IOP-lowering eye drops on the corneal endothelium parameters was detected.

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An eye on the dog as the scientist's best friend for translational research in ophthalmology: Focus on the ocular surface

Sebbag

Mochel

2020

Medicinal Research Reviews

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Preclinical animal studies provide valuable opportunities to better understand human diseases and contribute to major advances in medicine. This review provides a comprehensive overview of ocular parameters in humans and selected animals, with a focus on the ocular surface, detailing species differences in ocular surface anatomy, physiology, tear film dynamics and tear film composition. We describe major pitfalls that tremendously limit the translational potential of traditional laboratory animals (i.e., rabbits, mice, and rats) in ophthalmic research, and highlight the benefits of integrating companion dogs with clinical analogues to human diseases into preclinical pharmacology studies. This One Health approach can help accelerate and improve the framework in which ophthalmic research is translated to the human clinic. Studies can be conducted in canine subjects with naturally occurring or noninvasively induced ocular surface disorders (e.g., dry eye disease, conjunctivitis), reviewed herein, and tear fluid can be easily retrieved from canine eyes for various bioanalytical purposes. In this review, we discuss common tear collection methods, including capillary tubes and Schirmer tear strips, and provide guidelines for tear sampling and extraction to improve the reliability of analyte quantification (drugs, proteins, others).

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Corneal endothelial cell density in healthy Caucasian population

Cited by 35 publications

References 19 publications

Change in Central corneal thickness after Phacoemulsification

Change in Central corneal thickness after Phacoemulsification

Morphological features of the corneal endothelium in patients with pseudoexfoliative glaucoma

An eye on the dog as the scientist's best friend for translational research in ophthalmology: Focus on the ocular surface

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