Corneal densitometry in high myopia

Dong, Jing; Zhang, Yaqin; Zhang, Haining; Jia, Zhijie; Zhang, Suhua; Sun, Bin; Han, Yongqing; Wang, Xiaogang

doi:10.1186/s12886-018-0851-x

Cited by 27 publications

(22 citation statements)

References 24 publications

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“…We hypothesize that the surgical operation may slightly compromise the transparency of the peripheral cornea. Dong et al [30] investigated the differences in corneal densitometry between high myopic patients and normal individuals and found that densitometry values of the high myopic patients were significantly lower than those of the normal individuals. The authors hypothesize that the natural loss of endothelial cell density in a high myopic population might lead to a decrease in corneal densitometry.…”

Section: Discussionmentioning

confidence: 99%

One-year natural course of corneal densitometry in high myopic patients after implantation of an implantable collamer lens (model V4c)

Chen

Shen

et al. 2020

BMC Ophthalmol

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Background: Corneal densitometry, which is also known as corneal backscattering, is a surrogate measure of corneal clarity. The purpose of the study was to investigate the changes in corneal densitometry (CD) after implanting an implantable collamer lens (ICL-V4c). Method: Twenty-six high myopic patients (aged 29.3 ± 6.6 years, 6 males and 20 females) who underwent ICL-V4c implantation were enrolled. Intraocular pressure (IOP), corneal topography, corneal densitometry, uncorrected distance visual acuity (UCDVA), manifest refraction, and best corrected distance visual acuity (BCDVA) were evaluated preoperatively and at 1 day, 1 week, and 1, 3, 6, and 12 months post-operatively. Endothelial cell density (ECD) was measured pre-operatively and at 3, 6, and 12 months post-operatively. The efficacy index (mean post-operative UCDVA / mean pre-operative BCDVA) and the safety index (mean post-operative BCDVA / mean pre-operative BCDVA) were evaluated at 1 month, 3 months, 6 months and 12 months post-operatively. Results: Over the annular diameters of 0-2 mm, the pre-operative densitometry values of the anterior layer, central layer, posterior layer, and total layer were 20.1 ± 2.8, 11.8 ± 1.1, 10.5 ± 0.9 and 14.1 ± 1.5, respectively. From pre-operatively to post-operative Month 12, the values changed insignificantly (P = 0.177, P = 0.153, P = 0.543 and P = 0.207, respectively). Over the annular diameters of 2-6 mm, the pre-operative mean densitometry values were 17.9 ± 2.2, 10.5 ± 0.9, and 12.6 ± 1.2, respectively. From pre-operatively to post-operative Month 12, the values decreased to 16.5 ± 2.1, 10.0 ± 0.9, and 11.9 ± 1.2, respectively, which were similar to the pre-operative values (all P > 0.05) but significantly lower than the values obtained at post-operative Day 1 (P = 0.013, P = 0.002 and P = 0.010, respectively). The densitometry value of the posterior layer over the annular diameters of 2 to 6 mm remained unchanged (from 9.4 ± 0.7 to 9.1 ± 0.7) over time (P = 0.372). The efficacy and safety indices assessed at 12 months post-operatively were 1.04 ± 0.27 and 1.19 ± 0.23, respectively. The changes in IOP and ECD values were statistically insignificant (P = 0.896 and P = 0.968, respectively). Conclusion: ICL-V4c implantation may be safe and efficient for high ametropia correction. The corneal densitometry values obtained over the annulus of 0-6 mm increased slightly from before the operation to post-operative Day 1 and then decreased gradually, which indicates that ICL-V4c implantation may not compromise corneal clarity.

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Section: Discussionmentioning

confidence: 99%

One-year natural course of corneal densitometry in high myopic patients after implantation of an implantable collamer lens (model V4c)

Chen

Shen

et al. 2020

BMC Ophthalmol

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“…In agreement with other studies, we found significant correlation between increasing age and corneal densitometry, particularly in the more peripheral cornea. There was no relationship between age and densitometry in the central 0–2 mm annulus [ 5 , 45 , 51 ]. The stronger relationship between age and changes to densitometry in the peripheral cornea is likely due to a higher prevalence of age-related corneal changes in this region.…”

Section: Discussionmentioning

confidence: 99%

“…Scheimpflug densitometry is an objective, non-invasive method of measuring corneal density and thickness, providing quantitative maps with excellent repeatability [ 5 , 44 , 45 , 46 , 47 , 48 ]. Scheimpflug devices also provide information on corneal curvature across the corneal surface.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Corneal Thickness, Densitometry and Curvature on Intraocular Pressure Measurements Obtained by Applanation, Rebound and Dynamic Contour Tonometry

Junior

Augusto²,

Gracitelli

et al. 2020

Vision

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Evaluate the effect of corneal thickness, densitometry and curvature on intraocular pressure (IOP) measurements obtained by Goldmann applanation tonometry (GAT), non-contact tonometry (NCT), rebound tonometry (RT), and dynamic contour tonometry (DCT). A cross-sectional prospective study involving 40 participants was performed. Corneal measurements were obtained using Pentacam (Oculus GMbH, Wetzlar, Germany), densitometry was measured at annuli of 0–2, 2–6, 6–10 and 10–12 mm. The relationship between corneal thickness (central, 4 and 6 mm), corneal astigmatism and corneal densitometry and IOP was examined. There was a significant relationship between corneal thickness (central, 4 and 6 mm) and GAT180, GAT90, RT, and NCT (P < 0.001 for all comparisons) but not for DCT. Higher corneal densitometry (6–10 mm and 10–12 mm zones) was associated with higher IOP from GAT180 and GAT90, and higher densitometry in the 6–10 mm zone correlated with higher IOP from NCT, however corneal densitometry increased with age. Accounting for age, the relationship between corneal densitometry and IOP measurements was not significant. In eyes with greater corneal astigmatism there was a greater difference between GAT90 and GAT180 measurements. IOP measurements may be affected by corneal thickness, densitometry and curvature. DCT was less affected by properties of the cornea compared to other devices.

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“…The recent studies (since 2015), which have analyzed the mechanical corneal properties in relation with the cell density of the corneal endothelium, have been unable to show a statistically significant correlation [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Correlations between corneal biomechanics and specular microscopy in patient with cataract

Iancu

Bujor

Iliuţă

et al. 2020

rjo

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This study aimed to analyze the connection between corneal biomechanics (corneal hysteresis, CH) and endothelial cell density of cornea (mean endothelial cell density, MCD) in patients diagnosed with cataract. This retrospective, observational study was performed in the Ophthalmology Clinic of the University Emergency Hospital in Bucharest. Of 60 patients (120 eyes) with cataract, who were included in this study, we analyzed the CH values obtained using with the Ocular Response Analyzer (ORA) and the MCD values obtained using the specular microscopy. The study groups comprised both men and women with ages ranging from 45 to 63 years. Patients were divided into three study groups according to CH values. In each batch, the CH values obtained with the Ocular Response Analyzer (ORA) were correlated with age, gender and MCD, then the subgroups were compared. All the data gathered showed no correlation to be statistically significant regarding the biomechanical properties of the cornea and the corneal endothelial cell density in patients with cataract.

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Corneal densitometry in high myopia

Cited by 27 publications

References 24 publications

One-year natural course of corneal densitometry in high myopic patients after implantation of an implantable collamer lens (model V4c)

One-year natural course of corneal densitometry in high myopic patients after implantation of an implantable collamer lens (model V4c)

The Effect of Corneal Thickness, Densitometry and Curvature on Intraocular Pressure Measurements Obtained by Applanation, Rebound and Dynamic Contour Tonometry

Correlations between corneal biomechanics and specular microscopy in patient with cataract

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