Correlations between corneal biomechanics and specular microscopy in patient with cataract

Iancu, Raluca; Bujor, Inna; Iliuţă, C; Tudor, Ștefania; Ungureanu, Emil; Pașca, Irena Gabriela; Istrate, Sînziana

doi:10.22336/rjo.2020.25

Cited by 2 publications

(1 citation statement)

References 44 publications

(22 reference statements)

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“…Our study has found statistically significant, moderate-to-strong correlations between CH and CRF and endothelial cell count and variability. However, to the best of our knowledge, these findings differ from those in the literature, where no significant correlation has been found between biomechanical and endothelial corneal parameters in healthy volunteers [ 39 ] or in patients with cataract [ 40 ]. As the level of corneal hydration, which is regulated by the endothelial pump function, may influence corneal biomechanics [ 39 ], more studies are needed in order to identify the factors that modulate the relationship between CH, CRF and endothelium parameters.…”

Section: Discussioncontrasting

confidence: 99%

Particular Anatomy of the Hyperopic Eye and Potential Clinical Implications

Marinescu,

Dascalescu,

Constantin

et al. 2023

Medicina

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Background and Objectives: Hyperopia is a refractive error which affects cognitive and social development if uncorrected and raises the risk of primary angle-closure glaucoma (PACG). Materials and Methods: The study included only the right eye—40 hyperopic eyes in the study group (spherical equivalent (SE) under pharmacological cycloplegia over 0.50 D), 34 emmetropic eyes in the control group (SE between −0.50 D and +0.50 D). A complete ophthalmological evaluation was performed, including autorefractometry to measure SE, and additionally we performed Ocular Response Analyser: Corneal Hysteresis (CH), Corneal Resistance Factor (CRF); specular microscopy: Endothelial cell density (CD), Cell variability (CV), Hexagonality (Hex), Aladdin biometry: Anterior Chamber Depth (ACD), Axial Length (AL), Central Corneal Thickness (CCT). IBM SPSS 26 was used for statistical analysis. Results: The mean age of the entire cohort was 22.93 years (SD ± 12.069), 66.22% being female and 33.78% male. The hyperopic eyes had significantly lower AL, ACD, higher SE, CH, CRF. In the hyperopia group, there are significant, negative correlations between CH and AL (r −0.335), CRF and AL (r −0.334), SE–AL (r −0.593), ACD and CV (r −0.528), CV and CRF (r −0.438), CH (r −0.379), and positive correlations between CCT and CH (r 0.393) or CRF (r 0.435), CD and ACD (r 0.509) or CH (0.384). Age is significantly, negatively correlated with ACD (r −0.447), CH (r −0.544), CRF (r −0.539), CD (r −0.546) and positively with CV (r 0.470). Conclusions: Our study suggests a particular biomechanical behavior of the cornea in hyperopia, in relation with morphological and endothelial parameters. Moreover, the negative correlation between age and ACD suggests a shallower anterior chamber as patients age, increasing the risk for PACG.

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Section: Discussioncontrasting

confidence: 99%

Particular Anatomy of the Hyperopic Eye and Potential Clinical Implications

Marinescu,

Dascalescu,

Constantin

et al. 2023

Medicina

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Impacts and Correlations on Corneal Biomechanics, Corneal Optical Density and Intraocular Pressure after Cataract Surgery

Lin,

Ho,

et al. 2024

Diagnostics

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The study aimed to investigate the extended effects and interrelations of corneal biomechanics, corneal optical density (COD), corneal thickness (CT), and intraocular pressure (IOP) following cataract surgery. Sixteen eyes were analyzed prospectively. The Corneal Visualization Scheimpflug Technology (Corvis ST) device assessed corneal biomechanics, while the Pentacam AxL® (Pentacam) measured COD and CT. Postoperative data were collected around six months after surgery, with a subgroup analysis of data at nine months. The Pearson correlation was used to examine the relationship between surgical-induced changes in corneal biomechanics and COD. At six months, significant postoperative differences were observed in various biomechanical indices, including uncorrected IOP (IOPuct) and biomechanics-corrected IOP (bIOP). However, many indices lost statistical significance by the nine-month mark, suggesting the reversibility of postoperative corneal changes. Postoperative COD increased at the anterior layer of the 2−6 mm annulus and incision site. The changes in COD correlated with certain biomechanical indices, including maximal (Max) deformative amplitude (DA) and stiffness parameter (SP). In conclusion, despite significant immediate postoperative changes, corneal biomechanics, COD, and IOP experienced a gradual recovery process following cataract surgery. Clinicians should maintain vigilance for any unusual changes during the short-term observation period to detect abnormalities early.

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Correlations between corneal biomechanics and specular microscopy in patient with cataract

Cited by 2 publications

References 44 publications

Particular Anatomy of the Hyperopic Eye and Potential Clinical Implications

Particular Anatomy of the Hyperopic Eye and Potential Clinical Implications

Impacts and Correlations on Corneal Biomechanics, Corneal Optical Density and Intraocular Pressure after Cataract Surgery

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