Corneal crosslinking for the treatment of infectious keratitis: a review

Feizi, Sepehr; Karimian, Farid; Esfandiari, Hamed

doi:10.1080/17469899.2021.1933440

Cited by 2 publications

(2 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A commonly employed radiation is the region A of the ultraviolet (UV-A) radiation with wavelengths between 320 and 400 nm, although the more energetic regions UV-B and UV-C have been also experimented with in some applications. As mentioned earlier, the only approved therapeutic procedure based on UV-A-induced crosslinking belongs to ophthalmology and refers to a treatment for keratoconus [13][14][15][16]. Our present study shows that the UV-A-induced crosslinking of adventitial collagen promoted by a suitable photosensitizer can lead both to an increase in strength and stiffness and to a reduction of the collagenolytic degradative effects.…”

Section: Discussionsupporting

confidence: 62%

“…It is also expected that the crosslinking process will stabilize the collagen against enzymatic degradation. The procedure was inspired by the photochemical crosslinking of the eye's corneal collagen [13][14][15][16], currently a safe primary treatment for keratoconus, an ophthalmic pathological condition of unknown mechanism that leads to severe visual impairment. While the collagen crosslinking cannot cure the condition, it is able to arrest its progression, and it has become a routine procedure in ophthalmology.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Photocrosslinking of Adventitial Collagen in the Porcine Abdominal Aorta: A Preliminary Approach to a Strategy for Prevention of Aneurysmal Rupture

Chirilă

Suzuki

2022

Designs

View full text Add to dashboard Cite

This study was aimed at generating data for designing a potential method to prevent the rupture of the abdominal aortic aneurysm (AAA). We found that the mechanical strength and stiffness of blood vessel walls was enhanced by the crosslinking of adventitial collagen through a photochemical process promoted by ultraviolet-A (UV-A) radiation. The experiments were carried out on samples isolated from 25 normal porcine aortas. The adventitial layer was separated from the other layers and exposed to UV radiation of 365-nm wavelength, in the presence of a riboflavin compound as the photosensitizer. Mechanical testing of 30 specimens, prior to and after exposure, indicated an increase in both strength (ultimate stress) and stiffness (Young’s modulus) of the adventitial specimens following irradiation. The crosslinking process also led to an enhanced resistance to experimental collagenolysis, as determined on six specimens. At this phase of conceptual design, we suggest that by applying this method to an aneurysmal dilated wall region, the stabilization of tunica adventitia may delay or prevent the rupture of the aneurysm and, with further investigation and refinement, can become a therapeutic strategy for arresting the progression of AAA.

show abstract

Section: Discussionsupporting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Photocrosslinking of Adventitial Collagen in the Porcine Abdominal Aorta: A Preliminary Approach to a Strategy for Prevention of Aneurysmal Rupture

Chirilă

Suzuki

2022

Designs

View full text Add to dashboard Cite

show abstract

A bibliometric and citation network analysis of crosslinking

Sánchez-Tena,

Pérez,

Villa-Collar

et al. 2024

European Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose: Research on crosslinking has focused mainly on trying to slow the progression of keratoconus. The objective of this bibliometric analysis is to determine the relationships between the different publications and authors. As well as to identify the different areas of research on crosslinking. Methods: Web of Science (WOS) was the database for the search of publications for the period 1972 to December 2023, using the terms: crosslinking, cross-linking, ocular, vision, visual, cornea, ectasia AND Keratoconus. The analysis of the publication was performed using the CitNetExplorer, VOSviewer and CiteSpace software. Results: 7161 publications and 59415 citation networks were found. The year with the most publications is 2021, a total of 571 (7.97%) publications and 135 citation networks. The most cited publication was “Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus” published by Wollensak et al. in 2003, with a citation index of 1780. Using the Clustering function, five groups were found that cover the main research areas in this field: keratoconus, corneal transplantation, cataracts, corneal inflammation and axial growth. Conclusion: The treatment of keratoconus continues to be the topic of interest in this area of research. However, in recent years there has been an increase in research on how crosslinking helps to slow down axial growth.

show abstract

Corneal crosslinking for the treatment of infectious keratitis: a review

Cited by 2 publications

References 87 publications

Photocrosslinking of Adventitial Collagen in the Porcine Abdominal Aorta: A Preliminary Approach to a Strategy for Prevention of Aneurysmal Rupture

Photocrosslinking of Adventitial Collagen in the Porcine Abdominal Aorta: A Preliminary Approach to a Strategy for Prevention of Aneurysmal Rupture

A bibliometric and citation network analysis of crosslinking

Contact Info

Product

Resources

About