Corneal Collagen Cross Linking (Cxl) in Treatment of Pseudophakic Bullous Keratopathy

Khan, Muhammad Saim; Basit, Imran; Ishaq, Mazhar; Shakoor, Tariq; Yaqub, Amer; Intisar, Rana

doi:10.12669/pjms.324.10138

Cited by 14 publications

(21 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…with Riboflavin and ultraviolet A (UVA) radiations is a photochemical process that was introduced by Seiler and Spoerl at the University of Dresden for the treatment of corneal ectatic disorders such as keratoconus and post LASIK ectasias [13].…”

Section: Corneal Collagen Cross Linking (Cxl)mentioning

confidence: 99%

See 1 more Smart Citation

Pseudophakic bullous keratopathy

Pricopie

Istrate

Voinea

et al. 2017

rjo

View full text Add to dashboard Cite

REVIEW 90 AbstractPseudophakic bullous keratopathy is characterized by corneal stromal edema with epithelial and subepithelial bullae due to cell loss and endothelial decompensation through trauma during cataract surgery. Patients present decreased vision, tearing, and pain caused by ruptured epithelial bullae. Cataract affects approximately 20 million people worldwide, and this complication can occur in 1 to 2% of the cataract surgeries. This study reviewed the bullous keratopathy etiopathogenesis and the clinical and surgical treatment available for this corneal disease.

show abstract

Section: Corneal Collagen Cross Linking (Cxl)mentioning

confidence: 99%

“…These highly reactive oxygen radicals then induce the crosslinking of corneal stromal collagen and strengthen the cornea [13].…”

Section: Corneal Collagen Cross Linking (Cxl)mentioning

confidence: 99%

Pseudophakic bullous keratopathy

Pricopie

Istrate

Voinea

et al. 2017

rjo

View full text Add to dashboard Cite

show abstract

“…Some limitations such as visual acuity recovery occur because of the high astigmatism and, although the cornea is the most commonly transplanted tissue in the body and corneal grafts high success rate, there is also the risk of rejection 5,10 .Corneal transplantation refers to surgical replacement of a full-thickness or lamellar portion of the host cornea with that of a donor eye. If the donor is another person, the procedure is called an allograft; use of donor tissue from the same or fellow eye is called an autograft 11 .…”

Section: Introductionmentioning

confidence: 99%

Penetrating Keratoplasty Following Superficial Keratectomy, Amniotic Membrane Patch and Bandage Soft Contact Lenses in Band and Pseudophakic Bullous Keratopathy

Samad¹,

Sirajuddin²,

Eka³

2021

View full text Add to dashboard Cite

Introduction: Band keratopathy is usually associated with chronic ocular inflammatory conditions. Recent use of combination treatments such as chelation,excimer laser,and amniotic membrane transplantation in band keratopathy management. Bullous keratopathy (BK) is a main complication of cataract surgery.The purpose of treatment are to reduce pain and improve vision when possible. Treatment depending on the severity of symptoms,cause of BK and potential for visual improvement. BK is a leading indication for keratoplasty and improvement of vision is possible only with keratoplasty. Objective: To report a case of a 64-year-old man with penetrating keratoplasty (PK) following superficial keratectomy (SK), amniotic membrane patch (AMP) and bandage soft contact lenses (BSCL) in band and pseudophakic bullous keratopathy. Case presentation: A 64-year-old man with band and pseudophakic bullous keratopathyreported with reduced vision in both the eyes (1/300 and 6/48 BCVA in the right and left eye, respectively) for past few years.SK, AMP and BSCLwas performed for ocular surface reconstruction in his right eye. One month later, he underwent a PK and3 months following surgery, the corneal graft remained transparent. Six months after the surgery, BCVA of the right eye was 6/30 with S - 3,00 refractive correction. Conclusion: Patients with band and pseudophakic bullous keratopathy can achieve visual outcomes and realise a significant improvement in corneal transparency by undergoing SK, AMP, BSCL and PK.

show abstract

“…Об эффективном применении ККР в лечении заболеваний эндотелия имеются данные разных групп авторов из разных стран [18,19], но наряду с положительными результатами имеются и отрицательные [20,21].…”

Section: Introductionunclassified

Еvaluate the Effectiveness of Accelerated Collagen Crosslinking in the Treatment of Corneal Endothelial Decompensation

et al. 2020

View full text Add to dashboard Cite

The article discusses the effectiveness of accelerated collagen crosslinking in the treatment of patients with corneal diseases, a common basic pathogenetic link of which is endothelial corneal decompensation. This method was used to treat patients with bullous keratopathy and endothelial dystrophy of Fuchs’ cornea with a long postoperative follow-up. In connection with the controversial results of researchers, reflecting the positive dynamics of the postoperative period, the question of the expediency of accelerated collagen cross-linking in patients with this pathology as a monotherapy is discussed.The study included 25 patients (26 eyes) with mean age 69.10 ± 10.61 years (40 to 82 years). There was Fuchs corneal endothelial dystrophy in 16 patients (17 eyes), in 9 patients (10 eyes) — stage II, in 7 patients (7 eyes) — stage III. Bullous keratopathy was present in 9 patients (9 eyes). All patients underwent treatment according to the method of accelerated collagen corneal crosslinking. In patients with bullous keratopathy (9 eyes), the data on the central thickness of the cornea and the maximum corrected visual acuity did not differ from the initial data at any of the postoperative visits, and did not differ from each other (p > 0.83). On the contrary, in some patients the dystrophic process progressed in the form of the appearance of fibrotic changes in the stroma of the cornea. Corneal transplantation was recommended to all patients under observation after treatment at different periods of observation. In patients with Fuchs endothelial dystrophy, a significant difference in the maximum corrected visual acuity from the initial data was observed only 6 months after surgery.The expediency of accelerated collagen cross-linking in the treatment of patients with corneal diseases accompanied by endothelial decompensation as monotherapy is very doubtful. The study of combined surgical methods for treating this complex corneal pathology using cross-linking as an auxiliary method seems promising.

show abstract

Corneal Collagen Cross Linking (Cxl) in Treatment of Pseudophakic Bullous Keratopathy

Cited by 14 publications

References 21 publications

Pseudophakic bullous keratopathy

Pseudophakic bullous keratopathy

Penetrating Keratoplasty Following Superficial Keratectomy, Amniotic Membrane Patch and Bandage Soft Contact Lenses in Band and Pseudophakic Bullous Keratopathy

Еvaluate the Effectiveness of Accelerated Collagen Crosslinking in the Treatment of Corneal Endothelial Decompensation

Contact Info

Product

Resources

About