Corneal Biomechanics in Non-infectious Uveitis Measured by Corvis ST: A Pilot Study

Borrego-Sanz, Lara; Morales-Fernández, Laura; Baldomero, Federico Sáenz-Francés San; Valle, David Díaz; Cour, E. Pato; Fernández, Rosalía Méndez; García‐Feijoó, Julián; Rodríguez, L. Rodríguez

doi:10.1080/09273948.2022.2108462

Cited by 2 publications

(2 citation statements)

References 49 publications

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“…Corvis ST parameters have been shown to reflect stiffer corneas in open-angle glaucoma, even when the effect of age, thickness, and IOP were accounted for [30]. Corvis ST has also been applied to keratoconus [31,32] and uveitis [33], where differences compared to healthy eyes have been appreciated.…”

Section: Corvis Stmentioning

confidence: 99%

New forays into measurement of ocular biomechanics

Hammelef,

Rapuano,

Benedetto

et al. 2024

Current Opinion in Ophthalmology

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Purpose of review The field of corneal biomechanics has rapidly progressed in recent years, reflecting technological advances and an increased understanding of the clinical significance of measuring these properties. This review will evaluate in-vivo biomechanical properties obtained by current technologies and compare them regarding their relevance to established biomechanical properties obtained by gold-standard ex-vivo techniques normally conducted on elastic materials. Recent findings Several new technologies have appeared in recent years, including vibrational optical coherence tomography (VOCT) and the corneal indentation device (CID). These techniques provide promising new opportunities for minimally invasive and accurate measurements of corneal viscoelastic properties. Summary Alterations in corneal biomechanics are known to occur in several corneal degenerative diseases and after refractive surgical procedures. The measurement of corneal biomechanical properties has the capability to diagnose early disease and monitor corneal disease progression. Several new technologies have emerged in recent years, allowing for more accurate and less invasive measurements of corneal biomechanical properties, most notably the elastic modulus.

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Section: Corvis Stmentioning

confidence: 99%

New forays into measurement of ocular biomechanics

Hammelef,

Rapuano,

Benedetto

et al. 2024

Current Opinion in Ophthalmology

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“…Utilizing noncontact measuring instruments could provide more accurate estimates of IOP in patients active and acute ACI [55]. However, such equipment has not been comprehensively tested in patients with ACI, and their use requires further investigation [56].…”

Section: Plos Onementioning

confidence: 99%

Quantitative changes in the corneal endothelium and central corneal thickness during anterior chamber inflammation: A systematic review and meta-analysis

Mejía-Salgado,

Muñoz-Vargas,

Cifuentes-González

et al. 2024

PLoS ONE

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Purpose To establish the effects of anterior chamber inflammation (ACI) on the corneal endothelium parameters and central corneal thickness (CCT). Methods We conducted a comprehensive literature review using medical databases (PubMed, EMBASE, VHL, and medRxiv) on March 8, 2023, for studies that included patients with ACI who had undergone specular microscopy or pachymetry. Case series with >10 patients, cross-sectional, case-control, and cohort studies were included. The risk of bias was assessed using CLARITY tools and validated scales such as those by Hassan Murad et al. and Hoy et al. A narrative synthesis and a quantitative standardized mean difference meta-analysis, I2 heterogeneity assessment, and publication bias tests were conducted. The study was registered in PROSPERO (CRD42023420148) and approved by the Universidad del Rosario ethical committee (DVO005 2277- CV1712). Results Thirty-four studies, encompassing 1,388 eyes with ACI, were included. Compared with healthy controls, overall, ACI eyes show significant mean differences in endothelial parameters (endothelial cell density (ECD), coefficient of variation (CV), and hexagonality (HEX)) (P < 0.05). In the subgroup analysis compared with healthy controls, both active and chronic-recurrent ACI demonstrated a reduced ECD. An increased CV was observed in active, inactive, and chronic-recurrent ACI. Lower HEX was evident in inactive, acute, and chronic-recurrent ACI, while both active and acute ACI exhibited high CCT. Conclusion ACI leads to significant alterations in endothelial parameters and CCT. The primary contributors to these changes are increased IOP, uveitis duration, and intraocular surgeries. Further studies are needed to explore the impact of ACI etiology on the endothelium, potential biases in IOP measurements during acute ACI episodes, and the potential necessity for monitoring the endothelial parameters and CCT in patients with chronic ACI.

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Corneal Biomechanics in Non-infectious Uveitis Measured by Corvis ST: A Pilot Study

Cited by 2 publications

References 49 publications

New forays into measurement of ocular biomechanics

New forays into measurement of ocular biomechanics

Quantitative changes in the corneal endothelium and central corneal thickness during anterior chamber inflammation: A systematic review and meta-analysis

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