Corneal Biomechanical Comparison of Pseudoexfoliation Syndrome, Pseudoexfoliative Glaucoma and Healthy Subjects

Yazgan, Serpil; Çelik, Uğur; Alagöz, Neşe; Taş, Mehmet

doi:10.3109/02713683.2014.930157

Cited by 27 publications

(19 citation statements)

References 31 publications

(38 reference statements)

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“…Using the Ocular Response Analyzer (ORA) (Depew, NY, USA), Yazgan et al, found decreased corneal hysteresis (CH) and corneal resistance factor (CRF) in PEX and PEXG eyes compared to normal control eyes. [77] In a retrospective review, Ayala found reduced CH in PEXG eyes compared to POAG eyes. [78] This may also be a result of ECM and hydration alterations related to changes in keratocytes and disturbed endothelial counts, and could potentially indicate an alteration in the entire corneoscleral shell.…”

Section: Discussionmentioning

confidence: 99%

Corneal alterations associated with pseudoexfoliation syndrome and glaucoma: A literature review

Palko

Sheybani

2017

J Ophthalmic Vis Res

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A systematic literature review was performed evaluating articles examining the effects of pseudoexfoliation syndrome (PEX) and glaucoma (PEXG) on the cornea with a focus on the corneal endothelium. We searched for articles relevant to pseudoexfoliation syndrome, pseudoexfoliation glaucoma and corneal endothelial cell counts using Pubmed, Google Scholar Database, Web of Science and Cochrane Library databases published prior to September of 2016. We then screened the references of these retrieved papers and performed a Web of Science cited reference search. Corneal characteristics analyzed included central corneal thickness (CCT), corneal nerve density, endothelial cell density (ECD), polymegathism, and pleomorphism. These parameters were compared in the following populations: control, PEX, PEXG, and primary open angle glaucoma (POAG). Over 30 observational studies were reviewed. Most studies showed a statistically significant lower ECD in PEX and PEXG populations compared to controls. Overall, PEX eyes had a non-statistically significant trend of lower ECDs compared to PEXG eyes. No consistent trends were found when analyzing differences in CCT amongst control, PEX and PEXG groups. For the few studies that looked at corneal nerve characteristics, the control groups were found to have statistically significantly greater nerve densities than PEX eyes, which had significantly greater densities than PEXG eyes. ECD and corneal nerve densities may be potential metrics for risk-stratifying patients with PEX and PEXG. Our literature review provided further evidence of the significant negative influence PEX has on the cornea, worsening as patients convert to PEXG.

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Section: Discussionmentioning

confidence: 99%

Corneal alterations associated with pseudoexfoliation syndrome and glaucoma: A literature review

Palko

Sheybani

2017

J Ophthalmic Vis Res

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“…Similar to some reports from Europe [25, 28], we found no statistically significant difference of CCT between PXG and POAG subjects. Some studies from other regions have shown PXG eyes to have thinner CCT compared to POAG and normal eyes [19, 29, 30], while others found thicker CCT in PXG compared to POAG eyes. Although our PXG patients had older mean age (which was associated with thinner CCT) and higher IOP, these were not found to affect the overall CCT on regression analysis.…”

Section: Discussionmentioning

confidence: 99%

Central corneal thickness in newly diagnosed glaucoma patients in South West Ethiopia: a cross-sectional study

Tolesa

Gessesse

2016

BMC Ophthalmol

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BackgroundReports of central corneal thickness (CCT) among glaucoma patients, particularly for pseudoexfoliative glaucoma (PXG) and Primary Angle Closure Glaucoma (PACG) are scarce in the Sub-Saharan African (SSA) population. The aim of this study is to evaluate CCT in black patients with newly diagnosed glaucoma and ocular hypertension (OHT) in South West Ethiopia.MethodsThis was a prospective study undertaken with an ultrasonic pachymeter from June 2014 to February 2015 in Jimma University Specialized Hospital. Patients aged 18 years and older newly diagnosed with glaucoma or OHT were included.ResultsA total of 162 eyes of 162 subjects were included. Hundred and fifty five subjects were glaucomatous: (67 PXG, 42 Primary Open Angle Glaucoma (POAG), 28 PACG, 14 Normal Tension Glaucoma (NTG), 5 Juvenile Open Angle Glaucoma (JOAG) and 6 (OHT). The mean age was 59.3 ± 12.8 years.For the whole sample, CCT was 518.67 (±39.97) μm. OHT group had significantly greater CCT (576.33 ± 49.32 μm) than the glaucomatous groups (p = 0.004). POAG (506.69 ± 35.08 μm) and NTG (510.79 ± 44.37 μm) groups had thinner CCT than PXG (520.48 ± 38.95 μm), PACG (524.00 ± 37.16 μm), and JOAG (518.00 ± 30.82 μm) groups, but this was not statistically significant (p = 0. 296). There was a statistically significant decline of CCT with advanced age (P = 0.02). There wasn’t significant difference of average CCT between the ethnic groups (P = 0.3) and gender (P = 0.064).ConclusionThe mean CCT of Ethiopian glaucoma patients is thinner than Caucasians and similar to those reported from previous studies in Sub Saharan Africa. OHT patients had thicker CCT; there was no statistically significant difference observed in average CCT amongst glaucoma subtypes.

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“…20,21 Abnormalities of stromal keratocytes and altered stromal hydration because of functional impairment in the endothelium (PES corneal endotheliopathy) may be the cause of increased COD in the central layer of the cornea.…”

Section: Discussionmentioning

confidence: 99%

Effect of Pseudoexfoliation on Corneal Transparency

Cankaya

Tekin²,

İnanç³

2016

Cornea

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Corneal Biomechanical Comparison of Pseudoexfoliation Syndrome, Pseudoexfoliative Glaucoma and Healthy Subjects

Abstract: In this study, the corneal biomechanical features of subjects with PEX were found to be changed as compared to healthy controls. In these patients; CH, CRF and CCT were decreased which was more obvious in patients with PEXG in comparison to PEX patients.

Cited by 27 publications

References 31 publications

Corneal alterations associated with pseudoexfoliation syndrome and glaucoma: A literature review

Corneal alterations associated with pseudoexfoliation syndrome and glaucoma: A literature review

Central corneal thickness in newly diagnosed glaucoma patients in South West Ethiopia: a cross-sectional study

Effect of Pseudoexfoliation on Corneal Transparency

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