Cornea Biomechanical Characteristics and Their Correlates with Refractive Error in Singaporean Children

Lim, Laurence Shen; Gazzard, Gus; Chan, Yiong‐Huak; Fong, Allan; Kotecha, Aachal; Sim, Ee-Ling; Tan, Donald; Tong, Louis; Saw, Seang‐Mei

doi:10.1167/iovs.07-1670

Cited by 104 publications

(129 citation statements)

References 40 publications

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“…[1][2][3][4][5][6][7][8][9][10][11]27 Thus, as IOP increases, CH values systematically decrease, particularly when IOP values exceed the statistically normal range. 27 Whether this phenomenon is physiological, an artifact of testing, or a combination of the two is debated, but a physiological relationship between CH and IOP appears reasonable if one considers that increasing IOP is associated with stiffening of the ocular coats (sclera/ cornea) 23,24 and stiffer tissues have reduced capability to dampen further increases of IOP-related stress.…”

Section: Discussionmentioning

confidence: 99%

“…Recent research has provided evidence that corneal biomechanical properties may have a meaningful influence not only on intraocular pressure (IOP) measurements [1][2][3][4][5][6][7][8][9][10][11] but also on the ocular effects of IOP. [1][2][3][12][13][14][15][16][17][18][19][20][21][22] Central corneal thickness (CCT) has received the most attention in this regard, spurred by findings from the Ocular Hypertension Treatment Study (OHTS) in which CCT was the strongest independent predictor of conversion from ocular hypertension (OH) to primary open-angle glaucoma (POAG).…”

Section: Introductionmentioning

confidence: 99%

“…These findings agree with many other reports and support accounting for these factors, particularly CCT and IOP, when interpreting CH. [1][2][3][4][5][6][7][8][9][10][11][12]14 This study was therefore designed to examine whether the clinical utility of CH might be enhanced by adjusting CH for the effects of CCT and IOP. To accomplish this goal, we employed a three-step approach.…”

Section: Introductionmentioning

confidence: 99%

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Combining corneal hysteresis with central corneal thickness and intraocular pressure for glaucoma risk assessment

Pensyl

Sullivan-Mee

Torres-Monte

et al. 2012

Eye

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Purpose To determine whether adjusting corneal hysteresis (CH) values for central corneal thickness (CCT) and intraocular pressure (IOP) improves its capability to differentiate primary open-angle glaucoma (POAG) from ocular hypertension (OH). Methods This prospective, observational, cross-sectional study included 169 eyes of 169 subjects with a diagnosis of POAG (n ¼ 81) or OH (n ¼ 88). We utilized the Ocular Response Analyzer (ORA), Pascal Dynamic Contour Tonometer (DCT), Goldmann applanation tonometer (GAT), and ORA ultrasound pachymeter to obtain CH, IOP, and CCT values. Correlational, regression, and t-test analyses were conducted before and after the sample was divided into low, intermediate, and thick CCT subgroups. Results In the full sample, CH and CCT were moderately correlated (r ¼ 0.44, Po0.001). Although both were related to diagnosis in univariate regression analysis, only CH was independently related to glaucoma diagnosis in multivariate analysis. After the sample was divided into CCT tertiles, CH was significantly lower in POAG vs OH eyes within all three CCT subgroups, and CH was the only multivariate variable that differentiated POAG from OH in each CCT subgroup. Moreover, the relationship between CH and diagnosis was more robust within the CCT subgroups compared with the full sample, suggesting that integrating CCT into CH interpretation is beneficial. Adjusting CH for IOP did not aid diagnostic precision in this study. ConclusionOur findings suggest that combining CH and CCT for glaucoma risk assessment improves diagnostic capability compared to using either factor alone. Conversely, adjusting CH for IOP provided no clear clinical benefit in this study.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Combining corneal hysteresis with central corneal thickness and intraocular pressure for glaucoma risk assessment

Pensyl

Sullivan-Mee

Torres-Monte

et al. 2012

Eye

View full text Add to dashboard Cite

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“…These factors may influence the correlation between myopia, IOP and biomechanical properties of cornea. 16,17 The other limitation is that the investigative groups are not age or gender matched which may influence the results. However, no significant differences were found between the females and males in each group.…”

Section: Discussionmentioning

confidence: 99%

A study on association between intraocular pressure and myopia

et al. 2016

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“…40,41 CH is correlated with CCT, and seems not to be associated with refractive error or axial length. 42,43 CH as measured by the ORA is described in greater detail elsewhere. 40,41,44 For this study, four measurements were obtained for each eye and the average was considered as the final value for analysis.…”

Section: Methodsmentioning

confidence: 99%

Factors associated with topographic changes of the optic nerve head induced by acute intraocular pressure reduction in glaucoma patients

Prata

Lima

Moraes

et al. 2010

Eye

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Purpose To investigate factors associated with changes in optic nerve head (ONH) topography after acute intraocular pressure (IOP) reduction in patients with primary open-angle glaucoma (POAG). Methods Untreated POAG patients (IOP 421 mm Hg) were prospectively enrolled. Systemic and ocular information were collected, including central corneal thickness (CCT) and corneal hysteresis (CH). All patients underwent confocal scanning laser ophthalmoscopy and tonometry (Goldmann) before and 1 h after pharmacological IOP reduction. The mean of three measurements was considered for analysis. Changes in each ONH topographic parameter were assessed (one eye was randomly selected), and those that changed significantly were correlated with patient's systemic and ocular characteristics. Results A total of 42 patients were included (mean age, 66.7 ± 11.8 years). After a mean IOP reduction of 47.3±11.9%, significant changes were observed in cup area and volume, and in rim area and volume (Po0.01), but not in mean cup depth (P ¼ 0.80). Multiple regression analysis (controlling for baseline IOP and magnitude of IOP reduction) showed that CH (r 2 ¼ 0.17, Po0.01) and diabetes diagnosis (r 2 X0.21, Po0.01) were negatively correlated with the magnitude of changes in ONH parameters, whereas the cup-to-disc ratio was positively correlated (r 2 ¼ 0.30, Po0.01). Age, race, disc area, and CCT were not significant (PX0.12). Including all significant factors in a multivariable model, only the presence of diabetes remained significantly associated with all ONH parameters evaluated (Po0.01). Conclusions Different systemic and ocular factors, such as diabetes, CH, and the relative size of the cup, seem to be associated with the magnitude of changes in ONH topography after acute IOP reduction in POAG patients. These associations partially explain the ONH changes observed in these patients and suggest that other factors are possibly implicated in an individual susceptibility to IOP.

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Cornea Biomechanical Characteristics and Their Correlates with Refractive Error in Singaporean Children

Abstract: The CH and CRF values in our study on Singaporean children are slightly higher than in adult studies. CH and CRF are not associated with refractive error or axial length. Flatter corneas are associated with lower CH and CRF readings.

Cited by 104 publications

References 40 publications

Combining corneal hysteresis with central corneal thickness and intraocular pressure for glaucoma risk assessment

Combining corneal hysteresis with central corneal thickness and intraocular pressure for glaucoma risk assessment

A study on association between intraocular pressure and myopia

Factors associated with topographic changes of the optic nerve head induced by acute intraocular pressure reduction in glaucoma patients

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