Cornea and Sclera

Yanoff, Myron; Sassani, Joseph W.

doi:10.1016/b978-0-323-04232-1.50013-x

Cited by 3 publications

(2 citation statements)

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“…We classified corneal lesions according to Parson and Myronn Yanoff as follows. 17,18 Classification:…”

Section: Methodsmentioning

confidence: 99%

Clinicopathological study of recipients’ corneal tissue excised during penetrating keratoplasty. Best out of waste!

Gupta¹,

Hake²,

Kumbhalkar³

et al. 2020

ACHR

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Introduction: Corneal buttons removed during penetrating keratoplasties (PK) from recipients' which were routinely discarded were studied with aim to analyze the common indications of PK and changing pattern of corneal diseases in developing countries like India. Materials and Methods: This is an observational case series carried out in tertiary care hospital of central India from October 2012 to October 2014. Histopathology of 156 corneal tissues was done of which 75 were recipients' corneal tissues removed during PK and 81 were residual adjacent donors' corneal tissues left out after corneal button was removed for transplant. Results: The most common indication of PK in our study was corneal ulcer (n=37, 49.33%), followed by infectious keratitis (n=22, 29.33%) which included ulcers in various stages of healing and complications associated with ulcer like adherent leucoma. Amongst infectious keratitis, 17 were (77.27%) of bacterial keratitis and 5 (22.73%) of fungal keratitis. Followed by bullous keratopathy 8(10.66%), 3(4%) of graft rejection and one each (1.33%) of Fuchs' dystrophy and chronic actinic keratopathy. Of 81 donor's corneal tissues, 75 were the residual corneal tissues from corneo-conjunctival junction which were transplanted within stipulated time. Only one case showed changes of chronic actinic keratopathy, rest showed normal histology. 6 corneas which were not transplanted within stipulated time showed epithelial denudation and stromal degeneration with loss of keratocytes. Conclusion: Histopathology gives additional insight to clinical diagnosis. Specific diagnosis can be commented in corneal opacities and infectious keratitis.

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“…We classified corneal lesions according to Parson and Myronn Yanoff as follows. 17,18 Classification:…”

Section: Methodsmentioning

confidence: 99%

Clinicopathological study of recipients’ corneal tissue excised during penetrating keratoplasty. Best out of waste!

Gupta¹,

Hake²,

Kumbhalkar³

et al. 2020

ACHR

View full text Add to dashboard Cite

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“…Nodular granulomatous episcleritis (NGE) has been defined as a form of primary (idiopathic) episcleritis and is presumed to reflect an immune‐mediated disease process. Primary episcleritis has been classified as diffuse (simple) or nodular, with the latter being the less frequently seen clinical form . Lesions most commonly arise at the level of the limbus, with variable extension into the cornea; however, similar inflammatory foci can arise in the conjunctiva elsewhere, and less commonly in the orbit .…”

Section: Introductionmentioning

confidence: 92%

Clinical and pathological findings in three dogs with a corneocentric presentation of nodular granulomatous episcleritis

Hamzianpour¹,

Heinrich²,

Jones³

et al. 2019

Veterinary Ophthalmology

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Purpose To describe the clinical signs, management, histopathologic findings, and outcome of three dogs with a corneocentric presentation of nodular granulomatous episcleritis (NGE). Methods Three dogs of varying breeds were presented for a unilateral, nonpainful, and infiltrative corneal lesion in the dorsal aspect of the eye. Clinical response to symptomatic topical treatment directed at a presumed inflammatory or immune‐mediated cause was poor. Due to this, and concerns of neoplasia, ultrasonography (n = 1), incisional biopsy (n = 2), and/or enucleation (n = 2) were performed. Results The inflammatory infiltrate observed on histopathology was identical to that seen in nodular granulomatous episcleritis in all three cases. However, atypically the inflammation was confined to the cornea and limbus, without episcleral or conjunctival involvement. Inflammation of the cornea was full thickness to Descemet's membrane. Following enucleation (n = 2), there were no postoperative complications, and no reported ophthalmic disease in the remaining eye. Currently, the single non‐enucleated case remains controlled with systemic and topical immunosuppression. Conclusion To the best of the authors’ knowledge, this is the first report of an NGE condition purely affecting the full thickness of the cornea, without episcleral or conjunctival involvement. The authors propose this to represent an atypical corneocentric variant of NGE. This clinical presentation can resemble neoplasia; incisional biopsy is recommended for a definitive diagnosis. Further research into the optimal treatment strategies for this variant of NGE is required.

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From post-war reconstruction to the 21st century – Ophthalmic pathology in Freiburg 1945- 2015: Review of 39,256 surgical specimens from various topographical regions collected over 71 years at a large German tertiary eye care centre

Glegola,

Schulz,

Nüßle

et al. 2024

Preprint

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Background Ophthalmic pathology at the Eye Center at Medical Center, University of Freiburg, Germany, looks back on a tradition of more than 150 years. Surgical specimens and associated histological diagnoses have been archived since 1945. This study is the first of its size to include 39,256 specimens examined in a single ophthalmic pathology laboratory over 71 years. Methods We retrospectively studied ophthalmic pathology reports and clinical records of histological specimens archived between 1945 and 2015 and compared our results with 22 studies from the literature. Samples were grouped by localisation and histopathological diagnoses assigned to various categories. Both were coded and entered into a database together with the year of surgery, patient sex and age at excision. Results The patients’ age at surgery was documented in 38,845 cases (99%), of which 19,601 were female (50.5%) and 19,244 were male patients (49.5%). The bimodal frequency distribution of specimens by patient age has a similar shape to that recorded 1941–1995 for Atlanta, USA and 1959–2021 for the Swedish population. Most specimens originated from the eyelid (50%), followed by cornea (16%), conjunctiva (14%), eyeball (9.1%), temporal artery (3.9%) and other locations (6.7%) comprising 16 less frequent topographies. The proportion of eyelid (corneal, conjunctival) lesions significantly increased 4-fold (5-fold, 2-fold) during our study period (each p < .001); that of enucleations and temporal artery biopsies decreased significantly 38- and 3.6-fold (each p < .001). Concurrently, the numbers of eyelid, corneal, conjunctival and temporal artery specimens have significantly grown (each p < .001). Annual sample numbers increased significantly across the various medical directors’ tenures (1945–1967: median = 78; 1968–1987: median = 454; 1988–2002: median = 670; 2003–2015: median = 1,445) (p < .001). Conclusions Historical events, general population developments and new surgical techniques and treatment options caused changes in the occurrence of various ocular and periocular specimens. Our study data contribute to providing an overall picture of the nature and relative frequency of ocular conditions leading to surgical excision of specimens with subsequent histopathological examination. A continuous sharp increase in case numbers since 1987 clearly exceeds the demographic trend emphasising the ever-growing importance of the sub-speciality of ophthalmic pathology.

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Cornea and Sclera

Cited by 3 publications

References 482 publications

Clinicopathological study of recipients’ corneal tissue excised during penetrating keratoplasty. Best out of waste!

Clinicopathological study of recipients’ corneal tissue excised during penetrating keratoplasty. Best out of waste!

Clinical and pathological findings in three dogs with a corneocentric presentation of nodular granulomatous episcleritis

From post-war reconstruction to the 21st century – Ophthalmic pathology in Freiburg 1945- 2015: Review of 39,256 surgical specimens from various topographical regions collected over 71 years at a large German tertiary eye care centre

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