Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells

Gambari, Roberto; Borgatti, Monica; Lampronti, Ilaria; Fabbri, Enrica; Brognara, Eleonora; Bianchi, Nicoletta; Piccagli, Laura; Yuen, Marcus Chun Wah; Kan, Chi Wai; Hau, Desmond Kwok-Po; Fong, Wang‐Fun; Wong, Wai Yeung; Wong, Raymond Pui On; Chui, Chung‐Hin

doi:10.1016/j.intimp.2012.04.010

Cited by 57 publications

(39 citation statements)

References 58 publications

(103 reference statements)

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“…Therefore, we performed a quantitative measurement using the Bio-plex technology [8, 9] of multiple cytokines released by both keratynocytes and lung cells after vapors exposure. The results concerning the released cytokines/chemokines displaying concentrations ≥ 5 pg/ml in both HaCaT and A549 cells were taken in consideration in order to mimimize the background, and are reported in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Comparative effects between electronic and cigarette smoke in human keratinocytes and epithelial lung cells

Cervellati

Muresan

Sticozzi

et al. 2014

Toxicology in Vitro

191

147

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Background Information about the harmful effects of vaping is sparse and inconsistent, therefore, since the use of electronic cigarettes (e-CIGs) has become increasingly popular as a tool to limit tobacco smoking, it is urgent to establish the safety or the toxicity of the liquid vaporized by the atomizer of the commercial e-CIGs. Methods Skin (HaCaT) and lung (A549) cells, the main targets of cigarette smoke, were exposed to e-CIG vapor (e-CIG Mini Touch T-Fumo T-TEX) and cigarette smoke (UK research cigarette) in a smoke chamber in vitro. The cytotoxic effect of the exposure was analyzed in both cell types by ultrastructural morphology, Trypan Blue exclusion test and LDH assay. In addition, pro-inflammatory cytokines were measured in culture medium by the Bio-Plex cytokine assay kit. Results The cytotoxic components of e-CIG were restrained to the flavoring compound and, to a lesser extent, to nicotine and their effects were comparable to that of cigarette smoke. Humectants alone exhibited no cytotoxicity but induced the release of cytokines and pro-inflammatory mediators, mainly in keratinocytes. Conclusions Based on our results, we can state that e-CIG vapors exposure is not completely harmless, although far less toxic than CS. In fact, besides the deleterious effect of flavor and nicotine, even the humectants alone are able to evocate some adverse cellular events, such as enhanced cytokines release. This study will hopefully promote the development of truly innocuous e-CIGs to help people quit smoking.

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Section: Resultsmentioning

confidence: 99%

Comparative effects between electronic and cigarette smoke in human keratinocytes and epithelial lung cells

Cervellati

Muresan

Sticozzi

et al. 2014

Toxicology in Vitro

191

147

View full text Add to dashboard Cite

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“…Several reports have indicated that various naturally occurring compounds may play partial roles in the prevention of human pathologies [50,51]. These studies have demonstrated that bioactive compounds have anti-inflammatory effects against acute and chronic inflammation [41,52,53].…”

Section: Discussionmentioning

confidence: 99%

Allyl methyl disulfide inhibits IL-8 and IP-10 secretion in intestinal epithelial cells via the NF-кB signaling pathway

Zhang

Wang

Zhang

et al. 2015

International Immunopharmacology

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“…ROS/Akt and RIP1/NF-jB signaling pathways were found to be the chief players in inducing apoptotic cell death in hepatic cancer cell lines (Gong and Li 2011). Gambari et al (2012) reported that Corilagin found in Phyllanthus urinaria and some other plant species prevents NF-jB/DNA interactions and thus modulates expression of IL-8 gene cystic fibrosis IB3-1 cells treated with TNF-a. The apoptosis It effectively downregulated nuclear factor NF-jB DNA binding activity and suppressed the proliferation of SW620 and HCT116 cancer cells.…”

Section: Ht-29mentioning

confidence: 99%

Phytoconstituents as apoptosis inducing agents: strategy to combat cancer

et al. 2015

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Advancement in the field of cancer molecular biology has aided researchers to develop various new chemopreventive agents which can target cancer cells exclusively. Cancer chemopreventive agents have proficiency to inhibit, reverse and delay process of carcinogenesis during its early and later course. Chemopreventive agents can act as antioxidative, antimutagenic/antigenotoxic, anti-inflammatory agents or via aiming various molecular targets in a cell to induce cell death. Apoptosis is a kind of cell death which shows various cellular morphological alterations such as cell shrinkage, blebbing of membrane, chromatin condensation, DNA fragmentation, formation of apoptotic bodies etc. Nowadays, apoptosis is being one of the new approaches for the identification and development of novel anticancer therapies. For centuries, plants are known to play part in daily routine from providing food to management of human health. In the last two decades, diverse phytochemicals and various botanical formulations have been characterized as agents that possess potential to execute cancer cells via inducing apoptosis. Data obtained from the research carried out globally pointed out that natural products are the potential candidates which have capability to combat cancer. In the present review, we surveyed literature on natural products which throws light on the mechanism through which these phytochemicals induce apoptosis in cancer cells.

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Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells

Cited by 57 publications

References 58 publications

Comparative effects between electronic and cigarette smoke in human keratinocytes and epithelial lung cells

Comparative effects between electronic and cigarette smoke in human keratinocytes and epithelial lung cells

Allyl methyl disulfide inhibits IL-8 and IP-10 secretion in intestinal epithelial cells via the NF-кB signaling pathway

Phytoconstituents as apoptosis inducing agents: strategy to combat cancer

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