Core@shell nanomaterials: gold-coated magnetic oxide nanoparticles

Wang, Lingyan; Park, Hye Young; Lim, Stephanie I.; Schadt, Mark; Mott, Derrick; Luo, Jin; Wang, Xin; Zhong, Chuan Jian

doi:10.1039/b719096d

Cited by 192 publications

(147 citation statements)

References 85 publications

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“…The development of multifunctional nanomaterials combining diagnostic and therapeutic purpose has recently attracted intensive interests [1][2][3][4][5][6]. Semiconductor nanocrystals known as quantum dots (QDs) are particularly appealing for bioimaging and labeling probes due to their unique optical properties, including broad absorption with narrow photoluminescence (PL) spectra, high quantum yield, low photobleaching, and resistance to chemical degradation [2][3][4][5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

In-situ immobilization of quantum dots in polysaccharide-based nanogels for integration of optical pH-sensing, tumor cell imaging, and drug delivery

et al. 2010

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Section: Introductionmentioning

confidence: 99%

In-situ immobilization of quantum dots in polysaccharide-based nanogels for integration of optical pH-sensing, tumor cell imaging, and drug delivery

et al. 2010

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“…The direct coating of Au onto magnetic NPs severely decreased the saturation magnetizationof the magnetic core by 78% or more. [20,21]. In our method, PVP as a coupling agent, not noly prevented the magnetic NPs form large-sized aggregated precipitates in solutions, but also decreased the effect of Au coating on the magnetic properties of Fe 3 O 4 @Au nanocomposites.…”

Section: Resultsmentioning

confidence: 87%

A Facile and Green Synthetic Route for Preparation of Heterostructure Fe₃O₄@Au Nanocomposites

et al. 2016

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Abstract. Magnetic nanoparticles offer many exciting opportunities in biology and biomedicine, such as magnetic resonance imaging, magnetic hyperthermia therapy, biomedical diagnosis. The synthesis of multifunctional magnetic nanocomposites that possess watersolubility, magnetic properties and optical stability by a green method at room temperature in aqueous phase is still an unmet need. Here, we developed a simple and green method for preparing Fe3O4@Au integrated the super-paramagnetic and optical properties by seedmediated growth at mild condition in aqueous phase. The amphiphilic, non-ionic and nontoxic polymer poly(vinylpyrrolidone) (PVP) was used as a coupling agent for synthesis of Fe3O4@Au nanocomposites, which avoided the direct connection of Au and Fe3O4, and improved the saturation magnetization values of Fe3O4@Au to 40 emu/g at room temperature. We anticipate that the multifunctional Fe3O4@Au nanocomposites with high magnetic and good optical properties will provide a platform for potential diagnostic and therapeutic biomedical applications.

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“…Many recent studies report on the synthesis and MRI potential of Au-coated iron oxide nanoparticles 11 and Au/Fe bimetallic and alloy nanoparticles. 12−16 Both solutions lead to superparamagnetic nanoparticles with contrast agent capability that in addition present an exposed, inert, noble metal surface.…”

Section: ■ Introductionmentioning

confidence: 99%

Superparamagnetic Nanoparticles as High Efficiency Magnetic Resonance Imaging T₂ Contrast Agent

et al. 2016

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Nanoparticle-based magnetic resonance imaging T 2 negative agents are of great interest, and much effort is devoted to increasing cellloading capability while maintaining low cytotoxicity. Herein, two classes of mixed-ligand protected magnetic-responsive, bimetallic gold/iron nanoparticles (Au/Fe NPs) synthesized by a two-step method are presented. Their structure, surface composition, and magnetic properties are characterized. The two classes of sulfonated Au/Fe NPs, with an average diameter of 4 nm, have an average atomic ratio of Au to Fe equal to 7 or 8, which enables the Au/Fe NPs to be superparamagnetic with a blocking temperature of 56 K and 96 K. Furthermore, preliminary cellular studies reveal that both Au/Fe NPs show very limited toxicity. MRI phantom experiments show that r 2 /r 1 ratio of Au/Fe NPs is as high as 670, leading to a 66% reduction in T 2 relaxation time. These nanoparticles provide great versatility and potential for nanoparticle-based diagnostics and therapeutic applications and as imaging contrast agents.

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Core@shell nanomaterials: gold-coated magnetic oxide nanoparticles

Cited by 192 publications

References 85 publications

In-situ immobilization of quantum dots in polysaccharide-based nanogels for integration of optical pH-sensing, tumor cell imaging, and drug delivery

In-situ immobilization of quantum dots in polysaccharide-based nanogels for integration of optical pH-sensing, tumor cell imaging, and drug delivery

A Facile and Green Synthetic Route for Preparation of Heterostructure Fe₃O₄@Au Nanocomposites

Superparamagnetic Nanoparticles as High Efficiency Magnetic Resonance Imaging T₂ Contrast Agent

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Core@shell nanomaterials: gold-coated magnetic oxide nanoparticles

Cited by 192 publications

References 85 publications

In-situ immobilization of quantum dots in polysaccharide-based nanogels for integration of optical pH-sensing, tumor cell imaging, and drug delivery

In-situ immobilization of quantum dots in polysaccharide-based nanogels for integration of optical pH-sensing, tumor cell imaging, and drug delivery

A Facile and Green Synthetic Route for Preparation of Heterostructure Fe3O4@Au Nanocomposites

Superparamagnetic Nanoparticles as High Efficiency Magnetic Resonance Imaging T2 Contrast Agent

Contact Info

Product

Resources

About

A Facile and Green Synthetic Route for Preparation of Heterostructure Fe₃O₄@Au Nanocomposites

Superparamagnetic Nanoparticles as High Efficiency Magnetic Resonance Imaging T₂ Contrast Agent