Core–shell molecularly imprinted particles

Wan, Libin; Chen, Zhiliang; Huang, Chuixiu; Shen, Xiantao

doi:10.1016/j.trac.2017.08.010

Cited by 74 publications

(23 citation statements)

References 93 publications

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“…1) [7]. To date, molecular imprinting has proven to be the most efficient and versatile technique for incorporating specific molecular recognition sites into polymers leading to polymeric artificial receptors, i.e., the molecularly imprinted polymers (MIPs) [29,30]. In principle, by means of rational molecular design and chemical synthesis, molecular imprinting allows the rapid and inexpensive generation of synthetic receptors towards almost any target molecules.…”

Section: Molecular Imprinting Strategymentioning

confidence: 99%

Emerging functional materials based on chemically designed molecular recognition

Chen

Tian

et al. 2020

BMC Mat

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The specific interactions responsible for molecular recognition play a crucial role in the fundamental functions of biological systems. Mimicking these interactions remains one of the overriding challenges for advances in both fundamental research in biochemistry and applications in material science. However, current molecular recognition systems based on host-guest supramolecular chemistry rely on familiar platforms (e.g., cyclodextrins, crown ethers, cucurbiturils, calixarenes, etc.) for orienting functionality. These platforms limit the opportunity for diversification of function, especially considering the vast demands in modern material science. Rational design of novel receptor-like systems for both biological and chemical recognition is important for the development of diverse functional materials. In this review, we focus on recent progress in chemically designed molecular recognition and their applications in material science. After a brief introduction to representative strategies, we describe selected advances in these emerging fields. The developed functional materials with dynamic properties including molecular assembly, enzymelike and bio-recognition abilities are highlighted. We have also selected materials with dynamic properties in contract to traditional supramolecular host-guest systems. Finally, the current limitations and some future trends of these systems are discussed.

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Section: Molecular Imprinting Strategymentioning

confidence: 99%

Emerging functional materials based on chemically designed molecular recognition

Chen

Tian

et al. 2020

BMC Mat

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“…To broaden the application scope, multifunctional SPP MIPs have attracted increasing attention in separation. A current review discusses the recent developments of MIPs with a nonimprinted core (Core@MIP particles) and MIPs with a non-imprinted shell (MIP@Shell particles) [66]. In addition, other novel miscellaneous SPP MIPs with a hollow-core, a semi-shell, or an emptyshell are summarized.…”

Section: Molecularly Imprinted Polymersmentioning

confidence: 99%

New developments and possibilities of wide-pore superficially porous particle technology applied for the liquid chromatographic analysis of therapeutic proteins

Bobály

Veuthey

Guillarme

et al. 2018

Journal of Pharmaceutical and Biomedical Analysis

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This review paper discusses the success of columns packed with superficially porous particles (SPP) in liquid chromatography for the analysis of peptides and proteins. First, it summarizes the history of SPP, including the development of different SPP generations from particles of 50 μm to sub-2 μm. It also critically discusses the improved kinetic performance of SPP particles in comparison to fully porous particles. The current trends and applications of columns packed with SPPs for the analysis of peptides and proteins (including mAbs and ADC at the intact and sub-unit levels) are shown, as well. Finally, some of the potential perspectives for this technology are also described, including the radially oriented mesopores or the applicability of the technology for chiral separations.

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“…This has opened a new window of possibilities for developing new analytical methods [ 9 , 10 , 11 ]. In this way, an innovative way to synthesize novel MIPs is the incorporation of nanoparticles to their structure [ 12 , 13 ]. The combination of these two materials (polymer and nanoparticles) gives rise to a hybrid material with potential and new properties.…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Polymer Micro- and Nano-Particles: A Review

2020

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In recent years, molecularly imprinted polymers (MIPs) have become an excellent solution to the selective and sensitive determination of target molecules in complex matrices where other similar and relative structural compounds could coexist. Although MIPs show the inherent properties of the polymers, including stability, robustness, and easy/cheap synthesis, some of their characteristics can be enhanced, or new functionalities can be obtained when nanoparticles are incorporated in their polymeric structure. The great variety of nanoparticles available significantly increase the possibility of finding the adequate design of nanostructured MIP for each analytical problem. Moreover, different structures (i.e., monolithic solids or MIPs micro/nanoparticles) can be produced depending on the used synthesis approach. This review aims to summarize and describe the most recent and innovative strategies since 2015, based on the combination of MIPs with nanoparticles. The role of the nanoparticles in the polymerization, as well as in the imprinting and adsorption efficiency, is also discussed through the review.

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Core–shell molecularly imprinted particles

Cited by 74 publications

References 93 publications

Emerging functional materials based on chemically designed molecular recognition

Emerging functional materials based on chemically designed molecular recognition

New developments and possibilities of wide-pore superficially porous particle technology applied for the liquid chromatographic analysis of therapeutic proteins

Molecularly Imprinted Polymer Micro- and Nano-Particles: A Review

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