Core/Shell Iron Oxide@Gold nanoparticles for dual-modal CT/MRI imaging

Betzer, Oshra; Motiei, Menachem; Dreifuss, Tamar; Sadan, Tamar; Omer, Noam; Blumenfeld‐Katzir, Tamar; Liu, Zhuang; Ben‐Eliezer, Noam; Popovtzer, Rachela

doi:10.1117/12.2548430

Cited by 4 publications

(3 citation statements)

References 62 publications

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“…The hydrodynamic diameter increased from 21 nm (SPIONs) to 41 nm (SPIONs@Au), suggesting the formation of a stable and colloidal core–shell with Zeta potential equal to −54 mV. Indeed, an absorption band centered in a range of 500–530 nm is characteristic of gold particles at the nanoscale [ 28 , 29 , 30 ], and the SPIONs@Au remain with a magnetic behavior due to the iron core. The confirmation of the non-formation of gold nanoparticles occurred through the exposure of these nanoparticles to an external magnetic field, in which the supernatant obtained was quantified, showing no absorption band in UV-Visible spectra ( Figure 1 A).…”

Section: Discussionmentioning

confidence: 99%

Gold-Coated Superparamagnetic Iron Oxide Nanoparticles Functionalized to EGF and Ce6 Complexes for Breast Cancer Diagnoses and Therapy

et al. 2022

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Superparamagnetic iron oxide nanoparticles (SPIONs) have some limitations in the physiological environment, however, a modification on their surface, such as a core–shell structure with gold (SPIONs@Au), can enhance their applicability. In this study, SPIONs were synthesized by the chemical coprecipitation method, stabilized by sodium citrate, and followed by the gold-coating process. SPIONs@Au were functionalized with EGF-α-lipoic acid and chlorin e6 (Ce6)-cysteamine complexes, composing a Theranostic Nanoprobe (TP). The outcomes showed that the SPIONs@Au had changed in color to red and had an absorption band centered at 530 nm. The coating was verified in the TEM micrographs in bright and dark fields by EDS mapping, which indicated the presence of Au and Fe. The Ce6-cysteamine complex had a resonant band at 670 nm that enabled the diagnosis of biological samples using fluorescence analysis. In the measure of TNBC cell uptake, the maximum value of TP fluorescence intensity was obtained within 4 h of internalization. At 2 h, the incorporation of the TP in the cytoplasm as well as in the nuclei was observed, suggesting that it could be employed as a diagnostic marker. The PTT results showed significant percentages of apoptosis in the TNBC cell line, which confirms the efficacy of the TP.

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Section: Discussionmentioning

confidence: 99%

Gold-Coated Superparamagnetic Iron Oxide Nanoparticles Functionalized to EGF and Ce6 Complexes for Breast Cancer Diagnoses and Therapy

et al. 2022

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“…The magnetic ferrite nanoparticles steered new advancements for specific imaging of cancer tissue and significantly contributed to the field of oncology [81]. The high distribution capacity and crystallinity offer to exhibit superior harmful contrast enhancements for target-specific tumor imaging that subsequently provide excellent imaging and targeting abilities for in vitro imaging applications [82]. In clinical use of MRI, cobalt ferrites induced high signal intensity of T2 contrast agents compared to iron oxide nanoparticles to diagnose many diseases in the liver and spleen for MR contrast agents [83].…”

Section: Image Contrast Agents In Mrimentioning

confidence: 99%

Green Synthesis of Cobalt Ferrite Nanoparticles: An Emerging Material for Environmental and Biomedical Applications

Tamboli¹,

Patange²,

Mohanta

et al. 2023

Journal of Nanomaterials

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Research and utilization of nanotechnology are growing exponentially in every aspect of life. The constant growth of applications for magnetic nanoparticles, specifically nanoferrites, attracted many researchers. Among them, nanocobalt ferrite is the most crucial and studied magnetic nanoparticle. Environmentally benign synthetic methods became necessary to minimize environmental and occupational hazards. Green synthesis approaches in science and technology are now widely applied in the synthesis of nanomaterials. Herein, we reviewed recent advances in synthesizing nanocobalt ferrites and their composites using various scientific search engines. Subsequently, various applications were discussed, such as environmental (treatment of water/wastewater, photocatalytic degradation of dyes, and nanosorbent for environmental remediation) and biomedical (nanobiosensors for cancer diagnosis at the primary stage, effective targeted drug delivery, magnetic resonance imaging, hyperthermia, and potential drug candidates against cancer and microbial infections). This review offers comprehensive knowledge on how to choose appropriate natural resources for the green synthesis of nanocobalt ferrite and the benefits of this approach compared to conventional methods.

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“…We can, therefore, infer that the gold mass ratio was not sufficient to produce CT contrast and likely the coating would need to be much thicker to be successful in the future trials. 27…”

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confidence: 99%

Fibrinogen aptamer functionalized gold-coated iron-oxide nanoparticles for targeted imaging of thrombi

et al. 2022

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Core/Shell Iron Oxide@Gold nanoparticles for dual-modal CT/MRI imaging

Cited by 4 publications

References 62 publications

Gold-Coated Superparamagnetic Iron Oxide Nanoparticles Functionalized to EGF and Ce6 Complexes for Breast Cancer Diagnoses and Therapy

Gold-Coated Superparamagnetic Iron Oxide Nanoparticles Functionalized to EGF and Ce6 Complexes for Breast Cancer Diagnoses and Therapy

Green Synthesis of Cobalt Ferrite Nanoparticles: An Emerging Material for Environmental and Biomedical Applications

Fibrinogen aptamer functionalized gold-coated iron-oxide nanoparticles for targeted imaging of thrombi

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