Core-shell gold-nickel nanostructures as highly selective and stable nonenzymatic glucose sensor for fermentation process

Abstract

non-enzymatic electrodes based on noble metals have excellent selectivity and high sensitivity in glucose detection but no such shortcomings as easy to be affected by pH, temperature, and toxic chemicals. Herein, spherical gold-nickel nanoparticles with a core-shell construction (Au@ni) are prepared by oleylamine reduction of their metal precursors. At an appropriate Au/ni ratio, the core-shell Au@ni nanoparticles as a sensor for glucose detection combine the high electrocatalytic activity, good selectivity and biological compatibility of Au with the remarkable tolerance of ni for chlorine ions (cl −) and poisoning intermediates in catalytic oxidation of glucose. this electrode exhibits a low operating voltage of 0.10 V vs. SCE for glucose oxidation, leading to higher selectivity compared with other Auand Ni-based sensors. The linear range for the glucose detection is from 0.5 mmol L −1 to 10 mmol L −1 with a rapid response time of ca. 3 s, good stability, sensitivity estimated to be 23.17 μA cm −2 mM −1 , and a detection limit of 0.0157 mM. The sensor displays high anti-toxicity, and is not easily poisoned by the adsorption of cl − in solution.

Recent Advances in Non-Enzymatic Glucose Sensors Based on Metal and Metal Oxide Nanostructures for Diabetes Management- A Review

“…In addition, the authors also noted that these gold microelectrodes hold promise for the miniaturisation of the glucose-sensing systems. In another similar work, NEGS were developed based on gold-nickel nanoparticles and high sensitivity of 23.17 μA cm −2 mM −1 was observed along with a LOD of 0.0157 mM in under 3 s ( Gao et al, 2020 ). In addition, this sensor was undisturbed by toxic chemicals like chloride molecules and thus remained active for long durations.…”

“…Gold-based NEGS has also been shown to possess high stability, reproducibility, and selectivity for glucose molecules. The biggest advantage of these gold-based sensors is that they remain unaffected by changes in pH, temperature, and other chemicals in the vicinity ( Gao et al, 2020 ). A novel and stable NEGS based on gold nanoclusters was developed by Hovancová et al (2019) .…”

Recent Advances in Enzymatic and Non-Enzymatic Electrochemical Glucose Sensing

“…Particularly relevant are noble metals such as Pt, nickel (Ni), Ag, zinc, and Au, which are highly utilised to develop novel non-enzymatic glucose sensors [ 24 , 141 , 142 , 143 ]. The ion contamination limitation can be eliminated using alkaline conditions on the electrode surface, as the hydroxyl groups (OH) eliminates the chloride adsorption to the surface [ 29 , 144 ].…”

“…However, contrary to Pt its glucose oxidation mechanism is still vague, requiring further studies. In this case, the cyclic voltammetry graph only presents two regions, corresponding to the double layer and Au oxide region [ 26 , 29 , 105 , 155 , 167 ]. Previous studies seem to indicate a dependence between the oxidation mechanism and the presence of surface oxides such as Au(OH) [ 155 ].…”

Non-enzymatic sensor for determination of glucose based on PtNi nanoparticles decorated graphene

“…Glucose sensors have attracted more attention in the medical application of blood glucose sensing. Especially for diabetic patients, the precise monitoring and careful control of the level of glucose in human blood are essential 1,2 . For nowadays, most of the traditional methods for measuring blood glucose levels are involved in electrochemical or colorimetric readout systems.…”