Core-sheath nanostructured chitosan-based nonwovens as a potential drug delivery system for periodontitis treatment

Santos, Danilo Martins dos; Chagas, Paulo Augusto Marques; Leite, Ilaiáli Souza; Inada, Natália Mayumi; Annunzio, Sarah Raquel de; Fontana, Carla Raquel; Filho, Sérgio Paulo Campana; Corrêa, Daniel S.

doi:10.1016/j.ijbiomac.2019.09.124

Cited by 56 publications

(44 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The biggest characteristic of coreshell structure is that the release process of drugs can be better controlled to prevent drugs from being released prematurely, and the existence of core-shell structure can avoid the destruction of physical and chemical properties of drugs in the core layer by the external environment. Santos et al (166) constructed chitosan/PVA-TCH nanofibers with coaxial electrospinning. The hydrophilicity, swelling rate, and degradation rate of the nonwoven fibers reduced but the mechanical properties of the nonwoven fibers improved by using genipin-alcohol solution.…”

Section: Functional Applications Of Structural Electrospun Fibersmentioning

confidence: 99%

Structural design toward functional materials by electrospinning: A review

et al. 2020

View full text Add to dashboard Cite

Electrospinning as one of the most versatile technologies have attracted a lot of scientists’ interests in past decades due to its great diversity of fabricating nanofibers featuring high aspect ratio, large specific surface area, flexibility, structural abundance, and surface functionality. Remarkable progress has been made in terms of the versatile structures of electrospun fibers and great functionalities to enable a broad spectrum of applications. In this article, the electrospun fibers with different structures and their applications are reviewed. First, several kinds of electrospun fibers with different structures are presented. Then the applications of various structural electrospun fibers in different fields, including catalysis, drug release, batteries, and supercapacitors, are reviewed. Finally, the application prospect and main challenges of electrospun fibers are discussed. We hope that this review will provide readers with a comprehensive understanding of the structural design and applications of electrospun fibers in different fields.

show abstract

Section: Functional Applications Of Structural Electrospun Fibersmentioning

confidence: 99%

Structural design toward functional materials by electrospinning: A review

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Electrospinning technique is the mostly used method for the production of nano bers, which allows adjustment of ber size, drug loading and mechanical properties can be adjusted [169]. In a recent study, the antibacterial activity of chitosan nano ber, cross-linked with tetracycline comprising polyvinyl alcohol (PVA) was evaluated and enhanced antibacterial activity against a wide range of periodontal pathogens was demonstrated [170]. Mahmoud et al [171] have developed polymeric electrospun bers using PLGA, poly(L-lactic acid) (PLLA), and polycaprolactone (PCL) alone or blended with polyethylene oxide (PEO), incorporated with an antimicrobial peptide (BAR), and evaluated their safety and functionality against P. gingivalis/S.…”

Section: J Periodontol • January 2002mentioning

confidence: 99%

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

Şenel

Özdoğan

2021

Preprint

View full text Add to dashboard Cite

Oral health reflects the general health and it is fundamental to well-being and quality of life. An infection in the oral cavity can be associated with serious complications in human health. Local therapy of these infections offers many advantages over systemic drug administration, targeting directly to the diseased area while minimizing systemic side effects. Specialized drug delivery systems into the oral cavity have to be designed in such a fashion that they resist to the aqueous environment that is constantly bathed in saliva and subject to mechanical forces. Additionally, a prolonged release of drug should also be provided, which would enhance the efficacy and also decrease the repeated dosing. This review is aimed to summarize the current most relevant findings related to local drug delivery of various drug groups for prevention and treatment of infections (viral, bacterial, fungal) and infection related manifestations in the oral cavity. Current therapeutic challenges in regard to effective local drug delivery systems will be discussed and the recent approaches to overcome these obstacles will be reviewed. Finally, future prospects will be overviewed to promote novel strategies that can be implemented in clinical management for prevention and treatment of oral infections.

show abstract

“…Therefore, the drug release rate is dependent on the chemical structure and architectures of the polymeric carrier system, the physicochemical properties of the solutes, but it is also influenced by several other parameters in the surrounding environment, e.g., pH and temperature [ 54 , 55 ]. The kinetics of this release can be explained by the mathematical equations dealing with the drug release methodology [ 56 , 57 , 58 ]. In many cases, it is desirable to have a controlled delivery system that requires the maintenance of a constant drug concentration for an extended period of time within the therapeutic range without fluctuations in concentration levels [ 59 , 60 ].…”

Section: Drug Delivery Devicesmentioning

confidence: 99%

“…An additional advantage of using biodegradable material is the absence of the need to revisit a dentist to remove the device. Natural occurring polymers such as chitosan, cellulose, alginate, and synthetic polymers such as poly(ε-caprolactone) (PCL), poly( d,l -lactide) (PLA), poly-( d,l -lactide-co-glycolide) (PLGA), poly- (vinylpyrrolidone) (PVP) and poly(vinyl alcohol) (PVAL) have been extensively investigated [ 58 , 67 , 70 , 71 , 72 , 73 , 74 , 75 ]. Fibers are still a relatively popular form of therapeutic delivery systems and are fabricated mainly by electrospinning.…”

Section: Drug Delivery Devicesmentioning

confidence: 99%

“…Chitosan is also another polymer that has been investigated extensively. Low molecular weight and highly deacetylated chitosan cross-linked with tetracycline hydrochloride containing poly(vinyl alcohol) (PVA) as the core layer, was used to fabricate of DDS by coaxial electrospinning method in a recent study [ 58 ]. The author evaluated physicochemical and biological properties of resulting nonwoven and observed sustained release of tetracycline hydrochloride from the drug delivery device for up to 14 days, while the device was also exhibiting cytocompatibility as well as antibacterial activity against a wide range of periodontal pathogens.…”

Section: Drug Delivery Devicesmentioning

confidence: 99%

See 1 more Smart Citation

Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease

et al. 2020

View full text Add to dashboard Cite

Periodontitis (PD) is a chronic inflammatory disease of periodontal tissues caused by pathogenic microorganisms and characterized by disruption of the tooth-supporting structures. Conventional drug administration pathways in periodontal disease treatment have many drawbacks such as poor biodistribution, low selectivity of the therapeutic effect, burst release of the drug, and damage to healthy cells. To overcome this limitation, controlled drug delivery systems have been developed as a potential method to address oral infectious disease ailments. The use of drug delivery devices proves to be an excellent auxiliary method in improving the quality and effectiveness in periodontitis treatment, which includes inaccessible periodontal pockets. This review explores the current state of knowledge regarding the applications of various polymer-based delivery systems such as hydrogels, liposomes, micro-, and nanoparticles in the treatment of chronic periodontal disease. Furthermore, to present a more comprehensive understanding of the difficulties concerning the treatment of PD, a brief description of the mechanism and development of the disease is outlined.

show abstract

Core-sheath nanostructured chitosan-based nonwovens as a potential drug delivery system for periodontitis treatment

Cited by 56 publications

References 81 publications

Structural design toward functional materials by electrospinning: A review

Structural design toward functional materials by electrospinning: A review

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease

Contact Info

Product

Resources

About