Cordyceps sinensis Extracts Attenuate Aortic Transplant Arteriosclerosis in Rats

Zhang, Yan; Yang, Mei; Gong, Shuwen; Yang, Yu Shih; Chen, Bicheng; Cai, Yong; Zheng, Shimin; Yang, Yirong; Xia, Peng

doi:10.1016/j.jss.2011.02.027

Cited by 8 publications

(7 citation statements)

References 35 publications

(33 reference statements)

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“…A mor e rece nt stud y focuses on the effect of pol ysacch aride fro m the fruiting bodies of cultur ed C. sinensis on splenic lym phoc ytes, macr opha ges, dela yed -type hypersensiti vity (DTH), anti-oxid ant activ ity and cytokine expre ssion in BALB/c mice exposed to 60 Co (Zhang et al, 2011a;Zhang et al, 2011b). An imm unosuppr esion model was used in this stud y by subjecting the mice to the ionizing rad iation of 60 Co ther eb y stimul ating inflammation and causing suppr ession of the imm une system by way of re press ing ly mphoc yte pro lifer ation.…”

Section: Immu No-stimula Tionmentioning

confidence: 99%

“…In vivo antioxid ant activ ities in the serum of 60 Co irr adiated BALB/c mice were in ve stigated using tw o assa ys in vo lving malond ialdeh yde (MDA) and super oxide dism utase (SOD) detectio n (Zhang et al, 2011a;Zhang et al, 2011b ). MD A is a lipid perox idation indicator while SOD prote cts the cell fro m oxidati ve dama ge by con verting super oxide anions into hydrogen perox ide.…”

Section: Antioxidantmentioning

confidence: 99%

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Properties of Cordyceps Sinensis: A review

Chen

Wang

Nie

et al. 2013

Journal of Functional Foods

120

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Extraction Polysaccha ride Nucleoside Antioxidant Antiaging Immune-stim ulant A B S T R A C T A gr eat mystique and aura surrounds Cor dyceps sinensis (syn.: Cephalosporium sinensis ), an endoparasitic fungus which has claims of anti-cancer and anti-aging properties. Much resear ch has been conduc ted over the years on crude extracts and its bioactivity . More resear ch is no w focused on culturing C. sinensis and on isolating and identifying pure co mpound s no vel to C. sinensis in an attempt to allev iate strain on dem and for the natural fung i. Se ver al polysacc hari des, nucleosides and sterols all ha ve had re ports of promoting health both in vitro and in vivo . Specific and no vel compound s which are cha racteristic to C. sinensis are emer ging with re ports of two new epipol ythiod ioxopiperazines, gliocladic illins A and B capab le of inhibiting gro wth of HeLa , Hep G2 and MCF-7 tumor cells. Exclusiv e to natural C. sinensis, five constituent s of cor dysinin (A-E) has also been re ported for the first time and has been linked to anti-inflammatory properties. Although it ma y still be premature to belie ve these results should translate into pharmaceutica l use, there is sufficient evide nce to warr ant further resear ch. Cro wn Cop yright Ó

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Section: Immu No-stimula Tionmentioning

confidence: 99%

Section: Antioxidantmentioning

confidence: 99%

Properties of Cordyceps Sinensis: A review

Chen

Wang

Nie

et al. 2013

Journal of Functional Foods

120

View full text Add to dashboard Cite

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“…Similarly, O . sinensis extracts attenuated aortic transplant arteriosclerosis in rats (Zhang et al ., ).…”

Section: Functional Activities and Mechanisms Of O Sinensismentioning

confidence: 97%

The Mechanisms of Pharmacological Activities ofOphiocordyceps sinensisFungi

Huang

Chen

et al. 2016

Phytother. Res.

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The entomopathogenic fungus Ophiocordyceps sinensis, formerly known as Cordyceps sinensis, has long been used as a traditional Chinese medicine for the treatment of many illnesses. In recent years its usage has increased dramatically because of the improvement of people's living standard and the emphasis on health. Such demands have resulted in over-harvesting of this fungus in the wild. Fortunately, scientists have demonstrated that artificially cultured and fermented mycelial products of O. sinensis have similar pharmacological activities to wild O. sinensis. The availability of laboratory cultures will likely to further expand its usage for the treatment of various illnesses. In this review, we summarize recent results on the pharmacological activities of the components of O. sinensis and their putative mechanisms of actions. Copyright © 2016 John Wiley & Sons, Ltd.

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“…Additionally, cordycepin possesses an anti-atherogenic effect (10)(11)(12). One study demonstrated that cordycepin is able to inhibit cell growth, induce G1-phase cell-cycle arrest, downregulate the expression of cyclins and cyclin-dependent kinase, and upregulate the expression of p27 kip1 in VSMCs (6).…”

Section: Introductionmentioning

confidence: 99%

Cordycepin inhibits vascular adhesion molecule expression in TNF-α-stimulated vascular muscle cells

Yan

Huang

Duan

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Atherosclerosis is a chronic inflammatory disease, which is associated with the increased expression of adhesion molecules in vascular smooth muscle cells (VSMCs). Cordycepin is one of the major bioactive components of Ophiocordyceps sinensis that has been demonstrated to exert anti-atherogenic activity; however, its molecular mechanisms are poorly understood. The aim of the present study was to examine the in vitro effects of cordycepin on the tumor necrosis factor (TNF)-α-induced suppression of adhesion molecule expression. The results of the present study demonstrated that cordycepin markedly inhibited the expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) in TNF-α-stimulated human aortic vascular smooth muscle cells (HA-VSMCs). Cordycepin significantly inhibited the TNF-α-induced mitogen-activated protein kinase (MAPK) and protein kinase B (Akt) activation (P<0.05), markedly inhibited the TNF-α-induced expression level of nuclear factor (NF)-κB p65 and markedly prevented the TNF-α-associated degradation of IκBα in HA-VSMCs. The results of the present study suggest that cordycepin inhibits the expression of VCAM-1 and ICAM-1 in TNF-α-stimulated HA-VSMCs via downregulating the MAPK/Akt/NF-κB signaling pathway. Therefore, cordycepin may have a potential therapeutic application for preventing the advancement of atherosclerotic lesions.

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Cordyceps sinensis Extracts Attenuate Aortic Transplant Arteriosclerosis in Rats

Cited by 8 publications

References 35 publications

Properties of Cordyceps Sinensis: A review

Properties of Cordyceps Sinensis: A review

The Mechanisms of Pharmacological Activities ofOphiocordyceps sinensisFungi

Cordycepin inhibits vascular adhesion molecule expression in TNF-α-stimulated vascular muscle cells

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