Cordyceps cicadae NTTU 868 mycelium prevents CCl 4 -induced hepatic fibrosis in BALB/c mice via inhibiting the expression of pro-inflammatory and pro-fibrotic cytokines

Ke, Bo-Jun; Lee, Chun-Lin

doi:10.1016/j.jff.2018.02.010

Cited by 18 publications

(9 citation statements)

References 40 publications

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“…The primary protective mechanisms of some antifibrotic agents result from their antioxidative capabilities [23]. In this study, a series of parameters was used to measure the oxidative stress in rats.…”

Section: Discussionmentioning

confidence: 99%

Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats

Chen

Zhou

et al. 2018

BioMed Research International

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Dimethylnitrosamine (DMN) is a potent hepatotoxin, carcinogen, and mutagen. In our previous study, a candidate gallic acid (GA) that widely exists in food and fruit was selected for its capability to alleviate DMN toxicity in vivo. We aimed to investigate the therapeutic potential of GA against DMN-induced liver fibrosis. During the first four weeks, DMN was administered to rats via intraperitoneal injection every other day, except the control group. GA or silymarin was given to rats by gavage once daily from the second to the sixth week. GA significantly reduced liver damage in serum parameters and improved the antioxidant capacity in liver and kidney tissues. Cytokines involved in liver fibrosis were measured at transcriptional and translational levels. These results indicate that GA exhibits robust antioxidant and antifibrosis effects and may be an effective candidate natural medicine for liver fibrosis treatment.

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Section: Discussionmentioning

confidence: 99%

Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats

Chen

Zhou

et al. 2018

BioMed Research International

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“…Cordycepin in Cordyceps militaris has been considered as one of the functional components with neuroprotection in past studies [39]. Cordyceps cicadae has been gradually discovered in recent years because its HEA was proven to perform liver protection [4], renoprotection [2], and anti-diabetic effect [39,40]. Some studies have argued that HEA in C. cicadae can limit NF-κB signal pathways and alleviate LPS-induced inflammatory responses [1].…”

Section: Discussionmentioning

confidence: 99%

“…Cordyceps cicadae, a Chinese traditional food fungus, has antioxidation, anti-inflammation [1], blood sugar regulation (Li et al, 2018), renal function improvement [2,3], liver protection [4], and neuroprotection [5] properties. The functional components of C. cicadae are adenosine, N(6)-(2-Hydroxyethyl) adenosine (HEA), and polysaccharides [6,7], which are proven to have antioxidation, anti-inflammatory, and anti-aging properties [8].…”

Section: Introductionmentioning

confidence: 99%

Cordyceps cicadae NTTU 868 Mycelium with The Addition of Bioavailable Forms of Magnesium from Deep Ocean Water Prevents the Aβ40 and Streptozotocin-Induced Memory Deficit via Suppressing Alzheimer’s Disease Risk Factors and Increasing Magnesium Uptake of Brain

Lee

2021

Fermentation

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Alzheimer’s disease (AD) is a common neurodegenerative disease characterized by continuous accumulation of β-amyloid (Aβ) in the brain. Deep ocean water (DOW) with rich inorganic salts and minerals was proven to promote fungi growth and metabolism. Cordyceps cicada, a functional food fungus, can produce higher anti-oxidant and anti-inflammatory compounds including adenosine, polysaccharide, and N(6)-(2-Hydroxyethyl) adenosine (HEA). This study used DOW as the culture water of C. cicadae NTTU 868 for producing DOW-cultured C. cicadae (DCC), and further investigated the effects and mechanisms on improving the memory deficit and repressing risk factors expressions in Aβ40 and streptozotocin (STZ)-induced Alzheimer’s disease rats model. In the results, DCC including mycelium and filtrate had adenosine, HEA, polysaccharide, and intracellular Mg2+ after fermentation with DOW. DCC had more effect on the improvement of memory deficit because it suppressed Aβ40 and streptozotocin (STZ) infusion caused BACE, pro-inflammatory factors expressions, and Aβ40 accumulation by increasing sRAGE expression in the brain. Furthermore, DCC enhanced the MAGT1 expression due to high organic magnesium, which can reverse Aβ40-induced cortex magnesium deficiency and further repress Aβ40 accumulation.

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“…In our previous study, the submerged culture product of C. cicadae has been proven to prevent the development of liver-fibrosis in mice induced by CCl 4 injection. Furthermore, HEA, adenosine, and polysaccharides produced by submerged culture were proven as the functional components for liver protection (Ke and Lee 2018). Therefore, submerged culture may be the novel culture to instead of solid fermentation for producing HEA and polysaccharides.…”

Section: Introductionmentioning

confidence: 99%

Using submerged fermentation to fast increase N6-(2-hydroxyethyl)-adenosine, adenosine and polysaccharide productions of Cordyceps cicadae NTTU 868

Lee

2019

AMB Expr

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Cordyceps cicadae is a well-known traditional Chinese medicine for treating palpitations and eye diseases. It contains several bioactive compounds such as adenosine, N6-(2-hydroxyethyl)-adenosine (HEA), and polysaccharide. Those bioactive compounds have been reported to perform anti-oxidation and anti-inflammatory properties and provide renal protection. In this study, we researched different fermentation conditions in order to enhance the biomass, adenosine, HEA, and polysaccharide productions of C. cicadae NTTU 868. Solid fermentation was carried out with different grain substrates (barley, oat, rice and wheat). Various submerged fermentation scales were used to produce the C. cicadae NTTU 868 mycelium. The results of solid fermentation revealed that C. cicadae NTTU 868 produced higher adenosine and HEA concentrations in oat rather than in other substrates. C. cicadae NTTU 868 mycelium had obtained the highest concentrations of adenosine and HEA on Day 2 as using the small-scale submerged fermentation. Furthermore, potato dextrose broth with extra 0.2% of yeast extract was able to result in higher HEA concentration. In conclusion, using submerged fermentation to culture C. cicadae NTTU 868 resulted in more efficient adenosine, HEA, and polysaccharide productions than using solid-fermentation, especially when 0.2% of yeast extract was used in the PDB. Importantly, this can be easily scaled-up in the fermentation industry.

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Cordyceps cicadae NTTU 868 mycelium prevents CCl 4 -induced hepatic fibrosis in BALB/c mice via inhibiting the expression of pro-inflammatory and pro-fibrotic cytokines

Cited by 18 publications

References 40 publications

Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats

Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats

Cordyceps cicadae NTTU 868 Mycelium with The Addition of Bioavailable Forms of Magnesium from Deep Ocean Water Prevents the Aβ40 and Streptozotocin-Induced Memory Deficit via Suppressing Alzheimer’s Disease Risk Factors and Increasing Magnesium Uptake of Brain

Using submerged fermentation to fast increase N6-(2-hydroxyethyl)-adenosine, adenosine and polysaccharide productions of Cordyceps cicadae NTTU 868

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