Cordycepin Suppresses Thymic Stromal Lymphopoietin Expression &lt;i&gt;via&lt;/i&gt; Blocking Caspase-1 and Receptor-Interacting Protein 2 Signaling Pathways in Mast Cells

Yoou, Myoung-schook; Jin, Mu Hyun; Lee, So Young; Lee, Sang Hwa; Kim, Byung-Hyun; Roh, Seok Seon; Choi, In Hwa; Lee, Myeong Soo; Kim, Hyung-Min; Jeong, Hyun‐Ja

doi:10.1248/bpb.b15-00631

Cited by 11 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Papers selected for analysis were examined for data of effects of cordycepin on cytokines, inflammation or regulation of inflammatory genes in tissue culture. We found 54 papers with data on these subjects [ 28 , 31 , 36 , 43 , 69 , 70 , 71 , 72 , 76 , 78 , 88 , 89 , 94 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 117 , 133 , 270 , 274 , 286 , 326 , 328 , 330 , 332 , 340 , 341 , 342 , 343 , 344 , 345 , 346 , 347 , 348 ,…”

Section: Methodsmentioning

confidence: 99%

“…Cordycepin-induced changes in the gene products were noted as increased, unchanged or decreased. We found 38 papers describing such changes [ 28 , 69 , 70 , 71 , 72 , 76 , 88 , 89 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 106 , 108 , 109 , 110 , 112 , 113 , 117 , 270 , 286 , 326 , 330 , 340 , 341 , 342 , 343 , 344 , 345 , 346 , 347 , 348 , 349 ]. In addition, notes were gathered on the effects on the nuclear localisation, level, phosphorylation and DNA binding of NFĸB in the 54 papers found for this subject.…”

Section: Methodsmentioning

confidence: 99%

“…Papers selected for analysis were examined for data of effects of cordycepin on cytokines, inflammation or regulation of inflammatory genes in tissue culture. We found 54 papers with data on these subjects [28,31,36,43,[69][70][71][72]76,78,88,89,94,[96][97][98][99][100][101][102][103][104][105][106][107][108][109][110][111][112][113][114]117,133,270,274,286,326,328,330,332,[340][341][342][343][344][345][346][347]…”

Section: Cellular Inflammationmentioning

confidence: 99%

See 2 more Smart Citations

A Systematic Review of the Biological Effects of Cordycepin

Radhi

Ashraf²,

Lawrence

et al. 2021

Molecules

View full text Add to dashboard Cite

We conducted a systematic review of the literature on the effects of cordycepin on cell survival and proliferation, inflammation, signal transduction and animal models. A total of 1204 publications on cordycepin were found by the cut-off date of 1 February 2021. After application of the exclusion criteria, 791 papers remained. These were read and data on the chosen subjects were extracted. We found 192 papers on the effects of cordycepin on cell survival and proliferation and calculated a median inhibitory concentration (IC50) of 135 µM. Cordycepin consistently repressed cell migration (26 papers) and cellular inflammation (53 papers). Evaluation of 76 papers on signal transduction indicated consistently reduced PI3K/mTOR/AKT and ERK signalling and activation of AMPK. In contrast, the effects of cordycepin on the p38 and Jun kinases were variable, as were the effects on cell cycle arrest (53 papers), suggesting these are cell-specific responses. The examination of 150 animal studies indicated that purified cordycepin has many potential therapeutic effects, including the reduction of tumour growth (37 papers), repression of pain and inflammation (9 papers), protecting brain function (11 papers), improvement of respiratory and cardiac conditions (8 and 19 papers) and amelioration of metabolic disorders (8 papers). Nearly all these data are consistent with cordycepin mediating its therapeutic effects through activating AMPK, inhibiting PI3K/mTOR/AKT and repressing the inflammatory response. We conclude that cordycepin has excellent potential as a lead for drug development, especially for age-related diseases. In addition, we discuss the remaining issues around the mechanism of action, toxicity and biodistribution of cordycepin.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Papers selected for analysis were examined for data of effects of cordycepin on cytokines, inflammation or regulation of inflammatory genes in tissue culture. We found 54 papers with data on these subjects [28,31,36,43,[69][70][71][72]76,78,88,89,94,[96][97][98][99][100][101][102][103][104][105][106][107][108][109][110][111][112][113][114]117,133,270,274,286,326,328,330,332,[340][341][342][343][344][345][346][347]…”

Section: Cellular Inflammationmentioning

confidence: 99%

See 1 more Smart Citation

A Systematic Review of the Biological Effects of Cordycepin

Radhi

Ashraf²,

Lawrence

et al. 2021

Molecules

View full text Add to dashboard Cite

show abstract

“…In the PMA plus calcium ionophore A23187 (PMACI)‐stimulated HMC‐1 human mast cell line, cordycepin decreases the production of IL‐8, IL‐1β, IL‐6, and TNF‐α, and inhibits the expression of TSLP by blocking the RIP2/Caspase‐1/NF‐κB pathways (Yoou et al, 2016). Another study shows that cordycepin significantly diminishes the production of IL‐13 by blocking PSTAT6.…”

Section: Anti‐inflammatory Activitymentioning

confidence: 99%

Anti‐inflammatory effects of cordycepin: A review

Tan

Song

Ren

et al. 2020

Phytotherapy Research

View full text Add to dashboard Cite

Cordycepin is the major bioactive component extracted from Cordyceps militaris. In recent years, cordycepin has received increasing attention owing to its multiple pharmacological activities. This study reviews recent researches on the anti-inflammatory effects and the related activities of cordycepin. The results from our review indicate that cordycepin exerts protective effects against inflammatory injury for many diseases including acute lung injury (ALI), asthma, rheumatoid arthritis, Parkinson's disease (PD), hepatitis, atherosclerosis, and atopic dermatitis. Cordycepin regulates the NF-κB, RIP2/Caspase-1, Akt/GSK-3β/p70S6K, TGF-β/Smads, and Nrf2/HO-1 signaling pathways among others. Several studies focusing on cordycepin derivatives were reviewed and found to down metabolic velocity of cordycepin and increase its bioavailability. Moreover, cordycepin enhanced immunity, inhibited the proliferation of viral RNA, and suppressed cytokine storms, thereby suggesting its potential to treat COVID-19 and other viral infections. From the collected and reviewed information, this article provides the theoretical basis for the clinical applications of cordycepin and discusses the path for future studies focusing on expanding the medicinal use of cordycepin. Taken together, cordycepin and its analogs show great potential as the next new class of anti-inflammatory agents.

show abstract

“…This condition leads to accelerate the dynamic for his subcutaneous. In such mechanism, solubilized wax substance promote skin turnover, some kind of cosmetics for lady [23][24][25][26][27][28][29][30][31].…”

Section: Phagocyte Augmentation Of Subcutaneous Macrophagementioning

confidence: 99%

A Constitution Dependent QOL Assessment

Yamaguchi¹

2017

J Tradi Med Clin Natur

View full text Add to dashboard Cite

According to the reports from Ministry of Health in each country, the average life spans were expanded over the past century. This trend is expected to be extended further in the future and at the same time continuous efforts should be made. That indicates that the quantitative objective, as one of the objectives people have aimed at since ancient times to attain the perpetual youth and longevity, are almost achieved in this way. However, as the next objective, it is necessary for us to be concerned about improving the more advanced quality of life.In an effort of improving the quality of life, other than the western medicine, we have attempted to bring many traditional medical practices, including the Oriental medicine, from various parts of the world into the medical field as alternative medicine. Judging both positive and negative aspects by the evaluation standard of the Western medicine, we try to obtain numerical values of QOL, and after that, set a numerical target for improvement of QOL. Some methods of alternative medicine taken in this review are acupuncture moxibustion, Chinese medicine and other traditional medicine. Above all, WHO suggests selecting the suzerain nation of acupuncture moxibustion, which has been developed in the Oriental countries and realized as a specialized cure, by raising good & bad points and ascertaining which nation advocating the best modeling method could be. At the moment for evaluating CAM, for example, what kind of methods is/are suitable for evaluating each CAM. We have been trying to propose the peripheral leukocyte is one of the best ways for evaluating CAM. Our trials are hot spring hydro therapy, acupuncture and moxibution, light exercise and undle heating. In these evaluations, we found the common results from leukocyte effects which exhibited strong correlation for the regulation. The contents are the result from the data showing the much in number tend to downly regulate, on the other hand lower number one is up-regulated. This kind of regulation showed within a 24 hrs, for the leukocyte subsets, granulocyte and lymphocyte are changed under circadian rhythm. So for purpose of evaluating leukocyte deviation, we set the point for evaluation at the same-time zone from the first set of evaluation. Under these condition, we got a same results reproductively that the whole number of leukocyte, and its subset, granulocyte and lymphocyte also regulated within a 24 hrs. This kind of phenomenon is the case that we confirm a lot of kind of CAM and repetition. However, the life span of leukocyte are at lease 3-4 days and no such a drastic apoptosis was induced such a stimulation. For the purpose of scientific explanation, we proposed that the emotional hormone are concern this change of leukocytes population. For the results of this hypothesis, there were reasonable change were seen in the peripheral blood about emotional hormone, adrenaline and dopamine. Other hormone concern thyroid grand was not changed significantly. In this review, I plan to collect evidence and...

show abstract

Cordycepin Suppresses Thymic Stromal Lymphopoietin Expression <i>via</i> Blocking Caspase-1 and Receptor-Interacting Protein 2 Signaling Pathways in Mast Cells

Abstract: Cordycepin (3′-deoxyadenosine) is one of the active components isolated from

Cited by 11 publications

References 27 publications

A Systematic Review of the Biological Effects of Cordycepin

A Systematic Review of the Biological Effects of Cordycepin

Anti‐inflammatory effects of cordycepin: A review

A Constitution Dependent QOL Assessment

Contact Info

Product

Resources

About