Anti‐inflammatory effects of cordycepin: A review

Tan, Lu; Song, Xiaominting; Ren, Yali; Wang, Miao; Guo, Chuanjie; Guo, Da‐Le; Gu, Yucheng; Li, Yuzhi; Cao, Zhixing; Deng, Yun

doi:10.1002/ptr.6890

Cited by 54 publications

(31 citation statements)

References 108 publications

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“…The structure of cordycepin consists of a purine molecule attached to one ribose sugar moiety [229]. The bioactivities demonstrated by this compound are antiaging, antiarthritic, anticancer, antidiabetic, antifungal, antihyperlipidemia, antiinflammatory, antimalarial, anti-osteoporotic, antioxidant, antiviral, hepato-protective, hypo-sexuality, immunomodulatory, weight-regulating, and many more nutraceutical and pharmaceutical applications in cardiovascular diseases, as well as general applications for maintaining good health [229][230][231][232][233][234]. Cordycepin isolated from Cordyceps militaris significantly inhibited the growth of MCF-7 human breast cancer cells with an IC 50 value of 9.58 µM [235].…”

Section: Other Bioactive Compoundsmentioning

confidence: 99%

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Niego

Rapior

Thongklang

et al. 2021

JoF

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Macrofungi production and economic value have been increasing globally. The demand for macrofungi has expanded rapidly owing to their popularity among consumers, pleasant taste, and unique flavors. The presence of high quality proteins, polysaccharides, unsaturated fatty acids, minerals, triterpene sterols, and secondary metabolites makes macrofungi an important commodity. Macrofungi are well known for their ability to protect from or cure various health problems, such as immunodeficiency, cancer, inflammation, hypertension, hyperlipidemia, hypercholesterolemia, and obesity. Many studies have demonstrated their medicinal properties, supported by both in vivo and in vitro experimental studies, as well as clinical trials. Numerous bioactive compounds isolated from mushrooms, such as polysaccharides, proteins, fats, phenolic compounds, and vitamins, possess strong bioactivities. Consequently, they can be considered as an important source of nutraceuticals. Numerous edible mushrooms have been studied for their bioactivities, but only a few species have made it to the market. Many species remain to be explored. The converging trends and popularity of eastern herbal medicines, natural/organic food product preference, gut-healthy products, and positive outlook towards sports nutrition are supporting the growth in the medicinal mushroom market. The consumption of medicinal mushrooms as functional food or dietary supplement is expected to markedly increase in the future. The global medicinal mushroom market size is projected to increase by USD 13.88 billion from 2018 to 2022. The global market values of promising bioactive compounds, such as lentinan and lovastatin, are also expected to rise. With such a market growth, mushroom nutraceuticals hold to be very promising in the years to come.

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Section: Other Bioactive Compoundsmentioning

confidence: 99%

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Niego

Rapior

Thongklang

et al. 2021

JoF

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“…Several previous review articles have illustrated the health-promoting effects of cordycepin [ 20 , 22 , 27 , 151 ]. A previous study also showed that cordycepin activates AMPK to block the activity of mTORC1 and mTORC2 complexes by unknown mechanisms [ 19 ].…”

Section: The Role Of Autophagy In the Health-promoting Effects Of Cordycepinmentioning

confidence: 99%

“…However, Cordyceps sinensis contains numerous substances, and the specific pure component responsible for the pharmacological activities remains elusive. Cordycepin is the major component in Cordyceps sinensis [ 18 , 19 ], and investigations of the positive effects of cordycepin on different diseases and health issues have boomed recently, with reviews showing its activities with anti-inflammatory effects [ 20 ], immunomodulatory effects [ 21 ], anti-diabetic effects [ 22 , 23 ], anti-hyperlipidemic effects [ 22 ], antioxidant effects [ 18 , 24 ], prevention in cardiovascular diseases [ 22 ], anti-cancer effects [ 25 ], etc.…”

Section: Introductionmentioning

confidence: 99%

The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin

Chen

Lin

et al. 2021

Molecules

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Cordycepin is an adenosine derivative isolated from Cordyceps sinensis, which has been used as an herbal complementary and alternative medicine with various biological activities. The general anti-cancer mechanisms of cordycepin are regulated by the adenosine A3 receptor, epidermal growth factor receptor (EGFR), mitogen-activated protein kinases (MAPKs), and glycogen synthase kinase (GSK)-3β, leading to cell cycle arrest or apoptosis. Notably, cordycepin also induces autophagy to trigger cell death, inhibits tumor metastasis, and modulates the immune system. Since the dysregulation of autophagy is associated with cancers and neuron, immune, and kidney diseases, cordycepin is considered an alternative treatment because of the involvement of cordycepin in autophagic signaling. However, the profound mechanism of autophagy induction by cordycepin has never been reviewed in detail. Therefore, in this article, we reviewed the anti-cancer and health-promoting effects of cordycepin in the neurons, kidneys, and the immune system through diverse mechanisms, including autophagy induction. We also suggest that formulation changes for cordycepin could enhance its bioactivity and bioavailability and lower its toxicity for future applications. A comprehensive understanding of the autophagy mechanism would provide novel mechanistic insight into the anti-cancer and health-promoting effects of cordycepin.

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“…Other herbal and mushroom supplements that have promising effects to improve post-exercise recovery are Zingiber officinale [ 116 ], Zingiber officinale + Bixa orellana L . [ 117 ], Rhodiola rosea [ 118 ], Cordyceps militaris [ 119 ], and Rhodiola rosea + Cordyceps sinensis [ 120 ]. A root extract that warrants special attention is Withania somnifera (most known as ashwagandha) given some research have found ergogenic effects in athletic [ 121 , 122 ] and physically active individuals [ 123 ].…”

Section: Resultsmentioning

confidence: 99%

The 4R’s Framework of Nutritional Strategies for Post-Exercise Recovery: A Review with Emphasis on New Generation of Carbohydrates

Bonilla

Pérez-Idárraga

Odriozola-Martínez

et al. 2020

IJERPH

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Post-exercise recovery is a broad term that refers to the restoration of training capacity. After training or competition, there is fatigue accumulation and a reduction in sports performance. In the hours and days following training, the body recovers and performance is expected to return to normal or improve. ScienceDirect, PubMed/MEDLINE, and Google Scholar databases were reviewed to identify studies and position declarations examining the relationship between nutrition and sports recovery. As an evidence-based framework, a 4R’s approach to optimizing post-exercise recovery was identified: (i) Rehydration—a fundamental process that will depend on the athlete, environment and sports event; (ii) Refuel—the consumption of carbohydrates is not only important to replenish the glycogen reserves but also to contribute to the energy requirements for the immune system and tissue reparation. Several bioengineered carbohydrates were discussed but further research is needed; (iii) Repair—post-exercise ingestion of high-quality protein and creatine monohydrate benefit the tissue growth and repair; and (iv) Rest—pre-sleep nutrition has a restorative effect that facilitates the recovery of the musculoskeletal, endocrine, immune, and nervous systems. Nutritional consultancy based on the 4R’s is important for the wise stewardship of the hydration, feeding, and supplementation strategies to achieve a timely recovery.

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Anti‐inflammatory effects of cordycepin: A review

Cited by 54 publications

References 108 publications

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin

The 4R’s Framework of Nutritional Strategies for Post-Exercise Recovery: A Review with Emphasis on New Generation of Carbohydrates

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