Cordycepin alleviates airway hyperreactivity in a murine model of asthma by attenuating the inflammatory process

Yang, Xiaofeng; Li, Yanxiang; He, Yongqing; Li, Tingting; Wang, Weirong; Zhang, Jiye; Wei, Jiangtao; Deng, Yong; Lin, Rong

doi:10.1016/j.intimp.2015.04.017

Cited by 40 publications

(30 citation statements)

References 41 publications

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“…Multiple biological activities of Cordycepin have been shown to include antiviral, antifungal, antiinflammatory, antihyperglycemic, and antiatherosclerotic activities. Specifically, Cordycepin has been reported recently to attenuate the inflammatory process in the Ova-driven asthmatic mice [26]. Since the asthma and ALI share some pathological processes, we think that the anti-ALI effects of CM may partially come from miR-3188 and miR-1321, and partially from Cordycepin.…”

Section: Discussionmentioning

confidence: 90%

Cordyceps Militaris Alleviates Severity of Murine Acute Lung Injury Through miRNAs-Mediated CXCR2 Inhibition

Liu

Tang²,

Huang³

et al. 2015

Cell Physiol Biochem

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Background/Aims: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are lethal diseases in humans, and the current treatments have limited therapeutic effects. Cordyceps militaris (CM) is a caterpillar-grown traditional medicinal mushroom, and has been used as a natural invigorant for longevity, endurance, and vitality in China. Recently, purified extracts from CM have been shown to have beneficial effects on various diseases including cancer. Nevertheless, a role of CM in ALI has not been examined previously. Methods: Here, we used a bleomycin-induced ALI model to study the effects of CM on the severity of ALI in mice. The levels of CXCR2, a receptor for Interleukin 8 (IL-8) in pulmonary microvascular endothelial cells, were examined in different experimental groups. The levels of microRNA (miR)-1321 and miR-3188 were also examined in lung samples and in CM. Adeno-associated viruses carrying miR-1321 and miR-3188 were injected into bleomycin-treated mice for evaluation their effects on the severity of ALI. Results: CM treatment significantly alleviated the severity of bleomycin-induced ALI in mice. The increases in lung CXCR2 by bleomycin were significantly reduced by CM at protein level, but not at mRNA level. CM contained high levels of 2 miRNAs (miR-1321 and miR-3188) that target 3'-UTR of CXCR2 mRNA to inhibit its expression. Overexpression of miR-1321 and miR-3188 in mouse lung through AAV-mediated gene therapy mimicked the effects of CM. Conclusion: CM may alleviate severity of murine ALI through miRNAs-mediated CXCR2 inhibition.

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Section: Discussionmentioning

confidence: 90%

Cordyceps Militaris Alleviates Severity of Murine Acute Lung Injury Through miRNAs-Mediated CXCR2 Inhibition

Liu

Tang²,

Huang³

et al. 2015

Cell Physiol Biochem

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“…Cordycepin has been considered as an effective antioxidative agent with protective effects on respiratory system (14), nervous system (15), endocrine system (16), and tumor metastasis (12, 17, 18). Based on the characteristics of cordycepin, we hypothesized that cordycepin might also have effect on cartilage metabolism.…”

Section: Discussionmentioning

confidence: 99%

Cordycepin inhibits chondrocyte hypertrophy of mesenchymal stem cells through PI3K/Bapx1 and Notch signaling pathway

Cao¹,

Dou

et al. 2016

BMB Reports

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Mesenchymal stem cells (MSCs) are widely used in cartilage tissue engineering to repair articular cartilage defects. However, hypertrophy of chondrocytes derived from MSCs might hinder the stabilization of hyaline cartilage. Thus, it is very important to find a suitable way to maintain the chondrogenic phenotype of chondrocytes. It has been reported that cordycepin has anti-inflammatory and anti-tumor functions. However, the role of cordycepin in chondrocyte hypertrophy remains unclear. Therefore, the objective of this study was to determine the effect of cordycepin on chondrogenesis and chondrocyte hypertrophy in MSCs and ATDC5 cells. Cordycepin upregulated chondrogenic markers including Sox9 and collagen type II while down-regulated hypertrophic markers including Runx2 and collagen type X. Further exploration showed that cordycepin promoted chondrogenesis through inhibiting Nrf2 while activating BMP signaling. Besides, cordycepin suppressed chondrocyte hypertrophy through PI3K/Bapx1 pathway and Notch signaling. Our results indicated cordycepin had the potential to maintain chondrocyte phenotype and reconstruct engineered cartilage. [BMB Reports 2016; 49(10): 548-553]

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“…The procedures described above for the adhesion group were repeated and 10 mg/kg cordycepin (product number C 3394; Sigma-Aldrich Corp., St. Louis, MO, USA) single dose diluted with 0.9% sodium chloride to 1 mL was administered intraperitoneally. [15,16] After 15 days, all animals were humanely sacrificed via cardiac blood withdrawal under anesthesia. Next, a U-shaped incision was created in each abdomen.…”

Section: Methodsmentioning

confidence: 99%

Cordycepin prevents postoperative formation of intra-abdominal adhesions in a rat model: An experimental study

Arslan

Zeytun²,

Basuguy³

et al. 2016

Ulus Travma Acil Cerrahi Derg

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Cordycepin alleviates airway hyperreactivity in a murine model of asthma by attenuating the inflammatory process

Cited by 40 publications

References 41 publications

Cordyceps Militaris Alleviates Severity of Murine Acute Lung Injury Through miRNAs-Mediated CXCR2 Inhibition

Cordyceps Militaris Alleviates Severity of Murine Acute Lung Injury Through miRNAs-Mediated CXCR2 Inhibition

Cordycepin inhibits chondrocyte hypertrophy of mesenchymal stem cells through PI3K/Bapx1 and Notch signaling pathway

Cordycepin prevents postoperative formation of intra-abdominal adhesions in a rat model: An experimental study

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