Cord serum adiponectin is positively related to postnatal body mass index gain

Nakano, Yukiko; Itabashi, Kazuo; Nagahara, Kunihiko; Sakurai, Motoichiro; Aizawa, Madoka; Dobashi, Kazushige; Mizuno, Katsumi; Tanaka, Daisuke

doi:10.1111/j.1442-200x.2011.03521.x

Cited by 10 publications

(15 citation statements)

References 22 publications

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“…Nakano et al (17) found that adiponectin levels in cord serum significantly predict body mass index (BMI) z-score gains from birth to 3 years of age in Japanese infants; however, when only the first 6 months were analysed, it was found that adiponectin levels do not predict postnatal BMI z-score gains, a finding that suggests that energy intake influenced by breast feeding and leptin levels may be stronger factors that affect changes in BMI z-scores than adiponectin levels during this period. Meanwhile, Mazaki-Tovi et al (13) reported that adiponectin concentrations negatively correlate with weight and BMI at one year of age, and that leptin concentrations positively correlate with weight and size at one year, suggesting the role of both adipokines in postnatal growth.…”

Section: Discussionmentioning

confidence: 99%

Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns

Treviño-Garza

Estrada-Zúñiga

Mancillas-Adame

et al. 2016

Jcrpe

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Objective:Most adipose tissue programming is realized in early life. Also, the postnatal three months, rather than the later phases of infancy, may be more relevant in the development of an adverse cardiometabolic risk profile. The adipokines phenotype, as a predictor of early-life weight gain, has been recently explored in cord blood. To determine whether in addition to leptin levels in cord samples, adiponectin, interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), resistin, plasminogen activator inhibitor-1 (PAI-1), and tumor necrosis factor alpha (TNF-α) levels improve weight gain prediction during the first three months of life.Methods:Adiponectin, IL-6, MCP-1, leptin, resistin, PAI-1, and TNF-α were measured by multiplex immunoassay in a subsample of 86 healthy term newborns.Results:Leptin levels significantly predicted weight gain at 3 months of follow-up (r2=0.09, p=0.006). In the multivariate analysis, including additional adipokines in the model, stepwise or all at once, did not increase the prediction of weight gain after the first three months of life.Conclusion:Adding adiponectin, IL-6, MCP-1, resistin, PAI-1, and TNF-α to the prediction model of weight gain in healthy newborns did not prove to be useful. It is probable that their relative contribution to weight gain is not important. Only leptin was relevant as a predictor of weight gain at the 3-month endpoint.

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Section: Discussionmentioning

confidence: 99%

Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns

Treviño-Garza

Estrada-Zúñiga

Mancillas-Adame

et al. 2016

Jcrpe

View full text Add to dashboard Cite

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“…Previous longitudinal investigations have been based on cord blood or maternal levels of adipokines during pregnancy . While these concentrations were impacted by placental production, our dried blood spot concentrations are not as both adiponectin and leptin have short half‐lives .…”

Section: Discussionmentioning

confidence: 80%

“…Another study found no associations with rapid infant weight gain at 3 months ( n = 340) with respect to maternal levels of adiponectin measured by fasting serum taken at time of oral glucose tolerance test regardless of whether the pregnancy was complicated by gestational diabetes . Among 56 Japanese infants, cord serum adiponectin levels were associated with weight gain from birth to 3 years of age but not with BMI z‐scores at cross‐sectional time points of 6, 12, and 36 months . One study made similar observations with more direct measures of adiposity .…”

Section: Discussionmentioning

confidence: 92%

“…Lower weight gain in infancy in relation to cord blood leptin has also been observed . There have been mixed results observed for adiponectin, although some reported positive associations with adiposity measures …”

Section: Introductionmentioning

confidence: 97%

“…Studies evaluating cord blood adipokine concentrations of adiponectin and/or leptin with childhood growth used varying measures of adiposity and included children of different ages . Studies have suggested that cord blood leptin levels are inversely associated with weight at later age, particularly between 2 and 4 years, with weaker associations at older age .…”

Section: Introductionmentioning

confidence: 99%

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Newborn adipokines and early childhood growth

Yeung

Sundaram

Xie³

et al. 2018

Pediatric Obesity

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Maternal diet quality during pregnancy is associated with biomarkers of metabolic risk among male offspring

et al. 2021

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Aims/hypothesis Limited data exist on the association between maternal diet quality during pregnancy and metabolic traits in offspring during early childhood, which is a sensitive period for risk of obesity-related disorders later in life. We aimed to examine the association of maternal diet quality, as indicated by the Healthy Eating Index-2010 (HEI), in pregnancy with offspring metabolic biomarkers and body composition at age 4-7 years. Methods We used data from 761 mother-offspring pairs from the Healthy Start study to examine sex-specific associations of HEI >57 vs ≤57 with offspring fasting glucose, leptin, cholesterol, HDL, LDL, percentage fat mass, BMI z score and log-transformed insulin, 1/insulin, HOMA-IR, adiponectin, triacylglycerols, triacylglycerols:HDL, fat mass, and sum of skinfolds. Multivariable linear regression models accounted for maternal race/ethnicity, age, education, smoking habits during pregnancy and physical activity, and child's age. Results During pregnancy, mean (SD) HEI score was 55.0 (13.3), and 43.0% had an HEI score >57. Among boys, there was an inverse association of maternal HEI with offspring glucose, insulin, HOMA-IR and adiponectin. For instance, maternal HEI >57 was associated with lower fasting glucose (−0.11; 95% CI −0.20, −0.02 mmol/l), and lower concentrations of: insulin by 15.3% (95% CI −24.6, −5.0), HOMA-IR by 16.3% (95% CI −25.7, −5.6) and adiponectin by 9.3% (95% CI −16.1, −2.0). Among girls, there was an inverse association of maternal HEI with insulin and a positive association with LDL. However, following covariate adjustment, all estimates among girls were attenuated to the null. Conclusions/interpretation Greater compliance with the USA Dietary Guidelines via the HEI may improve the maternal-fetal milieu and decrease susceptibility for poor metabolic health among offspring, particularly boys. Future studies are warranted to confirm these associations and determine the underlying mechanisms.

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Cord serum adiponectin is positively related to postnatal body mass index gain

Abstract: Birthweight SD score, gestational age, and cord serum adiponectin levels are significant predictors of BMI Z-score gain from birth to 3 years of age in Japanese infants.

Cited by 10 publications

References 22 publications

Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns

Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns

Newborn adipokines and early childhood growth

Maternal diet quality during pregnancy is associated with biomarkers of metabolic risk among male offspring

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