Cord Dorsum Potentials Evoked by Electroacupuncture Applied to the Hind Limbs of Rats

Abstract

The longitudinal distribution of the cord dorsum potentials (CDPs) produced by electroacupuncture (EA) stimulation at acupuncture points (APs) located on the hind limbs of rats was analyzed in this study. Single electrical pulses (0.05 ms, 1 Hz) applied to the bladder (BL) and the gallbladder (GB) APs produced CDPs on several spinal segments and were composed of the following four components: an afferent volley, two negative components (N1 and N2), and one positive component (P wave). The larger evoked CDPs differed in their rostrocaudal distributions depending on the stimulated AP site, with those evoked by GB32-33 (at L3) and GB36-37 (at L4) being more caudal than those generated by BL58-59 (at L5) and BL37-38 (at L6). The CDPs produced by stimulating nonacupoints (NAPs) showed similar components and rostrocaudal distributions that were smaller in amplitude than those evoked by stimulating APs. The CDPs produced by stimulating NAPs located on a meridian acupuncture area were similar in amplitude and longitudinal distribution to those produced by stimulating APs. Our results suggest that the specificity of EA stimulation for CDPs responses is mainly related to an activation of meridian pathways associated with peripheral nerve routes rather than to a restricted point specificity of APs.

Electro‐acupuncture and its combination with adult stem cell transplantation for spinal cord injury treatment: A summary of current laboratory findings and a review of literature

“…53 However, the mechanisms underlying these effects are unclear. GV-EA induces the depolarization of neurons, 54,55 thus leading to the opening of L-type voltage-gated Ca 2+ channels (L-VGCC) and Ca 2+ influx; this process activates calcium/calmodulin-dependent protein kinase (αCaMKII) signaling and the synthesis and secretion of neurotrophic factor (e.g., NT-3). 55 Thus, GV-EA may directly stimulate the afferent nerve fiber endings of the meningeal branch of the SC in adjacent segments and induce the release of CGRP by DRG neurons into the SC.…”

Needling Interventions for Sciatica: Choosing Methods Based on Neuropathic Pain Mechanisms—A Scoping Review

“…Importantly, GABA B receptors are not susceptible to the CL− dysregulation that occurs following nerve injury. A recent study demonstrated that electroacupuncture applied within a particular lumbosacral dermatome, synchronously activates DHN that are interconnected in a rostro-caudal manner across multiple spinal segments [ 115 ]. Evidence suggests that presynaptic inhibition is enhanced by increasing the synchronization between pairs of evoked DHN, allowing better modulation of arriving afferent inputs [ 116 ].…”

The distribution of spinal evoked potentials across dorsal surface in conditions of dorsal roots transection

“…потенциалов поперек спинного мозга в условиях стимуляции целых и перерезанных дорсальных корешков ПДП СМ является интегральным потенциа-лом, который включает в себя ряд суммарных ВПСП нейрональных пулов, возбуждение к которым прихо-дит по афферентным волокнам с определенной ско-рости проведения [8]. Первый негативный (N 1 ) ком-понент (направлен вверх относительно базиса на рис.…”

“…Взаимодействие этих факторов приводит к тому, что в области сег-мента L 5 проявляется наиболее высокоамплитудный N 1 -компонент ПДП, связанный с активацией волокон группы А β . Следует отметить, что клетки данного компонента формируют быстрые восходящие к верх-ним шейным отделам и головному мозгу нервные тракты [6,8] и не участвуют в повторных межсег-ментарных взаимодействиях (ВТ на рис. 3).…”