Cord blood revelations—The importance of being a first born girl, big, on time and to a young mother!

McGuckin, Colin; Basford, Christina; Hanger, K.; Habibollah, Saba; Forraz, Nico

doi:10.1016/j.earlhumdev.2007.09.001

Cited by 37 publications

(48 citation statements)

References 27 publications

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“…Hertz-Picciotto et al (2002) have assessed the association between air pollution and lymphocyte immunophenotype distributions in two districts in the Czech Republic; that study found that maternal age was positively associated with the percentage of B-lymphocytes-and that parity was associated with CD3 + T-lymphocytes percentages-in cord blood samples. Our results did not support the previously reported inverse relationship between umbilical cord blood total nucleated cell levels and either mother's age or obstetric history (McGuckin et al, 2007). We have shown that CD8 + T-lymphocytes were significantly higher in children from smoking women compared to non-smokers.…”

Section: Discussioncontrasting

confidence: 99%

Dynamics of lymphocyte subsets in children living in an area polluted by polychlorinated biphenyls

Horváthová¹,

Jahnová²,

Palkovičová³

et al. 2011

Journal of Immunotoxicology

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Section: Discussioncontrasting

confidence: 99%

Dynamics of lymphocyte subsets in children living in an area polluted by polychlorinated biphenyls

Horváthová¹,

Jahnová²,

Palkovičová³

et al. 2011

Journal of Immunotoxicology

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“…Maternal age but not parity also influenced the APC cytokine responses upon TLR stimulation, such that CBMC of offspring of younger mothers exhibited an increased ability to respond to TLR3, 4 and 9 ligands. These data are in agreement with published data on African [23] and Caucasian [45] women and suggest that maternal age and obstetric history may influence foetal/neonatal immune parameters.…”

Section: Discussionsupporting

confidence: 92%

Plasmodium falciparum exposure in utero, maternal age and parity influence the innate activation of foetal antigen presenting cells

Fiévet

Varani

Ibitokou

et al. 2009

Malar J

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BackgroundMalaria in pregnancy is associated with immunological abnormalities in the newborns, such as hampered T-helper 1 responses and increased T-regulatory responses, while the effect of maternal Plasmodium falciparum infection on foetal innate immunity is still controversial.Materials and methodsThe immunophenotype and cytokine release by dendritic cells (DC) and monocytes were evaluated in cord blood from 59 Beninese women with or without malaria infection by using flow cytometry.ResultsAccumulation of malaria pigment in placenta was associated with a partial maturation of cord blood myeloid and plasmacytoid DC, as reflected by an up-regulated expression of the major histocompatibility complex class II molecules, but not CD86 molecules. Cells of newborns of mothers with malaria pigment in their placenta also exhibited significantly increased cytokine responses upon TLR9 stimulation. In addition, maternal age and parity influenced the absolute numbers and activation status of cord blood antigen-presenting cells. Lastly, maternal age, but not parity, influenced TLR3, 4 and 9 responses in cord blood cells.DiscussionOur findings support the view that placental parasitization, as indicated by the presence of malaria pigment in placental leukocytes, is significantly associated with partial maturation of different DC subsets and also to slightly increased responses to TLR9 ligand in cord blood. Additionally, other factors, such as maternal age and parity should be taken into consideration when analysing foetal/neonatal innate immune responses.ConclusionThese data advocate a possible mechanism by which PAM may modulate foetal/neonatal innate immunity.

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“…(28) Although there are many beneits to using UCB for transplantation there is one major limitation: the TNC count and cell number recoverable from a single unit. This is affected by unit size, maternal factors such as number of previous pregnancies and age of mother (30), limited volumes available from each sample, but not least the processing method used. Together, these factors highlight the need to make processing as eficient as possible (31) to make UCBB a real option.…”

Section: Ucb-scsmentioning

confidence: 99%

Application of Umbilical Cord Blood Stem Cells in Regenerative Medicine

Meiliana

Wijaya

2014

Indones Biomed J

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BACKGROUND: Since the first umbilical cord blood (UCB) transplant, performed 25 years ago, UCB banks have been established worldwide for the collection and cryopreservation of UCB for autologous and allogeneic transplants.CONTENT: Much has been learned in a relatively short time on the properties of UCB hematopoietic progenitors and their clinical application. More interestingly, non-hematopoietic stem cells have been isolated from UCB. These cells can be grown and differentiated into various tissues including bone, cartilage, liver, pancreas, nerve, muscle and so on. The non-hematopoietic stem cells have an advantage over other sources of stem cells, such as embryonic stem cells or induced pluripotent stem cells, because their supply is unlimited, they can be used in autologous or allogeneic situations, they need minimal manipulation and they raise no ethical concerns. Future studies will test the potential of UCB cells for the treatment of several diseases including, among other possibilities, diabetes, arthritis, burns, neurological disorder and myocardial infarction.SUMMARY: In addition to hematopoietic stem cells, UCB contain a large number of non-hematopoietic stem cells. In the absence of ethical concern, the unlimited supply of UCB cells explains the increasing interest of using UCB for developing regenerative medicine.KEYWORDS: UCB, transplantation, UCB bank, HSC, MSC, CD34, CD133, VSEL

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Cord blood revelations—The importance of being a first born girl, big, on time and to a young mother!

Cited by 37 publications

References 27 publications

Dynamics of lymphocyte subsets in children living in an area polluted by polychlorinated biphenyls

Dynamics of lymphocyte subsets in children living in an area polluted by polychlorinated biphenyls

Plasmodium falciparum exposure in utero, maternal age and parity influence the innate activation of foetal antigen presenting cells

Application of Umbilical Cord Blood Stem Cells in Regenerative Medicine

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