Cord blood IGE versus family history as atopic predictors in the newborn

Predictors of cord blood IgE levels in children at risk for asthma and atopy

“…Although many studies have reported an association between family history of atopic disease or asthma and cord blood IgE levels, 24,25,27,[31][32][33][34][35][36][37] fewer studies have investigated the association between maternal total serum IgE levels and cord blood IgE levels, 24,34,35,38,39 and only 2 have specifically examined the relationship between objective measures of maternal atopy, such as allergen-specific IgE levels and cord blood IgE levels. 25,34 In children not selected on the basis of parental history of atopy, a positive result on maternal radioallergosorbent multiantigen screening 25 and maternal sensitization to dog allergen 34 have each been associated with cord blood IgE levels.…”

Cord blood‐IgE as risk factor and predictor for atopic diseases

“…It can be argued that a substantial improvement in laboratory methods and blood sampling techniques explains the transition from a positive evaluation of CB-IgE as predictor of atopic diseases in the early paper of Hamburger et al 1974 [1] and subsequently [2][3][4][5][6][7][8][9][10] to a negative point of view, starting with a paper by Merret et al 1988 [11], followed by many others [12][13][14][15][16][17]. An unsolved question is the IgA control for maternal blood contamination.…”

“…Of course, some misclassifications cannot be totally excluded. A more important point is the great variation in the definition of atopic outcomes between the different studies: Rivas et al [17] '... looked for any probable atopic diseases (recurrent wheezing, immediate food reactions and eczema)' as atopic outcome. Hide et al [14] diagnosed a definite atopy, when there is a positive skin-prick test result in addition to typical atopic symptoms.…”

Maternal allergy influences the proliferation of neonatal T cells expressing CCR4, CXCR5 or CD103

“…A positive family history is considered to be an important risk factor for the development of atopic disease [42] and hence a useful early marker [43]. Elevated cord blood IgE has likewise been considered to predict subsequent development of allergy [44].…”