Predictors of cord blood IgE levels in children at risk for asthma and atopy

Scirica, Christina V.; Gold, Diane R.; Ryan, Louise; Abulkerim, Hassen; Celedón, Juan C.; Platts-Mills, Thomas A.E.; Naccara, L.; Weiss, Scott T.; Litonjua, Augusto A.

doi:10.1016/j.jaci.2006.09.002

Cited by 74 publications

(76 citation statements)

References 51 publications

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“…Maternal IgE has been strongly linked to cord blood, infant, and child IgE levels and the development of childhood allergies (24)(25)(26). Given the preponderance of studies and prevailing wisdom that allergies are protective against childhood leukemias, it is somewhat incongruous that case mothers exhibited higher IgE levels than control mothers in our study, as higher IgE levels in case mothers should impart a higher risk for allergies in cases.…”

Section: Cancer Epidemiol Biomarkers Prev 2009;18(8) August 2009mentioning

confidence: 64%

“…It is possible that a threshold effect may exist, which could explain at least partially the lack of association between maternal total IgE (as a proxy for maternal immune status) and childhood ALL among non-Hispanic Whites. Another study reported that neonatal cord blood IgE, a predictor of atopy, is higher among Hispanics compared to non-Hispanic Whites, independent of two other predictors of cord blood IgE, maternal total IgE level and socioeconomic status (24). This suggests that genetic differences may also contribute to the disparate results observed between Hispanics and non-Hispanic Whites.…”

Section: Schaub Et Al Reported Lower Expression Of Foxp3 and Lower Lmentioning

confidence: 99%

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Maternal Immunoglobulin E and Childhood Leukemia

Chang

Buffler²,

Metayer³

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Childhood leukemia, particularly acute lymphoblastic leukemia (ALL), has long been hypothesized to be affected by abnormal immune responses to microbial challenges stemming from a lack of immune modulation in early childhood. Studies of allergies suggest that a child's immune development may be modulated by maternal immune status. We conducted a study to explore the relationship between maternal immunoglobulin E (IgE) and childhood leukemia and to investigate whether maternal immune status can influence childhood leukemia risk. Serum total and specific IgE (respiratory and food) were measured in biological mothers of 352 children (193 healthy controls and 159 leukemia cases, including 139 ALL cases) ages <8 years who were enrolled in the Northern California Childhood Leukemia Study. Odds ratios associated with maternal IgE were calculated using unconditional logistic regression adjusted for child's age, sex, race/ethnicity, and annual household income. A positive association between childhood leukemia or ALL and elevated levels of maternal serum total IgE was observed, especially among Hispanics. In addition, a positive association was observed between childhood leukemia or ALL and maternal respiratory or food IgE status. These results suggest that maternal immune function may play a crucial role in the etiology of childhood leukemia, although additional studies need to be conducted to confirm the results of this study and provide a perspective on mechanisms.

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Section: Cancer Epidemiol Biomarkers Prev 2009;18(8) August 2009mentioning

confidence: 64%

Section: Schaub Et Al Reported Lower Expression Of Foxp3 and Lower Lmentioning

confidence: 99%

Maternal Immunoglobulin E and Childhood Leukemia

Chang

Buffler²,

Metayer³

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…Clinical data in plasma samples of AD patients AD is very common in children, typically before the age of 5 (Scirica et al, 2007). Therefore, the focus of this investigation is on AD in young children.…”

Section: Resultsmentioning

confidence: 99%

“…AD commonly occurs in infancy and early childhood, but can also start or persist in adulthood (Abramotiv, 2005;Scirica et al, 2007). The pathophysiology of AD includes a disturbed skin barrier function, frequent allergic responses to allergens, defects in the antimicrobial immune defense, and a genetic predisposition.…”

Section: Introductionmentioning

confidence: 99%

Glycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers

et al. 2008

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Atopic dermatitis (AD) is an inflammatory skin disorder that is both uncomfortable and distressing to patients, and its prevalence has been steadily increasing. It is obvious that the identification of efficient markers of AD in plasma would offer the possibility of effective diagnosis, prevention, and treatment strategies. In this study, a proteomic approach was used to analyze plasma glycoproteins from both children with AD and healthy child donors. Several protein spots showing significant quantitative changes in the AD patients were identified. Through sequential studies, it was confirmed that CD5L and ApoE were significantly up-regulated or down-regulated, respectively, in the plasma from AD patients compared with that from healthy donors. In addition, we suggest that the up-regulated CD5L in AD patients causes eosinophilia by inhibiting apoptosis or promoting the proliferation of eosinophils either in combination with or without IL-5. The glycoproteomic data in this study provides clues to understanding the mechanism of atopic alterations in plasma and suggests AD-related proteins can be used as candidate markers for AD.

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“…ThereareseveralfactorsthatmayinfluenceIgElevelsinthefetus.Amongothers,ithasbeenproposedthat atopyinparentsandcloserelativespresagesasignificant increaseintheIgElevels,whichcouldbefollowedbyan increased incidence of atopic diseases during infancy. 15 Most authors point to the presence of atopic diseases, particularly in the mother, as a key factor contributing to elevated levels of IgE in umbilical cord blood. However,theinfluenceofmaternalallergenexposureresultinginpre-orpostnatalallergentransferandtheimpact on developing immune responses of the fetus remains controversial.…”

mentioning

confidence: 99%

Prenatal latex sensitization in patients with spina bifida: a pilot study

Boettcher

Goettler

Eschenburg

et al. 2014

PED

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Object Patients with spina bifida are particularly vulnerable to developing immunoglobulin E (IgE)–mediated latex sensitization. Even though many risk factors leading to latex allergy in these patients have been described, it is still unclear whether the increased prevalence of latex sensitization is disease associated or due to the procedures used to treat spina bifida. The aim of this study was to assess prenatal latex sensitization in patients with spina bifida by examining IgE levels in umbilical cord blood. Methods Patients with spina bifida and matched healthy infants were recruited from the University Medical Center Hamburg-Eppendorf and Children's Hospital Altona. Latex-specific and total IgE were assessed in umbilical cord blood using ImmunoCAP testing to evaluate the degree of prenatal latex sensitization. Results Twenty-two subjects, 10 with spina bifida and 12 healthy individuals, were included. Subjects were selected after matching for sex, gestational age, weight, parental allergy profile, number of prenatal examinations, and utilization of latex tools during pregnancy (propensity score estimates, p = 0.36). In patients with spina bifida, latex-specific and total IgE levels were significantly higher than those in healthy individuals (p = 0.001). After normalization to total IgE, latex-specific IgE levels were higher, yet not significantly increased (p = 0.085). Conclusions Perinatally, there is a significant augmentation of total and latex-specific IgE in patients with spina bifida. After correcting for total IgE, latex-specific IgE was increased, yet not significantly higher than in matched, healthy controls. This pilot study gives novel insights in the immunological reactions related to spina bifida. The increased latex-specific IgE levels could possibly be associated with the occurrence of a latex allergy in the future.

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Predictors of cord blood IgE levels in children at risk for asthma and atopy

Cited by 74 publications

References 51 publications

Maternal Immunoglobulin E and Childhood Leukemia

Maternal Immunoglobulin E and Childhood Leukemia

Glycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers

Prenatal latex sensitization in patients with spina bifida: a pilot study

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