Cord Blood Adiponectin and Visfatin Concentrations in relation to Oxidative Stress Markers in Neonates Exposed and Nonexposed <i>In Utero</i> to Tobacco Smoke

Chełchowska, Magdalena; Ambroszkiewicz, Jadwiga; Gajewska, Joanna; Rowicka, Grażyna; Maciejewski, T.; Mazur, James E.

doi:10.1155/2016/4569108

Cited by 4 publications

(5 citation statements)

References 57 publications

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“…In the presented study, we observed that the intensification of oxidative processes dependent on tobacco smoke significantly influenced glutathione homeostasis. Moreover, our research confirmed the adverse effect of smoking on the oxidant status of both mothers and children [13,19,20]. As mentioned above, as a thiol compound, glutathione plays an extremely important role in enzymatic and non-enzymatic reactions for protecting cells against oxidative stress damage induced by cigarette smoking [23].…”

Section: Discussionsupporting

confidence: 81%

“…All newborns, regardless of prenatal tobacco smoke exposure, are particularly susceptible to oxygen damage due to the conditions generating increased production of free radicals with incomplete maturity of antioxidant systems and the high energy demand of rapidly growing tissues [ 16 ]. Elevated levels of oxidative stress markers in the cord blood of infants born to mothers who smoked actively during pregnancy were also documented, suggesting that exposure to tobacco smoke in utero intensifies oxidative stress in newborns [ 13 ]. Here, we have found a close relationship between TOC concentration, cotinine, and glutathione level in the cord blood.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, exposure to tobacco smoke during pregnancy may impair the defense activity of both antioxidant enzymes and small-molecule non-enzymatic antioxidants [ 9 , 10 , 11 ]. We have previous evidence that oxidative marker levels (e.g., TOC—total oxidant capacity, MDA—malondialdehyde, ox-LDL—oxidized low-density lipoprotein) were higher and antioxidant concentrations (e.g., TAC—total antioxidant capacity, vitamins A, E, and adiponectin) were lower in smoking pregnant women than in non-smoking ones [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Influence of Oxidative Stress Generated by Smoking during Pregnancy on Glutathione Status in Mother-Newborn Pairs

Chełchowska¹,

Gajewska²,

Ambroszkiewicz³

et al. 2021

Antioxidants

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Glutathione plays a key role in maintaining a physiological balance between prooxidants and antioxidants in the human body. Therefore, we examined the influence of maternal smoking as a source of oxidative stress measured by total oxidant capacity (TOC) on reduced glutathione (GSH), oxidized glutathione (GSSG), glutathione peroxidase (GPx-3), and reductase (GR) amount in maternal and umbilical cord blood in 110 (45 smoking and 65 non-smoking) mother-newborn pairs. Concentrations of glutathione status markers and TOC were evaluated by competitive inhibition enzyme immunoassay technique. Plasma TOC levels were significantly higher and the GSH/GSSG ratio, which is considered an index of the cell’s redox status, were significantly lower in smoking women and their offspring than in non-smoking pairs. Decreased GR levels were found in smoking mothers and their newborns compared with similar non-smoking groups. Although plasma GPx-3 concentrations were similar in both maternal groups, in the cord blood of newborns exposed to tobacco smoke in utero they were reduced compared with the levels observed in children of tobacco abstinent mothers. Oxidative stress generated by tobacco smoke impairs glutathione homeostasis in both the mother and the newborn. The severity of oxidative processes in the mother co-existing with the reduced potential of antioxidant systems may have a negative effect on the oxidative-antioxidant balance in the newborn.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influence of Oxidative Stress Generated by Smoking during Pregnancy on Glutathione Status in Mother-Newborn Pairs

Chełchowska¹,

Gajewska²,

Ambroszkiewicz³

et al. 2021

Antioxidants

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“…Increased visfatin along with resistin was associated with increased diabetes and cardiovascular risk in obese patients[ 37 ]. In another study, higher visfatin and TOS and lower TAS levels were observed in infants born to mothers who smoked[ 38 ]. Patients with psoriasis were evaluated for the same relationship.…”

Section: Discussionmentioning

confidence: 99%

Relationship between diabetic polyneuropathy, serum visfatin, and oxidative stress biomarkers

Büyükaydın

Güler

Karaaslan

et al. 2020

WJD

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BACKGROUND Diabetic polyneuropathy is a very common complication of diabetes. Numerous studies are available in terms of pathogenesis. But examination methods with low reliability are still not standardized and generally time consuming. High-sensitive, easy-to-access methods are expected. Biochemical markers are one of the subjects of research. We aimed to discover a potential biomarker that can be used for this purpose in patients with diabetes who have not yet developed symptoms of neuropathy. AIM To determine the place and availability of visfatin and thiol-disulfide homeostasis in this disorder. METHODS A total of 392 patients with type 2 diabetes mellitus were included in the study. The polyneuropathy clinical signs were evaluated with the Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire and examination. The biochemical parameters, oxidative stress markers, visfatin, and thiol-disulfide homeostasis were analyzed and correlated with each other and clinical signs. RESULTS Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire with examination scores were correlated with each other and diabetes duration ( P < 0.005). Neuropathy related symptoms were present in 20.7% of the patients, but neuropathy related findings were observed in 43.9% of the patients. Serum glucose, glycated hemoglobin, and visfatin were positively correlated with each other. Also, these parameters were positively correlated with the total oxidative stress index. Total and native thiol was positively correlated with total antioxidant status and negatively with oxidant status. Inversely thiol-disulfide positively correlated with higher glucose and oxidant status and negatively with total antioxidant status ( P < 0.005). There was no correlation between visfatin and thiol-disulphide ( P = 0.092, r = 0.086). However, a significant negative correlation was observed between visfatin and total with native thiol ( P < 0.005, r = -0.338), ( P < 0.005, r = -0.448). CONCLUSION Diagnosis of neuropathy is one of the issues studied in patients with diabetes. Visfatin and thiol-disulfide balance were analyzed for the first time in this study with inspiring results.

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“…It is described that SHS leads to metabolic syndrome in adolescents [106] and children, especially in combination with low intake of vitamin E or omega-3 polyunsaturated fatty acids [107]. Neonates exposed to PTS were shown to have lower levels of adiponectin and higher levels of visfatin, indicating a less beneficial OS profile compared to non-exposed new-borns [108]. In an urban study, adolescents exposed to SHS showed an increase in urinary 15-F 2t -isoprostane, a specific product of lipid peroxidation and biomarker for OS level [109].…”

Section: Oxidative Stressmentioning

confidence: 99%

Influence of Second-Hand Smoke and Prenatal Tobacco Smoke Exposure on Biomarkers, Genetics and Physiological Processes in Children—An Overview in Research Insights of the Last Few Years

Braun

Klingelhöfer

Oremek

et al. 2020

IJERPH

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Children are commonly exposed to second-hand smoke (SHS) in the domestic environment or inside vehicles of smokers. Unfortunately, prenatal tobacco smoke (PTS) exposure is still common, too. SHS is hazardous to the health of smokers and non-smokers, but especially to that of children. SHS and PTS increase the risk for children to develop cancers and can trigger or worsen asthma and allergies, modulate the immune status, and is harmful to lung, heart and blood vessels. Smoking during pregnancy can cause pregnancy complications and poor birth outcomes as well as changes in the development of the foetus. Lately, some of the molecular and genetic mechanisms that cause adverse health effects in children have been identified. In this review, some of the current insights are discussed. In this regard, it has been found in children that SHS and PTS exposure is associated with changes in levels of enzymes, hormones, and expression of genes, micro RNAs, and proteins. PTS and SHS exposure are major elicitors of mechanisms of oxidative stress. Genetic predisposition can compound the health effects of PTS and SHS exposure. Epigenetic effects might influence in utero gene expression and disease susceptibility. Hence, the limitation of domestic and public exposure to SHS as well as PTS exposure has to be in the focus of policymakers and the public in order to save the health of children at an early age. Global substantial smoke-free policies, health communication campaigns, and behavioural interventions are useful and should be mandatory.

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Cord Blood Adiponectin and Visfatin Concentrations in relation to Oxidative Stress Markers in Neonates Exposed and Nonexposed In Utero to Tobacco Smoke

Cited by 4 publications

References 57 publications

Influence of Oxidative Stress Generated by Smoking during Pregnancy on Glutathione Status in Mother-Newborn Pairs

Influence of Oxidative Stress Generated by Smoking during Pregnancy on Glutathione Status in Mother-Newborn Pairs

Relationship between diabetic polyneuropathy, serum visfatin, and oxidative stress biomarkers

Influence of Second-Hand Smoke and Prenatal Tobacco Smoke Exposure on Biomarkers, Genetics and Physiological Processes in Children—An Overview in Research Insights of the Last Few Years

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