Copy number variations and stroke

Colaianni, Valeria; Mazzei, R.; Cavallaro, Sebastiano

doi:10.1007/s10072-016-2658-y

Cited by 11 publications

(10 citation statements)

References 47 publications

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“…This cerebrovascular damage is characterized by brain vessels occlusion or blockage (ischemic stroke), as well as blood vessels rupture (hemorrhagic stroke) 1. Based on the same mechanism of the ischemic stroke with a different period of occurrence, the transient ischemic attack is another type of cerebrovascular accident, with less than 24 hrs of duration 2. Moreover, other classifications or subtypes of these changes are described in the literature, such as subarachnoid hemorrhage, cerebral venous thrombosis, and spinal cord stroke 3.…”

Section: Introductionmentioning

confidence: 99%

<p>Periodontitis As A Risk Factor For Stroke: A Systematic Review And Meta-Analysis</p>

Fagundes¹,

Almeida²,

Vilhena³

et al. 2019

VHRM

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This systematic review and meta-analysis investigate the association between periodontitis and stroke. This review followed the methods established by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. Searches were conducted in five databases and two sources of grey literature. After the selection of the articles, a risk of bias evaluation was performed. Three meta-analyzes were performed: Assessing the overall association between stroke and periodontitis in case–control studies; Ischemic stroke and periodontitis in case–control studies; The association between stroke and periodontitis in cohort studies. Heterogeneity was assessed using the I2 index and the odds ratio was also calculated (p < 0.05). The Grading of Recommendations Assessment, Development and Evaluation (GRADE) was applied to evaluate the level of evidence. 2193 potentially relevant studies were identified, with 10 studies included in qualitative and quantitative analysis. All the articles were considered with low risk of bias and a low level of certainty. The results demonstrated a positive association between both disorders and increased risk for stroke among cohort studies (RR 1.88 [1.55, 2.29], p<0.00001, I2=0%) and for ischemic stroke events in case–control studies (RR 2.72 [2.00, 3.71], p<0.00001, I2= 4%). Periodontitis may represent a risk factor for stroke, especially in ischemic events. However, new studies with a robust design are necessary for a reliable conclusion.

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Section: Introductionmentioning

confidence: 99%

<p>Periodontitis As A Risk Factor For Stroke: A Systematic Review And Meta-Analysis</p>

Fagundes¹,

Almeida²,

Vilhena³

et al. 2019

VHRM

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“…Vale ressaltar que a técnica de microarranjo da DNA tem sido utilizada em pesquisa acadêmica como ferramenta de validação de dados de transcriptoma via RNAseq gerados pelas plataformas de sequenciamento de nova geração (Next Generation Sequencing), as quais apresentam custos cada vez mais acessíveis (KOGENARU et al, 2012). Além dessa aplicação, a demanda por genotipagem para detecção de polimorfismos (especialmente SNPs e CNVs) tem crescido de forma regular (PINTO et al, 2011) especialmente associando tais polimorfismos para o diagnóstico ou predição de fatores de risco em humanos (COLAIANNI et al, 2016).…”

Section: Métodounclassified

“…As sondas consistem de pequenas sequências quimicamente sintetizadas, denominadas de oligonucleotídeos, com tamanho que varia de 25 a 80 pares de bases e imobilizadas na superfície da lâmina (DNA-chip) com o auxílio de tecnologia robótica (CHEUNG;et al, 1999;MILLER;TANG, 2009). O microarranjo de DNA constitui uma das principais técnicas utilizadas para a análise da expressão gênica em larga-escala, sendo bastante difundida devido à necessidade de se monitorar uma grande quantidade de informação gênica gerada pelo sequenciamento de genomas e transcriptomas, com aplicações em diversas áreas de interface com a biologia, como medicina, agropecuária, farmacologia e ciências forenses, entre outras (CHEUNG;et al, 1999;HELLER, 2002;KNAPEN;MILLER;TANG, 2009 Number Variation), tratando-se de um teste rápido para avaliar risco a certas doenças hereditárias ou adquiridas (PINTO et al, 2011) como, por exemplo, propensão a derrames cerebrais (COLAIANNI et al, 2016).…”

Section: Introductionunclassified

Dna Microarray Plataform: Prospection Technological and Scientific Demand

Silva-Junior¹,

Belarmino²,

Benko‐Iseppon³

2018

RGEINTEC

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Palavras-chave: prospecção tecnológica, demanda científica, ácidos nucleicos. Abstract:Microarray is a set of techniques for experiments in Molecular Biology that aims to analyze polymorphism and expression level of transcripts used for the analysis of gene expression in a wide scale with applications in the areas of agronomy, human health, pharmacology, forensic and veterinary, among others. The problem with this set of techniques is that they are executed experimentally and isolated from one another, there being no continuous flow within a single technology allocated in a single platform. The main objective of the research is to carry out a prospecting technology for verification of priority and verification of scientific and projection of Revista GEINTEC-ISSN: 2237-0722. Aracaju/SE. Vol.8, n.2, p.4369-4380, abr/maio/jun -2018 4370 D.O.I.: 10.7198/geintec.v8i2.1152demand in Brazil until the year 2020 in order to verify the feasibility of obtaining a patent as well as the future capacity of commercialization.

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“…Stroke is one of the main diseases accounting for global burden of chronic NCDs [1,2]. Globally 15 million experience strokes annually, out of which one third die and a similar number is left disabled [3].…”

Section: Introductionmentioning

confidence: 99%

Construct validity and reliability of EQ-5D-3L for stroke survivors in a lower middle income setting

et al. 2019

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Introduction Stroke is a leading disease accounting for burden of chronic NCDs especially in lower and lowermiddle income (LMI) settings. Quality of Life (QOL) is considered as an important facet of determination of success of patient management. EQ-5D-3L is a generic QOL tool. It provides an index score amalgamating responses for five descriptive questions and a visual analogue scale (VAS) value. Objectives To assess the validity and reliability of EQ-5D-3L for stroke patients in Sri Lanka, which is a LMI setting. Methods A descriptive cross sectional study was done among 100 stroke survivors among whom 50 each were managed at an ambulatory setting and an inward setting. A second wave of data collection was done for reliability analysis among one half of participants. The validity of EQ-5D-3L was assesses with five a-priori hypotheses. Reliability was assessed with test-retest method and with internal consistency. Non parametric Mann Whitney U test and Spearman correlation coefficients were used in the analysis. Results The EQ-5D index scores had significant positive correlation with SF-36 domain scores (p<0.001). The EQ-5D VAS scores had significant positive correlation with SF-36 domain scores (p<0.01). Index and VAS values of the EQ-5D were proved to be valid in known-group comparison (p<0.001). Participants reporting some kind of impairment for EQ-5D-3L dimensions had lower SF-36 domain scores. All the kappa values in the analysis of test-retest method were significant (p<0.001). For the VAS score, the Spearman correlation coefficient in testreter analysis was 0.993 (p<0.001). Cronbach's alpha value was 0.928. Conclusions and Recommendations EQ-5D-3L questionnaire demonstrates construct validity and is a reliable tool in measuring QOL among stoke survivors in Sri Lanka. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Copy number variations and stroke

Cited by 11 publications

References 47 publications

<p>Periodontitis As A Risk Factor For Stroke: A Systematic Review And Meta-Analysis</p>

<p>Periodontitis As A Risk Factor For Stroke: A Systematic Review And Meta-Analysis</p>

Dna Microarray Plataform: Prospection Technological and Scientific Demand

Construct validity and reliability of EQ-5D-3L for stroke survivors in a lower middle income setting

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