<p>Periodontitis As A Risk Factor For Stroke: A Systematic Review And Meta-Analysis</p>

Abstract

This systematic review and meta-analysis investigate the association between periodontitis and stroke. This review followed the methods established by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. Searches were conducted in five databases and two sources of grey literature. After the selection of the articles, a risk of bias evaluation was performed. Three meta-analyzes were performed: Assessing the overall association between stroke and periodontitis in case–control studies; Ischemic stroke and periodontitis in case–control studies; The association between stroke and periodontitis in cohort studies. Heterogeneity was assessed using the I2 index and the odds ratio was also calculated (p < 0.05). The Grading of Recommendations Assessment, Development and Evaluation (GRADE) was applied to evaluate the level of evidence. 2193 potentially relevant studies were identified, with 10 studies included in qualitative and quantitative analysis. All the articles were considered with low risk of bias and a low level of certainty. The results demonstrated a positive association between both disorders and increased risk for stroke among cohort studies (RR 1.88 [1.55, 2.29], p<0.00001, I2=0%) and for ischemic stroke events in case–control studies (RR 2.72 [2.00, 3.71], p<0.00001, I2= 4%). Periodontitis may represent a risk factor for stroke, especially in ischemic events. However, new studies with a robust design are necessary for a reliable conclusion.

Is periodontitis a risk factor for ischaemic stroke, coronary artery disease and subclinical atherosclerosis? A Mendelian randomization study

“…Observational studies have associated periodontitis with a range of diseases, including cardiovascular disease [ 5 ], Alzheimer's disease [ 13 ], hypertension [ 14 ], and diabetes [ 15 ]. A recent meta-analysis found that individuals with periodontitis had almost two-fold greater risk of stroke, with this effect further pronounced for events of ischaemic origin [ 16 ]. However, observational studies are subject to confounding; for example, those with periodontal disease may have poorer access to healthcare or lower income [ 17 ].…”

Is an Oral Health Status a Predictor of Functional Improvement in Ischemic Stroke Patients Undergoing Comprehensive Rehabilitation Treatment?

“…In recent meta-analyses, authors compared oral health between stroke patients and controls (healthy population). The results indicated that stroke patients had poorer oral health and worse periodontal status [ 8 , 9 , 10 ] as well as less frequent dental attendance behavior than controls [ 11 , 12 ]. Therefore, further research concerning oral health problems after stroke should be conducted, and effective management strategies need to be devised and implemented.…”

Association of Tooth Loss with New-Onset Parkinson’s Disease: A Nationwide Population-Based Cohort Study

“…Periodontitis is the main cause of tooth loss in middle aged and older adults [11]. In previous studies, increased number of tooth loss caused by chronic inflammation due to gingivitis and periodontitis was related to cardiovascular diseases including myocardial infarction, stroke, and long-term mortalities [12][13][14][15][16][17].…”