Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology 2015
DOI: 10.1016/b978-0-12-802508-6.00021-1 View full text |Buy / Rent full text
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Abstract: Interaction networks can be charted by seeking gene pairs that are amplified and/or deleted in tandem, even when located at a distance on the genome. Our experience with radiation hybrid (RH) panels, a library of cell clones that have been used for genetic mapping, have shown this tool can pinpoint statistically significant patterns of co-inherited gene pairs. In fact, we were able to identify gene pairs specifically associated with the mechanism of cell survival at single gene resolution. Further, the RH netw… Show more

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