Complementary human gene interaction maps from radiation hybrids and CRISPRi
Desmond J. Smith
Abstract:The only comprehensive genetic interaction map of the human genome was constructed using increased gene copy number in radiation hybrid (RH) cells. More recently, interactions restricted to essential genes were identified using loss-of-function alleles made by CRISPRi technology. I compared the two maps to understand their similarities and differences. Both maps overlapped significantly with a database of protein-protein interactions. However, interactions in the RH and CRISPRi datasets had no significant over… Show more
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