Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation

Guo, Jing; Wang, Shoubao; Yuan, Tianyi; Wu, Yujie; Yu, Yan; Li, Li; Xu, Xiaona; Gong, Lili; Qin, Hai‐Lin; Fang, Lian-Hua; Du, Guanhua

doi:10.1016/j.atherosclerosis.2013.10.003

Cited by 103 publications

(81 citation statements)

References 29 publications

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“…Anti-inflammatory Attenuated the production of proinflammatory cytokines such as IL-1β, IL-6, and TNF-α [115] .…”

Section: Anti-inflammatorymentioning

confidence: 99%

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Chelidonium majus L. (Greater celandine) – A Review on its Phytochemical and Therapeutic Perspectives

Maji¹,

Banerji²

2015

Int. J. Herb. Med.

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Chelidonium majus L. (Papaveraceae) is a medicinal herb used in various traditional systems of medicine to treat ulcer, cancer, oral infection, liver disorders, chronic bronchitis, asthma, etc. Different parts of this plant contain numerous therapeutically important alkaloidal constituents such as chelidonine, chelerythrine, sanguinarine, berberine and so on. The plant and its active compounds exhibit a wide range of pharmacological activities. The plants has long history of therapeutic use in medicines without any toxic effect. Today it is one of the important components of some pharmaceutical preparations. Consumption of C. majus preparations possesses toxic effects on the liver although the effect becomes controversial with its hepatoprotective effect. Numerous active constituents of C. majus interact with various drug metabolizing enzymes that mimic possible interactions of this herb with the conventional drugs. This review provides detailed phytochemical, pharmacological and toxicological information of C. majus along with mechanisms of action of its various active compounds on different aspects of pharmacology. This review also highlights plausible drug interaction of its various active compounds and the future prospect of this herb.

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“…Anti-inflammatory Attenuated the production of proinflammatory cytokines such as IL-1β, IL-6, and TNF-α [115] .…”

Section: Anti-inflammatorymentioning

confidence: 99%

“…Cardioprotective Inhibited myocardial cells apoptosis via upregulation of Bcl-2 protein, inhibition of caspase-3 activation and Rho/Rho-kinase signalling pathway [115] . Antinephritic Improved renal hemodynamics by changing prostanoid synthesis [94] .…”

Section: Anti-inflammatorymentioning

confidence: 99%

Chelidonium majus L. (Greater celandine) – A Review on its Phytochemical and Therapeutic Perspectives

Maji¹,

Banerji²

2015

Int. J. Herb. Med.

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“…16 MIRI is a complicated process that is associated with various factors and mechanisms, including oxidative damage, necrosis, apoptosis, inflammation, energy metabolism disruption and calcium overload. [17][18][19][20][21] All of these conditions could lead to the apoptosis of heart cells, mitochondrial injury and elevation of levels of cardiac enzymes and inflammation factors. Since 2013, the number of deaths caused by MIRI has increased remarkably, and therefore, the treatment of MIRI is one of the most significant problems that needs to be solved.…”

Section: Introductionmentioning

confidence: 99%

Development of solid lipid nanoparticles containing total flavonoid extract from<em> Dracocephalum moldavica</em> L. and their therapeutic effect against myocardial ischemia–reperfusion injury in rats

Tan¹,

He²,

Wen³

et al. 2017

IJN

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Total flavonoid extract from Dracocephalum moldavica L. (TFDM) contains effective components of D. moldavica L. that have myocardial protective function. However, the cardioprotection function of TFDM is undesirable due to its poor solubility. In order to improve the solubility and efficacy of TFDM, we developed TFDM-loaded solid lipid nanoparticles (TFDM-SLNs) and optimized the formulation of TFDM-SLNs using central composite design and response surface methodology. The physicochemical properties of TFDM-SLNs were characterized, and the pharmacodynamics was investigated using the myocardial ischemia–reperfusion injury model in rats. The nanoparticles of optimal formulation for TFDM-SLNs were spherical in shape with the average particle size of 104.83 nm and had a uniform size distribution with the polydispersity index value of 0.201. TFDM-SLNs also had a negative zeta potential of −28.7 mV to ensure the stability of the TFDM-SLNs emulsion system. The results of pharmacodynamics demonstrated that both TFDM and TFDM-SLN groups afforded myocardial protection, and the protective effect of TFDM-SLNs was significantly superior to that of TFDM alone, based on the infarct area, histopathological examination, cardiac enzyme levels and inflammatory factors in serum. Due to the optimal quality and the better myocardial protective effect, TFDM-SLNs are expected to become a safe and effective nanocarrier for the oral delivery of TFDM.

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“…Не последнюю роль играет воспалительная реакция в ходе ишеми-ческого повреждения тканей [47,49,60,65,70,73, 100] и канцерогенезе [99]. Показано, что структур-ный аналог эхинохрома А плюмбаген (5-гидрокси-2-метил-1,4-нафтохинон) инициирует апоптоз в коло-ниях раковых клеток посредством TNF-α-зависимой экспрессии ЦОГ-2 [99].…”

Section: офтальмологические эффекты препарата гистохром ®unclassified

The cellular and molecular mechanisms providing therapeutic efficiency of gistokhrom

Talalaeva

Сергеевна²,

Zverev

et al. 2017

Rev Clin Pharm Drug Ther

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The review presents the screening of the therapeutic effects of the Russia drug “Histochrome”, active substance of which is quinoid pigment marine - echinochrome A (2,3,5,6,8-pentahydroxy-7-ethyl-1,4-naphthoquinone). Assessing the pharmacological aspects of the drug authors have focused on cellular and molecular mechanisms of action of histochrome. The parallel between echinochrome A pharmacodynamics and its biological effects proves promising directions for expansion of the clinical application of the preparation “Histochrome”. (For citation: Talalaeva OS, Zverev YaF, Bryukhanov VM. The cellular and molecular mechanisms providing therapeutic efficiency of gistokhrom. Reviews on Clinical Pharmacology and Drug Therapy. 2017;15(4):58-68. doi: 10.17816/RCF15458-68).

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Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation

Cited by 103 publications

References 29 publications

Chelidonium majus L. (Greater celandine) – A Review on its Phytochemical and Therapeutic Perspectives

Chelidonium majus L. (Greater celandine) – A Review on its Phytochemical and Therapeutic Perspectives

Development of solid lipid nanoparticles containing total flavonoid extract from<em> Dracocephalum moldavica</em> L. and their therapeutic effect against myocardial ischemia–reperfusion injury in rats

The cellular and molecular mechanisms providing therapeutic efficiency of gistokhrom

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Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation

Cited by 103 publications

References 29 publications

Chelidonium majus L. (Greater celandine) – A Review on its Phytochemical and Therapeutic Perspectives

Chelidonium majus L. (Greater celandine) – A Review on its Phytochemical and Therapeutic Perspectives

Development of solid lipid nanoparticles containing total flavonoid extract from<em> Dracocephalum moldavica</em> L. and their therapeutic effect against myocardial ischemia&ndash;reperfusion injury in rats

The cellular and molecular mechanisms providing therapeutic efficiency of gistokhrom

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Product

Resources

About

Development of solid lipid nanoparticles containing total flavonoid extract from<em> Dracocephalum moldavica</em> L. and their therapeutic effect against myocardial ischemia–reperfusion injury in rats