Coptisine attenuates obesity-related inflammation through LPS/TLR-4-mediated signaling pathway in Syrian golden hamsters

Zou, Zongyao; Hu, Yinran; Ma, Hang; Wang, Yanzhi; He, Kai; Xia, Shuang; Wu, Hao; Xue, Dongfang; Li, Xuegang; Ye, Xiaoli

doi:10.1016/j.fitote.2015.06.005

Cited by 57 publications

(31 citation statements)

References 30 publications

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“…Among the alkaloids, berberine is a main active component of Rhizoma coptidis [34]. The studies found that Rhizoma coptidis can reduce weight, lower lipids [56], reduce lipid synthesis [57], and inhibit adipogenesis [58]. Xie et al [35] found that Rhizoma coptidis (RC) (200 mg/kg) and berberine (200 mg/kg) significantly lowered body and visceral adipose weight, reduced blood glucose and lipid levels, and decreased degradation of dietary polysaccharides in high-fat diet (HFD) mice.…”

Section: Resultsmentioning

confidence: 99%

Herbal Medicine for the Treatment of Obesity: An Overview of Scientific Evidence from 2007 to 2017

Liu

Sun

Yao

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Obesity is a very common global health problem, and it is known to be linked to cardiovascular and cerebrovascular diseases. Western medical treatments for obesity have many drawbacks, including effects on monoamine neurotransmitters and the potential for drug abuse and dependency. The safety of these medications requires improvement. Herbal medicine has been used for treatment of disease for more than 2000 years, and it has proven efficacy. Many studies have confirmed that herbal medicine is effective in the treatment of obesity, but the mechanisms are not clear. This article will discuss the possible effects and mechanisms of herbal medicine treatments for obesity that have been reported in the past decade.

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Section: Resultsmentioning

confidence: 99%

Herbal Medicine for the Treatment of Obesity: An Overview of Scientific Evidence from 2007 to 2017

Liu

Sun

Yao

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…Previous studies showed that coptisine treatment also attenuated the pro-inflammatory cytokines including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α in heart tissue after myocardial ischemia/ reperfusion injury [10]. Meanwhile, coptisine was found to inhibit obesity-related inflammation through LPS/ TLR4-mediated signaling pathway in Syrian golden hamsters [11]. However, the anti-inflammatory effects of coptisine on IL-1β-stimulated chondrocytes have not been reported.…”

Section: Introductionmentioning

confidence: 99%

Coptisine Prevented IL-β-Induced Expression of Inflammatory Mediators in Chondrocytes

Zhou

Liao

et al. 2016

Inflammation

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Interleukin 1β (IL-1β) is a pleiotropic pro-inflammatory cytokine that plays a critical role in the development of osteoarthritis (OA). Coptisine is an isoquinoline alkaloid extracted from Coptidis rhizome and has been reported to possess anti-inflammatory activity. However, the anti-inflammatory effects of coptisine on interleukin-1 beta (IL-1β)-stimulated chondrocytes have not been reported. Therefore, the aim of this study was to investigate the effects of coptisine on IL-1β-induced inflammation in human articular chondrocytes. Our results showed that coptisine greatly inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2), as well as suppressed the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in human OA chondrocytes induced by IL-1β. It also inhibited the expression of matrix metalloproteinase-3 (MMP-3) and MMP-13 in IL-1β-stimulated human OA chondrocytes. Furthermore, coptisine significantly inhibited the IL-1β-induced NF-kB activation in human OA chondrocytes. Taken together, these data suggest that coptisine inhibits the IL-1β-induced inflammatory response by suppressing the NF-kB signaling pathway. Thus, coptisine may be a potential agent in the treatment of OA.

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“…The herbal materials in HVC1, namely Coptidis Rhizoma (CR, rhizome of Coptischinensis ), Scutellariae Radix (SR, radix of Scutellariabaicalensis ), Rhei Rhizoma (RR, rhizome of Rheum officinale ), and Pruni Cortex (PC, cortex of Prunusyedoensis Matsum are used as traditional medicines. The main bioactive compounds of CR are coptisine which improved obesity-related inflammatory response in syrian golden hamsters [18]. CR extract is reported to reduce oxidative stress and cholesterol levels [19] and the bioflavonoids from SR suppress the level of serum lipid [20] and RR possess hypolipidemic effects in hyperlipidemic rat model [21].…”

Section: Introductionmentioning

confidence: 99%

HVC1 ameliorates hyperlipidemia and inflammation in LDLR−/− mice

Cheon

Chung

Lee

et al. 2017

BMC Complement Altern Med

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BackgroundHVC1 consists of Coptidis Rhizoma (dried rhizome of Coptischinensis), Scutellariae Radix (root of Scutellariabaicalensis), Rhei Rhizoma (rhizome of Rheum officinale), and Pruni Cortex (cortex of Prunusyedoensis Matsum). Although the components are known to be effective in various conditions such as inflammation, hypertension, and hypercholesterolemia, there are no reports of the molecular mechanism of its hypolipidemic effects.MethodsWe investigated the hypolipidemic effect of HVC1 in low-density lipoprotein receptor-deficient (LDLR−/−) mice fed a high-cholesterol diet for 13 weeks. Mice were randomized in to 6 groups: ND (normal diet) group, HCD (high-cholesterol diet) group, and treatment groups fed HCD and treated with simvastatin (10 mg/kg, p.o.) or HVC1 (10, 50, or 250 mg/kg, p.o.).ResultsHVC1 regulated the levels of total cholesterol, triglyceride (TG), low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol in mouse serum. In addition, it regulated the transcription level of the peroxisome proliferator-activated receptors (PPARs), sterol regulatory element-binding proteins (SREBP)-2, 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase, lipoprotein lipase (LPL), apolipoprotein B (apo B), liver X receptor (LXR), and inflammatory cytokines (IL-1β, IL-6, and TNF-α). Furthermore, HVC1 activated 5′ adenosine monophosphate-activated protein kinase (AMPK).ConclusionOur results suggest that HVC1 might be effective in preventing high-cholesterol diet-induced hyperlipidemia by regulating the genes involved in cholesterol and lipid metabolism, and inflammatory responses.

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Coptisine attenuates obesity-related inflammation through LPS/TLR-4-mediated signaling pathway in Syrian golden hamsters

Cited by 57 publications

References 30 publications

Herbal Medicine for the Treatment of Obesity: An Overview of Scientific Evidence from 2007 to 2017

Herbal Medicine for the Treatment of Obesity: An Overview of Scientific Evidence from 2007 to 2017

Coptisine Prevented IL-β-Induced Expression of Inflammatory Mediators in Chondrocytes

HVC1 ameliorates hyperlipidemia and inflammation in LDLR−/− mice

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