Copper, Zinc, Manganese, Niacin and Pyridoxine in the Schizophrenias

Pfeiffer, Carl C.; Bacchi, Donna

doi:10.1016/b978-0-08-021533-4.50027-x

Cited by 7 publications

(5 citation statements)

References 38 publications

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“…The significantly low concentration of copper observed in the hypertensive subjects when compared with the control subjects is in consonance with the findings of Asaolu et al [26] but in contrast with Pfeiffer & Mailloux [27] who reported a strong positive correlation between high serum copper and hypertension with the assumption that copper excess might be a strong factor in the aetiology of hypertension. The zinc/copper ratio in the hypertensive subjects was significantly lower than that of the normotensive subjects in this study.…”

Section: Discussionsupporting

confidence: 90%

Atherogenicity, Oxidative Stress, Heavy Metals and Bioelements Status in Hypertensive Nigerians in an Urban Population

Oyewole,

Adeleke,

Taiwo

et al. 2023

AJMAH

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Objectives: This study investigated levels of measured parameters; bio-elements (zinc, copper, selenium, chromium, and manganese), heavy metals (cadmium and lead), oxidative stress biomarkers (vitamin C, Vitamin E, reduced Glutathione-GSH and malondialdehyde-MDA) and lipid profile (cholesterol-CHOL, triglyceride- TG, high-density lipoprotein- HDL, low-density lipoprotein- LDL and VLDL) in primary hypertensive individuals. Materials and Methods: A total of 74 confirmed hypertensive individuals (30 males, 44 females) of 30-55 years (test subjects) and 46 (22males, 24 females) age-matched apparently healthy normotensive individuals (control) were involved in this study. Atomic absorption spectrophotometer was used to determine the concentrations of bio-elements and toxic metals while spectrophotometric methods were used for the concentrations of oxidative stress biomarkers and lipid fractions. Results: Comparative analysis between test and control subjects showed significantly reduced concentrations of vitamins C and E, GSH, the bio-elements, HDL and Zinc/Copper ratio. Significantly elevated concentrations of the toxic metals, MDA, CHOL, TG, LDL, and VLDL, the atherogenic indices- LDL/HDL, TC/HDL, and TG/HDL as well as Cadmium/ Zinc ratio. There was indirect association between the bio-elements and atherogenic lipid fractions but a direct correlation with HDL. Also, negative correlations were observed between the heavy metals and the antioxidants biomolecules. Conclusion: The concentrations of the measured bio-elements, vitamins C and E, GSH and HDL were significantly lower in hypertensive individuals while the levels of heavy metals, cholesterol, TG, LDL and MDA were significantly higher.

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Section: Discussionsupporting

confidence: 90%

Atherogenicity, Oxidative Stress, Heavy Metals and Bioelements Status in Hypertensive Nigerians in an Urban Population

Oyewole,

Adeleke,

Taiwo

et al. 2023

AJMAH

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“…Hsiao et al (1987) have described patients who respond to tricyclic antidepressants having a high correlation among CSF monoamine metabolites (HV A, 5-HIAA, and l\1HPG) both before and after treatment, while in non-responders there is a lack of such a correlation, both before and after. Pfeiffer (1975) postulated that depression is related to decreased 5-HT and increased histamine metabolism, and impulsivity to decreased 5-HT metabolism, decreased degradation of catecholamines, and to pyrroluria; in both cases, stress (which can be related to DST and cortisol concentration in blood and CSF findings) was thought to be a significant factor.…”

Section: Suicide Aggressivity and Impulsivitymentioning

confidence: 99%

The Involvement of Serotonin in Psychiatric Disorders and Behaviour

López-Ibor

1988

Br J Psychiatry

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There is evidence that serotonin (5-HT) is involved both in a wide range of psychiatric conditions and in specific behaviours which, in themselves, cannot be considered pathological. Besides the affective disorders (both depressive and manic, and both in full-blown episodes and during the intervals between these, which are seen as vulnerability to relapse) several other conditions need to be considered (Table I). There are also claims that serotonin metabolites or structurally related substances are involved, in their role as false neurotransmitters, in delusions and psychedelic phenomena, as in the case of LSD (Mantegazzini, 1960) or 5-hydroxytryptolines in delusions related to alcoholism (Daviset al, 1967).This wide range of conditions raises the questions of how specific is the involvement of serotonin, and of what artifacts are present in attempts to investigate its actions. Page, who isolated 5-HT in 1948, stated (1968) that “serotonin has many functions but few have been sharply defined. The great variety of suggested roles can be said to be a tribute to man's ingenuity and his unquestionable willingness to write papers”. Since then, many more roles have been proposed for the involvement of 5-HT in functions of the central nervous system. Nevertheless, good evidence does exist that serotonin has some specific relationships to psychiatric disorders which are worth pursuing, in spite of great methodological difficulties.

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“…Many mental health problems: Panic attacks-treat food allergies; deal with magnesium deficiency; give breathing exercise to counteract faulty chronic hyperventilation: 59 anxiety and depression-treat nutritional deficiencies, 60 food intolerances 61 or candida: 42 schizophrenia-treat food intolerances; 62 redress nutritional deficiencies; 63 give folic acid. 64 Preconceptional and pregnancy care and infertility: Diagnose and treat B vitamin, mineral and fatty acid deficiencies; 65 · 66 • 67 give folic acid to cut down the risk of neural tube defects.…”

Section: What Sort Of Diseases and Conditions Can We Treat?mentioning

confidence: 99%

What is Nutritional Medicine?

Meldrum

1993

Nutr Health

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Nutritional Medicine is based on the principle that nutrients, including essential micronutrients, are required for the proper functioning of all the biochemical processes on which our bodies depend. Therefore, when treating symptoms or diseases, we look for the underlying causes which, although often partly genetic, are usually very much tied up with nutritional and environmental factors. This is in contrast to the tendency in the conventional medical approach to treat symptoms by means of drugs or surgery.

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Copper, Zinc, Manganese, Niacin and Pyridoxine in the Schizophrenias

Cited by 7 publications

References 38 publications

Atherogenicity, Oxidative Stress, Heavy Metals and Bioelements Status in Hypertensive Nigerians in an Urban Population

Atherogenicity, Oxidative Stress, Heavy Metals and Bioelements Status in Hypertensive Nigerians in an Urban Population

The Involvement of Serotonin in Psychiatric Disorders and Behaviour

What is Nutritional Medicine?

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