Copper: Synthesis Techniques in Nanoscale and Powerful Application as an Antimicrobial Agent

Abstract

Nanosized metal particles show specific physical and chemical properties that allow the creation of new composites materials, which are important for multiple applications in biology and medicine such as infections control. Metal nanoparticles, mainly copper, exhibit excellent inhibitory effect on Gram-positive and Gram-negative bacteria; therefore the exploration about the efficient, economical, and friendly environmental technics to synthesize inorganic nanoparticles is imperative. In this work a brief overview of the several methods is made including the comparison of the methods, mainly between sonochemical, microwave, and chemical routes. It allows determining the optimal parameters and technical conditions to synthesize copper nanoparticles with physical and chemical properties suitable for the oral bacterial inhibition.

Antimicrobial Nanostructured Coatings: A Gas Phase Deposition and Magnetron Sputtering Perspective

“…The strategies developed to control the incidence of infections should depend on the applications which they are devised for, i.e., on the type of surface where the antimicrobial agent has to be located, since the topological and chemical characteristics of a surface determine the rate of microorganism adhesion [19,21,46,48]. In the framework of synthesis of nanostructured coatings with antimicrobial properties, the main explored strategies range from modification of surfaces through deposition of polymeric films [19,21,45,[49][50][51] with incorporated bactericidal agents [21,[52][53][54][55], or deposition of metallic or oxide films [2,21,56]. For instance, Ag can broaden the bactericidal activity of TiO 2 -based photocatalyst composite materials and can also act against silver-resistant microorganisms due to their photooxidative mechanism [57].…”

“…Many different routes have been explored to synthesize NMs and NPs, from deposition of polymeric films [19,21,45,[49][50][51] with incorporated bactericidal agents [21,[52][53][54][55], or metallic or oxide films [2,21,56,57], to metal decoration of nanostructures [58][59][60]. The strategies are based on wet synthesis (spin-coating [61], sol-gel [57,61,62]), photochemical [52], biological [63][64][65], biotechnological [24] and physical methods (laser ablation [66], magnetron sputtering (MS) [2,44,[67][68][69], gas phase beams [70,71]).…”

Biogenic synthesis of copper oxide nanoparticles using olea europaea leaf extract and evaluation of their toxicity activities: An in vivo and in vitro study

“…Copper is highly toxic to microorganisms, such as Escherichia coli, Pseudomonas aeruginosa , and Staphylococcus aureus . Given these phenomena, they are considered effective bactericidal metals . Recently, several studies have been established to prove their potentials in biomedical field using in vitro and in vivo models .…”

Acrílico termopolimerizable enriquecido con nanopartículas de cobre: evaluación antibacteriana y citotóxica

“…Caracterización El cobre, conocido desde hace mucho tiempo por su actividad antibacteriana y por su costo relativamente bajo, es un atractivo agente biocida (Camacho-Flores et al, 2015). El coste económico de las nps de cobre es bajo en comparación con otros nanomateriales metálicos como el oro y la plata.…”

“…Las nanopartículas metálicas más utilizadas y estudiadas en cuanto a su efecto antibacterial son las de dióxido de titanio, plata y óxido de zinc. Sin embargo en fechas recientes las nanopartículas de cobre (Cu nps) han resultado un área de interés debido a sus propiedades antimicrobianas y antifúngicas, lo que lo hace un elemento promisorio y potencialmente viable para distintas aplicaciones (Camacho-Flores et al, 2015). En un estudio in vitro evaluó la actividad antimicrobiana de las Cu nps y se encontró que la concentración mínima inhibitoria (mic) fue de 10 μg/ml para E. coli, mientras que para S. aureus y S. mutans fue de 100 μg/ml.…”