Copper-Silver Nanohybrids: SARS-CoV-2 Inhibitory Surfaces

Mosselhy, Dina A.; Kareinen, Lauri; Kivistö, Ilkka; Aaltonen, Kirsi; Virtanen, Jenni; Ge, Yanling; Sironen, Tarja

doi:10.3390/nano11071820

Cited by 21 publications

(30 citation statements)

References 32 publications

(35 reference statements)

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“…All particles were measured from a sum of 10 particles. Comparing these results with those obtained in our previous study for surfaces provided by the same manufacturer and inhibited SARS-CoV-2 Wuhan reference strain [ 20 ], the present samples (A, B, and C) possessed smaller copper particles and much larger Ag particles. Besides, the star-shaped and flower-shaped morphologies of Ag NPs in samples A and B were not reported in our same previous work [ 20 ].…”

Section: Resultssupporting

confidence: 83%

Inhibition of SARS-CoV-2 Alpha Variant and Murine Noroviruses on Copper-Silver Nanocomposite Surfaces

et al. 2022

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With the continued scenario of the COVID-19 pandemic, the world is still seeking out-of-the-box solutions to break its transmission cycle and contain the pandemic. There are different transmission routes for viruses, including indirect transmission via surfaces. To this end, we used two relevant viruses in our study. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the pandemic and human norovirus (HuNV), both known to be transmitted via surfaces. Several nanoformulations have shown attempts to inhibit SARS-CoV-2 and other viruses. However, a rigorous, similar inactivation scheme to inactivate the cords of two tedious viruses (SARS-CoV-2 Alpha variant and HuNV) is lacking. The present study demonstrates the inactivation of the SARS-CoV-2 Alpha variant and the decrease in the murine norovirus (MNV, a surrogate to HuNV) load after only one minute of contact to surfaces including copper–silver (Cu–Ag) nanocomposites. We thoroughly examined the physicochemical characteristics of such plated surfaces using diverse microscopy tools and found that Cu was the dominanting element in the tested three different surfaces (~56, ~59, and ~48 wt%, respectively), hence likely playing the major role of Alpha and MNV inactivation followed by the Ag content (~28, ~13, and ~11 wt%, respectively). These findings suggest that the administration of such surfaces within highly congested places (e.g., schools, public transportations, public toilets, and hospital and live-stock reservoirs) could break the SARS-CoV-2 and HuNV transmission. We suggest such an administration after an in-depth examination of the in vitro (especially on skin cells) and in vivo toxicity of the nanocomposite formulations and surfaces while also standardizing the physicochemical parameters, testing protocols, and animal models.

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Section: Resultssupporting

confidence: 83%

Inhibition of SARS-CoV-2 Alpha Variant and Murine Noroviruses on Copper-Silver Nanocomposite Surfaces

et al. 2022

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“…In terms of the post-COVID-19 closed space design, authors consider the increase in the surface and the volume of rooms [3], as well as the development and application of virus-resistant materials and coatings [108][109][110][111][112].…”

Section: Reflections On Post-covid-19 Urban Spacementioning

confidence: 99%

COVID-19 and City Space: Impact and Perspectives

Glavan¹,

Nikolić²,

Folić³

et al. 2022

Sustainability

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The pandemic of the COVID-19 disease has radically changed human lifestyle and the usage of living space, especially in cities. With the prolongation of the crisis, the effects of COVID-19 on urban spaces are becoming more noticeable, but the definite changes that can inform approaches to future development, planning, and use of urban space have not yet been determined, as evidenced by the research carried out in this study. The research revealed that there exists the consensus in terms of several new guidelines whose application in design can simultaneously increase the resilience of urban environment to future pandemics and improve the overall quality of city life. These presented guidelines show that we may expect in the future a greater integration of nature-based solutions at various scales of the city, i.e., better ventilated, and naturally lit, more spacious, mixed-use, and flexible buildings surrounded by enlarged, multiplied, and multifunctional open spaces that safely receive the users who are carrying out those activities that were moved from the inner to the outer space.

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“… 38 , 39 Much recent progress has been achieved on the surface of stainless steel using Ag coatings and on facial masks using Cu compounds and copper–silver (Cu–Ag) nanohybrids against SARS-CoV-2. 40 − 42 However, demonstration and use of NPs as antiviral coatings on plastic surfaces remains rare. There are three major strategies to achieve antimicrobial polymers, namely, (a) incorporate antimicrobial agents directly into polymers during plastic processing, (b) coat or immobilize antimicrobials onto polymer surfaces, and (c) use polymers that are inherently antimicrobial.…”

mentioning

confidence: 99%

Enhancement of Antiviral Effect of Plastic Film against SARS-CoV-2: Combining Nanomaterials and Nanopatterns with Scalability for Mass Manufacturing

et al. 2021

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Direct contact with contaminated surfaces in frequently accessed areas is a confirmed transmission mode of SARS-CoV-2. To address this challenge, we have developed novel plastic films with enhanced effectiveness for deactivating the SARS-CoV-2 by means of nanomaterials combined with nanopatterns. Results prove that these functionalized films are able to deactivate SARS-CoV-2 by up to 2 orders of magnitude within the first hour compared to untreated films, thus reducing the likelihood of transmission. Nanopatterns can enhance the antiviral effectiveness by increasing the contact area between nanoparticles and virus. Significantly, the established process also considers the issue of scalability for mass manufacturing. A low-cost process for nanostructured antiviral films integrating ultrasonic atomization spray coating and thermal nanoimprinting lithography is proposed. A further in-depth investigation should consider the size, spacing, and shape of nanopillars, the type and concentration of nanoparticles, and the scale-up and integration of these processes with manufacturing for optimal antiviral effectiveness.

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Copper-Silver Nanohybrids: SARS-CoV-2 Inhibitory Surfaces

Cited by 21 publications

References 32 publications

Inhibition of SARS-CoV-2 Alpha Variant and Murine Noroviruses on Copper-Silver Nanocomposite Surfaces

Inhibition of SARS-CoV-2 Alpha Variant and Murine Noroviruses on Copper-Silver Nanocomposite Surfaces

COVID-19 and City Space: Impact and Perspectives

Enhancement of Antiviral Effect of Plastic Film against SARS-CoV-2: Combining Nanomaterials and Nanopatterns with Scalability for Mass Manufacturing

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