Copper, Selenium, and Zinc Status and Balances after Major Trauma

Berger, Mette M.; Cavadini, C.; Chioléro, René; Dirren, Henri

doi:10.1097/00005373-199601000-00019

Cited by 85 publications

(28 citation statements)

References 25 publications

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“…The dotted lines indicate upper and lower limits of the respective reference ranges The present study is an extension of previous investigations in severely injured patients in whom we documented a classical nonthyroidal illness syndrome associated with an altered Se status [17]. Similar patients with comparable types of injury were included in the present study [1]. In these patients, low plasma Se concentrations were also observed already on admission, due to acute losses, acute phase response, and dilution: they normalised slowly in the placebo group.…”

Section: Discussionmentioning

confidence: 70%

“…But a daily dose of 500 mg, i.e., ten times the recommended dose, for 5 days may not be sufficient to influence the Se-dependent biochemical responses in critically ill patients. This quantity was selected considering: (1) the results of our previous balance study [1]; (2) the nutritional requirements of 30±60 mg/day; and (3) the results of a Venezuelan study indicating that Se intakes above 500 mg/ day are associated with an inhibition of the hepatic deiodinase [29]. One may also argue that the absence of major difference between supplemented and placebo groups may be due to both groups having received some Se, since the placebo group indeed received about 105 mg/day compared with 555 mg/day in the Se group.…”

Section: Discussionmentioning

confidence: 99%

“…From D0 to D5, the detailed intakes (crystalloids, colloids, blood products, nutrients) were recorded on a 24-h basis, and the Se content was calculated [1].…”

Section: Timingmentioning

confidence: 99%

“…Trauma patients exhibit an acute and severe form of this disorder [13,14], which has been shown to be a prognostic factor in critically ill and brain injured patients [13,15,16]. We previously observed strongly depressed trace element levels in trauma patients upon admission to the intensive care unit (ICU) [1]. Selenium and zinc changes were extensive and long-lasting, with negative balances during the first week after injury.…”

mentioning

confidence: 99%

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IntroductionTrace element metabolism is altered after major trauma [1]. The largest changes concern selenium (Se), which is essential for the activity of two important families of selenoproteins.

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mentioning

confidence: 99%

See 4 more Smart Citations

Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trial

Berger¹,

Reymond

Shenkin

et al. 2000

Intensive Care Med

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

“…From D0 to D5, the detailed intakes (crystalloids, colloids, blood products, nutrients) were recorded on a 24-h basis, and the Se content was calculated [1].…”

Section: Timingmentioning

confidence: 99%

mentioning

confidence: 99%

“…

IntroductionTrace element metabolism is altered after major trauma [1]. The largest changes concern selenium (Se), which is essential for the activity of two important families of selenoproteins.

…”

mentioning

confidence: 99%

See 3 more Smart Citations

Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trial

Berger¹,

Reymond

Shenkin

et al. 2000

Intensive Care Med

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Effect of zinc supplement on patients with trauma: A systematic review and meta‐analysis

Huang

Chan

et al. 2023

J Parenter Enteral Nutr

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Aims: This study aimed to assess the effect of zinc supplementation, with or without other antioxidants and trace elements, on clinical outcomes in patients with trauma.Methods: A systematic review was conducted for adult patients with acute trauma who had been admitted to the hospital. Those who sustained burn injuries were excluded. Studies in PubMed, Web of Science, and Embase from 1990 to 2022 regarding the additional nutrition supplementation of zinc to patients, either in a single-agent or combined regimen, were included. Comparisons were made between the zinc supplement group and those who received a placebo or regular treatment. Results:The primary outcomes of the study were mortality rate, length of hospital stay, and incidence of pneumonia. Seven studies qualified for the meta-analysis. Of the 594 patients eligible for analysis, 290 and 304 were in the zinc supplementation and control groups, respectively. The meta-analysis revealed that zinc supplementation was associated with a lower risk of pneumonia in patients with acute trauma than in the control group (odds ratio [OR], 0.506; 95% CI = 0.292-0.877; P = 0.015; heterogeneity, I 2 = 12.7%). Zinc supplementation did not influence the mortality rate (OR, 0.755; 95% CI = 0.492-1.16; P = 0.612; heterogeneity, I 2 = 0%) or the length of hospital stay (standard difference in means, −0.24; 95% CI = −0.544 to 0.063; P = 0.121; heterogeneity, I 2 = 45.0%). Conclusion:Zinc supplementation, with or without other antioxidants and trace elements, in patients with trauma was associated with a lower incidence of pneumonia.

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Copper Deficiency: Causes, Manifestations, and Treatment

et al. 2019

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Background: The metabolism of the essential trace element copper remains incompletely understood and, until recently, nearly ignored in acute medicine. Menkes disease was for long the only known copper deficiency condition, but several case reports and investigations conducted over the last 2 decades have shown that deficiency is more frequent than previously suspected, with devastating individual consequences and potential public health consequences. The copper needs in healthy individuals are 0.9 mg/d, which translates to 0.3 mg/d intravenously in parenteral nutrition; the present review aims at gathering actual knowledge. Method and results: A review of literature was conducted in PubMed and Cochrane systematic reviews to identify the most recent information about copper deficiency and generate a narrative review. Copper deficiency has hereditary and acquired origins, the latter being the most frequent. Clinical manifestations are nonspecific but affect all organs and systems, particularly the hematologic (anemia) and the neurologic (myeloneuropathy) systems. Deficiency also affects the cardiovascular, cutaneous, and immune systems. Severe copper deficiency due to reduced absorption after bariatric bypass surgery has become frequent. Conclusion: Deficiency is more frequent than previously recognized, probably because of changing nutrition patterns but also because of some treatments that have become very common such as bypass bariatric surgery and, in acute medicine, prolonged continuous renal replacement therapy. The patients may present with severe hematologic and neurologic complications that go untreated because copper deficiency was not considered in the differential diagnosis: These complications often need active intravenous repletion with doses 4-8 times the usual nutrition recommendations. (Nutr Clin Pract. 2019;34:504-513)

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Copper, Selenium, and Zinc Status and Balances after Major Trauma

Cited by 85 publications

References 25 publications

Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trial

Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trial

Effect of zinc supplement on patients with trauma: A systematic review and meta‐analysis

Copper Deficiency: Causes, Manifestations, and Treatment

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