Copper-Salicylate in Rheumatoid Arthritis and Similar Degenerative Diseases

Hangarter, W.

doi:10.1007/978-1-4612-5829-2_40

Cited by 9 publications

(2 citation statements)

References 7 publications

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“…For example, a copper-salicylate mixture, marked until 1971 with the commercial name of Permalon, was used in uncontrolled trials in 600 arthritic patients obtaining, in the opinion of rheumatologists, 'very successful results' [62]. The administration of copper preparations, however, is not the only way to tackle the problem.…”

Section: Possible Relevance To Therapy Of the Copper Approachmentioning

confidence: 98%

Review: Copper and inflammation — a possible rationale for the pharmalogical manipulation of inflammatory discorders

et al. 1985

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Acute and chronic inflammations are characterized, among other features, by changes in the metabolism of copper and by a widespread responsiveness to the therapy with copper-containing molecules. The exact map of inflammation-induced copper movements as well as the role played by the metal in the pathogenesis of inflammatory disorders are, however, far from being clear, and this is especially true in the case of chronic processes. Nevertheless the present knowledge suggests that the "copper approach' may provide a new way for coping with the problem of anti-inflammatory/anti-arthritic therapies. The administration of exogenous copper, and the in vivo manipulation of the endogenous metal levels are proposed as two possible therapeutic strategies, not necessarily mutually exclusive. For a better understanding of the value of such an approach, further research work is needed, especially to attain a more detailed know-how on the involved chemical forms, distribution and functions of copper in both normal as well as inflamed organisms.

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Section: Possible Relevance To Therapy Of the Copper Approachmentioning

confidence: 98%

Review: Copper and inflammation — a possible rationale for the pharmalogical manipulation of inflammatory discorders

et al. 1985

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“…The induction of either acute or chronic inflammatory processes promotes a net accumulation of copper in many body compartments, the inflamed area included [5 and references therein]. Finally, over 100 copper-containing molecules have been shown to be active as anti-inflammatory agents in the laboratory animals [6], and the Cu-Zn superoxide dismutase [7] as well as the Cu(II)-salicylate complex [8] have also been successfully used to treat human rheumatoid arthritis.…”

Section: Introductionmentioning

confidence: 99%