Copper and Inflammation

Deuschle, Ulrich; Weser, Ulrich

doi:10.1007/978-3-642-70570-0_3

Cited by 26 publications

(7 citation statements)

References 136 publications

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“…These activities are consistent with superoxide dismutase (SOD)dike activity and the role of copper complexes in the physiological response to these types of diseases (Sorenson 1982, Deuschle & Weser 1985. For the copper mediated catalytic dismutation of superoxide there is no difference whether or not the metal is bound to low molecular weight ligands or coordinated to amino acid residues within large protein molecules.…”

Section: Introductionsupporting

confidence: 56%

Pulse radiolytically determined superoxide dismutase mimicking activity of copper-putrescine-pyridine, a diSchiff base coordinated copper complex

et al. 1993

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In order to exclude possible interferences in the many indirect superoxide dismutase (SOD) activity measurements using the copper-putrescine-pyridine complex (Cu-PuPy) a pulse radiolytic study on this diSchiff base copper complex has been devised and sucessfully performed. The reaction kinetics and rate constants of pulse radiolytically generated superoxide in the presence of Cu-PuPy reveal pseudo first-order characteristics. The rate constant (k 2 = 6 + 1 • l0 s ~1 -! s -t) is comparable to that of an Fe-SOD and is approximately a factor of 3 lower than that of bovine Cu2Zn2-SOD. The superoxide dismutating activity of Cu-PuPy shows a more pronounced temperature dependence compared with that of Cu2Zn2-SOD. Arrhenius analyses yielded activation energies of 7.8 +_0.3 and 4.6 +_ 0.2 kcalmo1-1 for Cu-PuPy and Cu2Zn2-SOD, respectively. The rate constant of the reaction of superoxide and Cu-PuPy is highest at pH 5.0. The possible application of Cu-PuPy for new therapeutic strategies on all types of inflammatory diseases appears to be promising.

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Section: Introductionsupporting

confidence: 56%

Pulse radiolytically determined superoxide dismutase mimicking activity of copper-putrescine-pyridine, a diSchiff base coordinated copper complex

et al. 1993

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“…acetylsalicylic acid among them) have antiinflammatory, antiulcer, antidiabetic, antimutagenic and radioprotective activity [7,8]. Though the way of action of copper-based non-steroidal anti-inflammatory drugs is not known in every detail, there is much evidence that it is based on the inhibition of prostaglandin synthesis via the cyclooxygenase isoenzyme system, and it may be related to the modulation of superoxide dismutation, nitric oxide synthetase, and some immunobiological functions [4][5][6]9,10]. It has been suggested that the active form of ASPIRIN is, in fact, a copper complex formed in vivo [11].…”

Section: Introductionmentioning

confidence: 98%

“…The antirheumatic activity of copper(II) ions, recognized at first by vineyardists hundreds of years ago [1], stimulated coordination chemists to investigate the composition, structure, reactivity and biological activity of copper(II) complexes with antirheumatically active organic compounds [2]. It has been established that the metal complexes are generally more active than the drugs themselves [3][4][5][6]. The copper(II) complexes of salicylic acid and its derivatives (with ASPIRIN, i.e.…”

Section: Introductionmentioning

confidence: 99%

Complexation of 5-fluorosalicylic acid with copper(II): A pH-potentiometric, UV–vis spectroscopic, and electron spin resonance study by the two-dimensional simulation of spectra

Szabó-Plánka¹,

Gyurcsik²,

Nagy³

et al. 2008

Journal of Inorganic Biochemistry

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“…This could also be an explanation for the significant sex differences in segmented granulocytes, and gamma-globulin, iron and copper concentration in serum. It is well recognised that inflammatory processes decrease the iron concentration and increase the concentration of copper, segmented granulocytes and B-and gamma-globulins in serum (5,31,41). The significant difference between eosinophil counts in the blood of gilts and castrated males is in agreement with a study of Rossi (30).…”

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confidence: 99%

Haematological and clinicochemical blood profiles in slaughter pigs

Elbers

Counotte²,

Tielen

1992

Veterinary Quarterly

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SUMMARYIn a cohort study, 40 pig finishing herds were selected twenty pig herds with a low and twenty pig herds with a high prevalence of several pathological lesions recorded at slaughter in a six-month period before the start of the study. Blood samples were taken from 20 pigs per herd at the end of the finishing period to investigate haematological and clinicochemical profiles. There was only a significant difference in serum albumin concentration between the low and high lesion prevalence groups. There were distinct differences in blood profiles between pig herds, but also between batches of pigs within a herd housed in different compartments. Differences between castrated males and gilts were also demonstrated with respect to mean values of the blood variables haemoglobin, iron, copper,fl-globulin, eosinophils and segmented neutrophils. However, the differences were not of a biologically important magnitude. The mean values of the blood variables pepsinogen and lymphocytes differed significantly between pig herds from the two participating integration groups.

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Copper and Inflammation

Cited by 26 publications

References 136 publications

Pulse radiolytically determined superoxide dismutase mimicking activity of copper-putrescine-pyridine, a diSchiff base coordinated copper complex

Pulse radiolytically determined superoxide dismutase mimicking activity of copper-putrescine-pyridine, a diSchiff base coordinated copper complex

Complexation of 5-fluorosalicylic acid with copper(II): A pH-potentiometric, UV–vis spectroscopic, and electron spin resonance study by the two-dimensional simulation of spectra

Haematological and clinicochemical blood profiles in slaughter pigs

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