Copper-releasing, boron-containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering

Erol, M.; Mouriño, Viviana; Newby, P.; Chatzistavrou, Xanthippi; Roether, Judith A.; Hupa, Leena; Boccaccını, Aldo R.

doi:10.1016/j.actbio.2011.10.013

Cited by 121 publications

(80 citation statements)

References 61 publications

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“…consistent with results reported in the literature[67,68], can be attributed to the formation of hydroxyapatite phase. Additionally, characteristic peaks appeared at 875 cm −1 and 959 cm −1 which indicate the presence…”

supporting

confidence: 93%

Alginate/Bioglass® composite coatings on stainless steel deposited by direct current and alternating current electrophoretic deposition

Chen

Cordero-Arias

Roether

et al. 2013

Surface and Coatings Technology

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supporting

confidence: 93%

Alginate/Bioglass® composite coatings on stainless steel deposited by direct current and alternating current electrophoretic deposition

Chen

Cordero-Arias

Roether

et al. 2013

Surface and Coatings Technology

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“…In addition, Cu 2þ ions also enhance the differentiation of stem cells towards the osteogenic linage [54,59]. Furthermore, Cu 2þ is a natural antimicrobial material [45,47] and also reported was a synergistic antimicrobial effect with Ca 2þ [60].…”

Section: Introductionmentioning

confidence: 95%

Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

Cattalini

Hoppe

Pishbin

et al. 2015

J. R. Soc. Interface.

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This work aimed to develop novel composite biomaterials for bone tissue engineering (BTE) made of bioactive glass nanoparticles (Nbg) and alginate cross-linked with Cu 2þ or Ca 2þ (AlgNbgCu, AlgNbgCa, respectively). Twodimensional scaffolds were prepared and the nanocomposite biomaterials were characterized in terms of morphology, mechanical strength, bioactivity, biodegradability, swelling capacity, release profile of the cross-linking cations and angiogenic properties. It was found that both Cu 2þ and Ca 2þ are released in a controlled and sustained manner with no burst release observed. Finally, in vitro results indicated that the bioactive ions released from both nanocomposite biomaterials were able to stimulate the differentiation of rat bone marrow-derived mesenchymal stem cells towards the osteogenic lineage. In addition, the typical endothelial cell property of forming tubes in Matrigel was observed for human umbilical vein endothelial cells when in contact with the novel biomaterials, particularly AlgNbgCu, which indicates their angiogenic properties. Hence, novel nanocomposite biomaterials made of Nbg and alginate cross-linked with Cu 2þ or Ca 2þ were developed with potential applications for preparation of multifunctional scaffolds for BTE.

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“…is more appropriate because they show antimicrobial activity at the site of implant materials and they are not cytotoxic at low concentrations [9][10][11][12]. Besides its antimicrobial activity, Cu is an essential trace element for mammalian life [10,13], and it stimulates the activity of several enzymes and plays a role in the crosslinking of collagen and elastin of bones [10,14].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial efficacy, corrosion resistance, and cytotoxicity studies of copper-substituted carbonated hydroxyapatite coating on titanium substrate

et al. 2014

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This work elucidated the antibacterial efficacy, corrosion resistance, and cytotoxicity of electroplated copper-substituted hydroxyapatite (CuHAP) coating on titanium (Ti). The fabricated CuHAP coatings were characterized by scanning electron microscopy, energydispersive X-ray analysis spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction studies. The CuHAP coating had needle-like apatite crystals, the doping of Cu 2? into HAP reduced porosity, and the coating became denser. The CuHAP crystals were carbonated with a few of Cu 2? incorporation (about 0.80 wt%). The Cu 2? ions were homogenously deposited into HAP films. Potentiodynamic polarisation test revealed that the CuHAP coating provided good barrier characteristics and achieved superior corrosion protection for Ti substrates. The in vitro antibacterial activity of asprepared CuHAP coating was evaluated against Escherichia coli and was found to be effectively high against bacterial colonization. Bioactivity test conducted by soaking the coatings in simulated body fluid demonstrated that CuHAP coating can quickly induce bone-like apatite nucleation and growth. In vitro biocompatibility tests, MTT, were employed to assess the cytotoxicity of Cu-HAP coating with osteoblast-like MC3T3-E1 cells. The obtained HAP coating doped with a low content of Cu 2? exhibited good cytocompatibility and had no toxicity toward MC3T3-E1.

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Copper-releasing, boron-containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering

Cited by 121 publications

References 61 publications

Alginate/Bioglass® composite coatings on stainless steel deposited by direct current and alternating current electrophoretic deposition

Alginate/Bioglass® composite coatings on stainless steel deposited by direct current and alternating current electrophoretic deposition

Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

Antibacterial efficacy, corrosion resistance, and cytotoxicity studies of copper-substituted carbonated hydroxyapatite coating on titanium substrate

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