Copper-oxide impregnated respiratory masks may significantly reduce the risk of SARS-CoV-2 cross-contamination

Borkow, Gadi; Lustiger, Danny; Melamed, Eyal; Herrera, Vicki L.; Ackerman, Daniel N.; Reid, St Patrick; Santarpia, Joshua L.

doi:10.21203/rs.3.rs-60610/v1

Cited by 9 publications

(10 citation statements)

References 22 publications

(23 reference statements)

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“…These masks presented excellent antiviral activity by inactivating the SARS-CoV-2 virus up to 99.9% with confirmation by serial PCR test and TCID 50 analysis. 100 A similar type of study was reported by Sunghoon and coworkers, in which a Cu-coated polypropylene layer was deposited on the surface of commercial KF94 masks using oxygen ion beam treatment and DC magnetron sputtering, as shown in Fig. 3(a).…”

Section: Cu-based Nanomaterialsmentioning

confidence: 63%

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Antiviral effects of coinage metal-based nanomaterials to combat COVID-19 and its variants

2022

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Section: Cu-based Nanomaterialsmentioning

confidence: 63%

“…These masks presented excellent antiviral activity by inactivating the SARS-CoV-2 virus up to 99.9% with confirmation by serial PCR test and TCID 50 analysis. 100…”

Section: Coinage Metals and Their Antiviral Abilitymentioning

confidence: 99%

Antiviral effects of coinage metal-based nanomaterials to combat COVID-19 and its variants

2022

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“…They observed a 75% reduction in viral load after 1 h incubation with SARS-CoV-2 [44]. Borkow reported a similar result for Cu coated masks with 99.9% inactivation of the pathogen within 1 min using TCID 50 and PCR assays [45]. Balagna et al developed a silver cluster/silica composite sputter coating onto a mask and observed a 2-to 4-log reduction in SARS-CoV-2 after 1.5 h incubation [46].…”

Section: Discussionmentioning

confidence: 83%

A Novel Antipathogenic Agent for Nonwoven Fabric

Simpson

McMinn

Mondfrans

et al. 2022

Biomedical Materials & Devices

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Medical-grade masks and N95 respirators containing non-woven fibers are designed to prevent the spread of airborne diseases. While they effectively trap respiratory droplets and aerosols, they cannot lyse entrapped pathogens. Embedded antimicrobial agents such as silver, copper, zinc, iodine, peptides, quaternary ammonium salts, or nanoparticles have been used to overcome this limitation. However, their effectiveness remains debatable because these materials can be toxins, allergens, irritants, and environmental hazards. Recently, silicon nitride (Si3N4) was found to be a potent antipathogenic compound, and it may be an ideal agent for masks. In powder or solid form, it is highly effective in inactivating bacteria, fungi, and viruses while leaving mammalian tissue unaffected. The purpose of this study was to serially assess the antiviral efficacy of Si3N4 against SARS-CoV-2 using powders, solids, and embedded nonwoven fabrics. Si3N4 powders and solids were prepared using conventional ceramic processing. The “pad-dry-cure” method was used to embed Si3N4 particles into polypropylene fibers. Fabric testing was subsequently conducted using industrial standards—ISO 18184 for antiviral effectiveness, ASTM F2299 and EN 13274-7 for filtration efficiency, EN 14683 for differential pressure drop, and ISO 18562-2 for particle shedding. A modification of ISO 18562-3 was also employed to detect ammonia release from the fabric. Antiviral effectiveness for Si3N4 powders, solids, and embedded fabrics were 99.99% at ≤ 5 min, ~ 93% in 24 h, and 87% to 92% in 120 min, respectively. Results of the standard mask tests were generally within prescribed safety limits. Further process optimization may lead to commercial Si3N4-based masks that not only “catch” but also “kill” pathogenic microbes.

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“…Different mechanisms of action of nanomaterials in consideration of Au and Ag nanoparticles with antimicrobial properties of nanoparticles, Cu antiviral effects, daylight or under UV light self-cleaning properties of TiO 2 and ZnO nanoparticles have been used. 137 , 149 − 152 Among these new types of nanomaterials are examples made with polymeric materials. Self-cleaning surfaces have been obtained thanks to the super-hydrophobic property added to the modification and design of nanomaterials.…”

Section: Nanomaterial-based Coatings For the Fight Against Covid-19mentioning

confidence: 99%

Nanostructures for the Prevention, Diagnosis, and Treatment of SARS-CoV-2: A Review

Kiremitler

Kemerli

Kayacı

et al. 2022

ACS Appl. Nano Mater.

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Scientists, doctors, engineers, and even entire societies have become aware of the seriousness of the COVID-19 infection and are taking action quickly, using all the tools from protection to treatment against coronavirus SARS-CoV-2. Especially in this sense, scientific approaches and materials using nanotechnology are frequently preferred. In this review, we focus on how nanoscience and nanotechnology approaches can be used for protective equipment, diagnostic and treatment methods, medicine, and vaccine applications to stop the coronavirus SARS-CoV-2 and prevent its spread. SARS-CoV-2, which itself can be considered as a core–shell nanoparticle, can interact with various materials around it and remain bound for variable periods of time while maintaining its bioactivity. These applications are especially critical for the controlled use of disinfection systems. One of the most important processes in the fight against coronavirus is the rapid diagnosis of the virus in humans and the initiation of isolation and treatment processes. The development of nanotechnology-based test and diagnostic kits is another important research thrust. Nanotechnological therapeutics based on antiviral drug design and nanoarchitecture vaccines have been vital. Nanotechnology plays critical roles in the production of protective film surfaces for self-cleaning and antiviral masks, gloves, and laboratory clothes. An overview of literature studies highlighting nanotechnology and nanomaterial-based approaches to combat SARS-CoV-2 is presented.

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Copper-oxide impregnated respiratory masks may significantly reduce the risk of SARS-CoV-2 cross-contamination

Cited by 9 publications

References 22 publications

Antiviral effects of coinage metal-based nanomaterials to combat COVID-19 and its variants

Antiviral effects of coinage metal-based nanomaterials to combat COVID-19 and its variants

A Novel Antipathogenic Agent for Nonwoven Fabric

Nanostructures for the Prevention, Diagnosis, and Treatment of SARS-CoV-2: A Review

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