Copper-nickel oxide nanofilm modified electrode for non-enzymatic determination of glucose

Abstract

<p class="PaperAbstract">Cu<sub>x</sub>O-NiO nanocomposite film for the non-enzymatic determination of glucose was prepared by the novel modifying method. At first, anodized Cu electrode was kept in a mixture solution of CuSO<sub>4</sub>, NiSO<sub>4</sub> and H<sub>2</sub>SO<sub>4</sub> for 15 minutes. Then, a cathodization process with a step potential of -6 V in a mixture solution of CuSO<sub>4</sub> and NiSO<sub>4</sub> was initiated, generating formation of porous Cu-Ni film on the bare Cu electrode by electrodeposition assisted by the release of hydrogen bubbles acting as soft templates. Optimized conditions were determined by the experimental design software for electrodeposition process.<strong> </strong>Afterward, Cu-Ni modified electrode was scanned by cyclic voltammetry (CV) method in NaOH solution to convert Cu and Ni nanoparticles to the nano-scaled Cu<sub>x</sub>O-NiO film. The electrocatalytic behavior of the novel Cu<sub>x</sub>O-NiO film toward glucose oxidation was studied by CV and chronoamperometry (CHA) techniques. The calibration curve of glucose was found linear in a wide range of 0.04–5.76 mM, with a low limit of detection (LOD) of 7.3 µM (S/N = 3) and high sensitivity (1.38 mA mM<sup>-1</sup> cm<sup>-2</sup>). The sensor showed high selectivity against some usual interfering species and high stability (loss of only 6.3 % of its performance over one month). The prepared Cu<sub>x</sub>O-NiO nanofilm based sensor was successfully applied for monitoring glucose in human blood serum and urine samples.</p>

Recent advances in nanomaterials-based electrochemical sensors for tramadol analysis

“…Nanotechnology refers to the branch of science and engineering devoted to designing, producing, and using structures, devices, and systems by manipulating atoms and molecules at the nanoscale, i.e., having one or more dimensions of the order of 100 nanometres or less. Nanotechnology is used to revolutionize many technology and industry sectors: electronics, energy, material science, medicine, transportation, transportation, and environmental science, to name a few [39][40][41][42][43][44]. The reasons for their growing applications relate to their unique physical and chemical properties, which are entirely different from their bulk counterparts [45].…”

Focus Review on Nanomaterial-Based Electrochemical Sensing of Glucose for Health Applications

“…Another sensor was reported which was based on a CuxO-NiO nanocomposite fabricated by a novel procedure involving first the electrodeposition of porous Cu-Ni nanofilm on an anodized copper electrode, working at a cathodic potential at which hydrogen bubbles evolution occurs, and then the potentiodynamic oxidation of the metal nanofilm in a NaOH solution [ 47 ]. The analytical merit figures were a sensitivity of 1380 μA mM −1 cm −2 , linear range from 0.04 to 5.76 mM, LoD of 7.3 μM, but the major drawback displayed by the electrode modified with CuxO-NiO nanocomposite was the loss of performance after exposure to high concentrations of glucose.…”

“…It is worth noting that a Cu x O-NiO nanocomposite and Co(OH) 2 NPs on three-dimensional graphene frameworks have been already described in Section 2 , as they were employed as sensors for the detection of glucose blood in addition to urine [ 47 ].…”

Recent Developments and Future Perspective on Electrochemical Glucose Sensors Based on 2D Materials

“…The research also highlights the impact of decreasing anion electronegativity on improving electrocatalytic efficiency by lowering the voltage required for glucose oxidation and increasing the electrode’s selectivity for glucose molecules. A Cu x O–NiO nanocomposite film was made using a unique modifying approach for non-enzymatic glucose determination [ 64 ]. For 15 min, an anodized Cu electrode was immersed in a solution of H 2 SO 4 , NiSO 4 , and CuSO 4 .…”