Copper(II) Complex Compounds with Mixed Hydrazone Ligands

Abstract

Three Cu(II) complex compounds with mixed hydrazone ligands have been prepared and characterized in view of their potential biological activity. The complex compounds have the formulas: [Cu(HLa)(Lc)Br], [CuLaLc] and [CuLbLc] . Na, where HLa = 4-dimethylamino benzaldehyde-2-benzothiazolyl hydrazone, H2Lb = 2-hydroxybenzaldehyde-2-benzothiazolyl hydrazone and HLc = 2-hydroxy-1-naphthyliden-N,N-dimethyl hydrazone. The complexes have been characterized by elemental and thermogravimetrical analysis, infrared, electronic and EPR spectra. EPR spectral studies of the complexes gave axial symmetry, with the ground state. The bonding parameters calculated from the electronic and EPR spectra indicate strong in-plane p-bonding for all the complexes. Investigations on antibacterial and antifungal activities show that the complexes are more active than the free ligands against various Gram positive, Gram negative bacteria and fungi.

Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity

“…The purpose was to determine the form of coordination of these ligands and their influence on biological activity. The authors reported different copper complexes with bidentate and tridentate ligands as in Btz-16, Btz-22-Btz-24 [138], Btz-17a, Btz-17b, Btz-20 [139], and even using mixed ligands as in Btz-18, Btz-19, Btz-25 [140]. The complexes presented different distorted geometries; for example, Btz- 16 The authors reported different copper complexes with bidentate and tridentate ligands as in Btz-16, Btz-22-Btz-24 [138], Btz-17a, Btz-17b, Btz-20 [139], and even using mixed ligands as in Btz-18, Btz-19, Btz-25 [140].…”

“…The authors reported different copper complexes with bidentate and tridentate ligands as in Btz-16, Btz-22-Btz-24 [138], Btz-17a, Btz-17b, Btz-20 [139], and even using mixed ligands as in Btz-18, Btz-19, Btz-25 [140]. The complexes presented different distorted geometries; for example, Btz- 16 The authors reported different copper complexes with bidentate and tridentate ligands as in Btz-16, Btz-22-Btz-24 [138], Btz-17a, Btz-17b, Btz-20 [139], and even using mixed ligands as in Btz-18, Btz-19, Btz-25 [140]. The complexes presented different distorted geometries; for example, Btz The authors mention that it is possibly due to the more rapid diffusion of these metal complexes through the cell membrane.…”