Copper (II) Acylhydrazinates. Their Synthesis and Characterization

Chohan, Zahid H.; Farooq, Mehrin; Supuran, Claudiu T.

doi:10.1155/mbd.2001.171

Cited by 12 publications

(8 citation statements)

References 12 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[17,18] Similar a-ketoimine chelates with late transition metal centers have been reported for ruthenium, cobalt, nickel, copper and zinc. [43][44][45] The remaining minor product, 4 minor is a regioisomer of 4 major , which yields hydride resonances at d À24.0 and d À27.4, of which the former is trans to BnNH 2 as indicated by the 17.5 Hz coupling to a 15 N signal at d À2. 47.…”

Section: Iridium A-carboxyimine Complexes Hyperpolarized With Para-hymentioning

confidence: 99%

Iridium α‐Carboxyimine Complexes Hyperpolarized with para‐Hydrogen Exist in Nuclear Singlet States before Conversion into Iridium Carbonates

et al. 2018

View full text Add to dashboard Cite

The formation and hyperpolarization of an [Ir(H) (amine)(IMes)(η -imine)]Cl complex that can be created in a hyperpolarized nuclear singlet state is reported. These complexes are formed when an equilibrium mixture of pyruvate, amine (benzylamine or phenylethylamine), and the corresponding imine condensation product, react with preformed [Ir(H) (amine) (IMes)]Cl. These iridium α-carboxyimine complexes exist as two regioisomers differentiated by the position of amine. When examined with para-hydrogen the hydride resonances of the isomer with amine trans to hydride become strongly hyperpolarized. The initial hydride singlet states readily transfer to the corresponding C state in the labelled imine and exhibit magnetic state lifetimes of up to 11 seconds. Their C signals have been detected with up to 420 fold signal gains at 9.4 T. On a longer timescale, and in the absence of H , further reaction leads to the formation of neutral carbonate containing [Ir(amine)(η -CO )(IMes)(η -imine)]. Complexes are characterized by, IR, MS, NMR and X-ray diffraction.

show abstract

Section: Iridium A-carboxyimine Complexes Hyperpolarized With Para-hymentioning

confidence: 99%

Iridium α‐Carboxyimine Complexes Hyperpolarized with para‐Hydrogen Exist in Nuclear Singlet States before Conversion into Iridium Carbonates

et al. 2018

View full text Add to dashboard Cite

show abstract

“…If copper is capsulated in a dimeric complex as for XIII (Figure 3b) or polynuclear as for XVI, the cell growth inhibition dramatically change and became minimal. In the series of complexes [Cu(HL 5 )Y] (XXI-XXIV) having the same metal (copper) and tridentate ONS ligand H 2 L 5 , the second inner sphere ligand Y (Figure 4), influence the biological activity in Figure 4. Representation of complexes XXI-XXIV.…”

Section: Antileukemia Activitymentioning

confidence: 99%

In vitro antileukemia, antibacterial and antifungal activities of some 3d metal complexes: Chemical synthesis and structure – activity relationships

Gulea

Poirier

Roy

et al. 2008

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

The present paper describes the synthesis, characterization and in vitro biological evaluation screening of different classes (ammoniacates, dioximates, carboxylates, semi-and thiosemicarbazidates) of Co(II), Co(III), Cu(II), Ni(II), Mn(II), Zn(II) and Fe(III) complexes. Schiff bases were obtained from the reaction of some salicyl aldehydes with, respectively, furoylhydrazine, benzoylhydrazine, semicarbazide, thiosemicarbazide and S-methylthiosemicarbazide to give tridentate ligands containing ONO, ONS or ONN as donor atoms. The synthetic metal complexes are of various geometrical and electronic structures, thermodynamic and thermal stabilities, and magnetic and conductance properties. All complexes, except those of Cu, are octahedral. Some Cu, Co and Mn compounds have a dimeric or a polymeric structure. The composition and structure of complexes were analysed by elemental analysis, IR and 1 H NMR and 13 C NMR spectroscopies, and magnetochemical, thermoanalytical and molar conductance measurements. All ligands and metal complexes were tested as inhibitors of human leukemia (HL-60) cells growth, and the most potent, the Cu(II) complexes, have been also tested for their in vitro antibacterial and antifungal activities. Structure-activity relationships were carried out.

show abstract

“…X NO3, C2042, CH3CO2" or SO42, n or 2 M Co(II) or Ni(II) Fig. 2" Proposed Structure of the Metal(II) Complexes (1)(2)(3)(4)(5)(6)(7)(8).…”

Section: Results and Discussion Physical Propertiesmentioning

confidence: 99%

Biologically Active Co(II) and Ni(II) Complexes ofN‐(2‐Thienylmethylene)‐2‐Aminothiadiazole

Chohan

2002

Metal-Based Drugs

Self Cite

View full text Add to dashboard Cite

Co(II) and Ni(II) complexes Schiff base, N-(2-thienylmethylene)-2-aminothiadiazole have been prepared and characterized by their physical, spectral and analytical data. The title Schiff-base acts as NNS donor tridentate during the complexation reaction with these metal ions having a composition, [M(L)2]Xn where M=Co(II) or Ni(II), L=, X=NO3−, SO42−, C2O42− or CH3CO2− and n=1 or 2 and show an octahedral geometry. In order to evaluate the effect anions upon chelation, the Schiff-base and its new complexes have been screened for their antibacterial activity against bacterial strains e.g., Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.

show abstract

Copper (II) Acylhydrazinates. Their Synthesis and Characterization

Abstract: ABSTRACT

Cited by 12 publications

References 12 publications

Iridium α‐Carboxyimine Complexes Hyperpolarized with para‐Hydrogen Exist in Nuclear Singlet States before Conversion into Iridium Carbonates

Iridium α‐Carboxyimine Complexes Hyperpolarized with para‐Hydrogen Exist in Nuclear Singlet States before Conversion into Iridium Carbonates

In vitro antileukemia, antibacterial and antifungal activities of some 3d metal complexes: Chemical synthesis and structure – activity relationships

Biologically Active Co(II) and Ni(II) Complexes ofN‐(2‐Thienylmethylene)‐2‐Aminothiadiazole

Contact Info

Product

Resources

About